Imperial College London
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Dr Tolga Bozkurt

Faculty of Natural Sciences, Department of Life Sciences

Reader in Molecular Plant-Microbe
 
 
 
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Contact

 

+44 (0)20 7594 5381o.bozkurt

 
 
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Location

 

6167Sir Alexander Fleming BuildingSouth Kensington Campus

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Summary

 

Publications

Citation

BibTex format

@article{Wu:2017:10.1073/pnas.1702041114,
author = {Wu, C-H and Abd-El-Haliem, A and Bozkurt, TO and Belhaj, K and Terauchi, R and Vossen, JH and Kamoun, S},
doi = {10.1073/pnas.1702041114},
journal = {Proceedings of the National Academy of Sciences of the United States of America},
pages = {8113--8118},
title = {NLR network mediates immunity to diverse plant pathogens},
url = {http://dx.doi.org/10.1073/pnas.1702041114},
volume = {114},
year = {2017}
}
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RIS format (EndNote, RefMan)

TY  - JOUR
AB  - Both plants and animals rely on nucleotide-binding domain and leucine-rich repeat-containing (NLR) proteins to respond to invading pathogens and activate immune responses. An emerging concept of NLR function is that “sensor” NLR proteins are paired with “helper” NLRs to mediate immune signaling. However, our fundamental knowledge of sensor/helper NLRs in plants remains limited. In this study, we discovered a complex NLR immune network in which helper NLRs in the NRC (NLR required for cell death) family are functionally redundant but display distinct specificities toward different sensor NLRs that confer immunity to oomycetes, bacteria, viruses, nematodes, and insects. The helper NLR NRC4 is required for the function of several sensor NLRs, including Rpi-blb2, Mi-1.2, and R1, whereas NRC2 and NRC3 are required for the function of the sensor NLR Prf. Interestingly, NRC2, NRC3, and NRC4 redundantly contribute to the immunity mediated by other sensor NLRs, including Rx, Bs2, R8, and Sw5. NRC family and NRC-dependent NLRs are phylogenetically related and cluster into a well-supported superclade. Using extensive phylogenetic analysis, we discovered that the NRC superclade probably emerged over 100 Mya from an NLR pair that diversified to constitute up to one-half of the NLRs of asterids. These findings reveal a complex genetic network of NLRs and point to a link between evolutionary history and the mechanism of immune signaling. We propose that this NLR network increases the robustness of immune signaling to counteract rapidly evolving plant pathogens.
AU  - Wu,C-H
AU  - Abd-El-Haliem,A
AU  - Bozkurt,TO
AU  - Belhaj,K
AU  - Terauchi,R
AU  - Vossen,JH
AU  - Kamoun,S
DO  - 10.1073/pnas.1702041114
EP  - 8118
PY  - 2017///
SN  - 0027-8424
SP  - 8113
TI  - NLR network mediates immunity to diverse plant pathogens
T2  - Proceedings of the National Academy of Sciences of the United States of America
UR  - http://dx.doi.org/10.1073/pnas.1702041114
UR  - http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcApp=PARTNER_APP&SrcAuth=LinksAMR&KeyUT=WOS:000406189900090&DestLinkType=FullRecord&DestApp=ALL_WOS&UsrCustomerID=1ba7043ffcc86c417c072aa74d649202
UR  - https://www.pnas.org/content/114/30/8113/
UR  - http://hdl.handle.net/10044/1/51618
VL  - 114
ER  -
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