Imperial College London

DrOndrejCerny

Faculty of MedicineDepartment of Infectious Disease

Research Associate
 
 
 
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Contact

 

o.cerny

 
 
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Location

 

Flowers buildingSouth Kensington Campus

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Summary

 

Suppresion of adaptive immunity by the Salmonella effector SteD

Efficient immune response towards intracellular bacterial pathogens (eg. Salmonella) depends on proper mode of activation of CD4 T lymphocytes. This is mediated by antigen presenting cells such as dendritic cells (DCs). DCs trigger CD4 T lymphocyte-dependent specific immune response by presenting foreign antigens on major histocompatibility complex class II (MHCII). Salmonella evolved a mechanism to specifically block antigen presentation by MHCII thus inhibiting onset of appropriate immune response.

The aim of this project is to reach a deep characterization of the functions of the Salmonella effector SteD on host MHCII-dependent specific immunity in an attempt to prepare a new tool for wider use in clinical practice. To reach this main goal, the work is divided into the following objectives: i) characterization of the effects of SteD on T cell activation in context of host organism; ii) obtaining a detailed understanding of SteD activity on molecular level; iii) identification of proteins targeted by SteD to modulate functions of T lymphocytes; iv) development of SteD as a tool usable for controlled modulation of adaptive immunity.