Imperial College London
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Dr Tolga Bozkurt

Faculty of Natural Sciences, Department of Life Sciences

Reader in Molecular Plant-Microbe
 
 
 
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Contact

 

+44 (0)20 7594 5381o.bozkurt

 
 
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Location

 

6167Sir Alexander Fleming BuildingSouth Kensington Campus

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Summary

 

Publications

Citation

BibTex format

@article{Dagdas:2016:10.7554/eLife.10856,
author = {Dagdas, YF and Belhaj, K and Maqbool, A and Chaparro-Garcia, A and Pandey, P and Petre, B and Tabassum, N and Cruz-Mireles, N and Hughes, RK and Sklenar, J and Win, J and Menke, F and Findlay, K and Banfield, MJ and Kamoun, S and Bozkurt, TO},
doi = {10.7554/eLife.10856},
journal = {eLife},
title = {An effector of the Irish potato famine pathogen antagonizes a host autophagy cargo receptor},
url = {http://dx.doi.org/10.7554/eLife.10856},
volume = {5},
year = {2016}
}
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RIS format (EndNote, RefMan)

TY  - JOUR
AB  - Plants use autophagy to safeguard against infectious diseases. However, how plant pathogens interfere with autophagy-related processes is unknown. Here, we show that PexRD54, an effector from the Irish potato famine pathogen Phytophthora infestans, binds host autophagy protein ATG8CL to stimulate autophagosome formation. PexRD54 depletes the autophagy cargo receptor Joka2 out of ATG8CL complexes and interferes with Joka2's positive effect on pathogen defense. Thus, a plant pathogen effector has evolved to antagonize a host autophagy cargo receptor to counteract host defenses.
AU  - Dagdas,YF
AU  - Belhaj,K
AU  - Maqbool,A
AU  - Chaparro-Garcia,A
AU  - Pandey,P
AU  - Petre,B
AU  - Tabassum,N
AU  - Cruz-Mireles,N
AU  - Hughes,RK
AU  - Sklenar,J
AU  - Win,J
AU  - Menke,F
AU  - Findlay,K
AU  - Banfield,MJ
AU  - Kamoun,S
AU  - Bozkurt,TO
DO  - 10.7554/eLife.10856
PY  - 2016///
SN  - 2050-084X
TI  - An effector of the Irish potato famine pathogen antagonizes a host autophagy cargo receptor
T2  - eLife
UR  - http://dx.doi.org/10.7554/eLife.10856
UR  - http://hdl.handle.net/10044/1/32432
VL  - 5
ER  -
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