Publications
172 results found
Mulet X, Templer RH, Woscholski R, et al., 2008, Evidence that phosphatidylinositol promotes curved membrane interfaces, LANGMUIR, Vol: 24, Pages: 8443-8447, ISSN: 0743-7463
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- Citations: 31
Mulet X, Rosivatz E, Ho KK, et al., 2008, Spatial localisation of PIP2 in phase separated giant unilamellar vesicles with a fluorescent PLC-delta 1 PH domain, Lipid Signaling Protocols, Editors: Larijani, Woscholski, Rosser, Publisher: Humana Press, ISBN: 978-1588297273
Seddon AM, Lorch M, Ces O, et al., 2008, Phosphatidylglycerol lipids enhance folding of an α helical membrane protein, JOURNAL OF MOLECULAR BIOLOGY, Vol: 380, Pages: 548-556, ISSN: 0022-2836
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- Citations: 40
Corsi J, Dymond MK, Ces O, et al., 2008, DNA that is dispersed in the liquid crystalline phases of phospholipids is actively transcribed, Chemical Communications
Alley SH, Ces O, Barahona M, et al., 2008, X-ray diffraction measurement of the monolayer spontaneous curvature of dioleoylphosphatidylglycerol, CHEMISTRY AND PHYSICS OF LIPIDS, Vol: 154, Pages: {64-67}-{64-67}, ISSN: 0009-3084
Phosphatidylglycerol (PG) is an anionic lipid commonly found in large proportions in the cell membranes of bacteria and plants and, to a lesser extent, in animal cells. PG plays an important role in the regulation and determination of the elastic properties of the membrane. Using small angle X-ray scattering experiments, we obtain that the monolayer spontaneous curvature of dioleoylphosphatidylglycerol (DOPG) is -1/150 +/- 0.021 nm(-1) when measured in 150mM NaCl. When the experiments are carried out in 150 mM NaCl and 20 mM MgCl2, the value obtained for the monolayer spontaneous curvature is -1/8.7 +/- 0.037 nm(-1). These values are of importance in modelling the effects of curvature elastic stress in membrane lipid homeostasis in the bacterium Acholeplasma laidlawii [Alley, S.H., Barahona, M., Ces, O., Templer, R.H., in press. Biophysical regulation of lipid biosynthesis in the plasma membrane. Biophys. J.] and indicate that divalent cations can play a significant role in altering curvature elastic stress. (C) 2008 Elsevier Ireland Ltd. All rights reserved.
Conn CE, Ces O, Squires AM, et al., 2008, A pressure-jump time-resolved x-ray diffraction study of cubic-cubic transition kinetics in monoolein, LANGMUIR, Vol: 24, Pages: 2331-2340, ISSN: 0743-7463
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- Citations: 49
Alley SH, Ces O, Templer RH, et al., 2008, Biophysical regulation of lipid biosynthesis in the plasma membrane, BIOPHYSICAL JOURNAL, Vol: 94, Pages: {2938-2954}-{2938-2954}, ISSN: 0006-3495
We present a cellular model of lipid biosynthesis in the plasma membrane that couples biochemical and biophysical features of the enzymatic network of the cell-wall-less Mycoplasma Acholeplasma laidlawii. In particular, we formulate how the stored elastic energy of the lipid bilayer can modify the activity of curvature-sensitive enzymes through the binding of amphipathic a-helices. As the binding depends on lipid composition, this results in a biophysical feedback mechanism for the regulation of the stored elastic energy. The model shows that the presence of feedback increases the robustness of the steady state of the system, in the sense that biologically inviable nonbilayer states are less likely. We also show that the biophysical and biochemical features of the network have implications as to which enzymes are most efficient at implementing the regulation. The network imposes restrictions on the steady-state balance between bilayer and nonbilayer lipids and on the concentrations of particular lipids. Finally, we consider the influence of the length of the amphipathic a-helix on the efficacy of the feedback and propose experimental measurements and extensions of the modeling framework.
Casey DR, Sebai SC, Shearman GC, et al., 2008, Formulation affects the rate of membrane degradation catalyzed by cationic amphiphilic drugs, Industrial & Engineering Chemistry Research, Vol: 47, Pages: 650-655
Shearman GC, Khoo BJ, Motherwell M-L, et al., 2007, Calculations of and evidence for chain packing stress in inverse lyotropic bicontinuous cubic phases, LANGMUIR, Vol: 23, Pages: 7276-7285, ISSN: 0743-7463
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- Citations: 60
Shearman GC, Attard GS, Hunt AN, et al., 2007, Using membrane stress to our advantage, BIOCHEMICAL SOCIETY TRANSACTIONS, Vol: 35, Pages: 498-501, ISSN: 0300-5127
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- Citations: 17
Shearman GC, Sebai SC, Mulet X, et al., 2007, A novel mechanism for drug transport through membranes, 51st Annual Meeting of the Biophysical-Society, Publisher: BIOPHYSICAL SOCIETY, Pages: 239A-240A, ISSN: 0006-3495
Baciu M, Sebai S C, Ces O, et al., 2006, Degradative Transport of Cationic Amphiphilic Drugs Across Phospholipid Bilayers, Phil. Trans . R. Soc., Vol: 364, Pages: 2597-2614
Ces O, Mulet X, 2006, Physical coupling between lipids and proteins: a paradigm for cellular control, Signal Transduction, Vol: 6, Pages: 112-132
The long held view of biological lipids acting as passive building blocks in biological membranes has now been superseded by the notion that the structure and composition of the membrane plays a crucial role in the regulation of protein function and numerous other biological processes. This may be the result of specific protein-lipid recognition phenomena or alternatively regulation by sensing properties of the membrane such as the stored curvature elastic stress with the latter being the focus of the review.
Conn C, Ces O, Mulet X, et al., 2006, Dynamics of structural transformations between lamellar and inverse bicontinuous cubic lyotropic phases, Physical Review Letters, Pages: 108102-1-108102-4
Shearman G C, Ces O, Templer R H, et al., 2006, Inverse Lyotropic Phases of Lipids and Membrane Curvature, J. Phys.: Condens. Matter, Vol: 18, Pages: S1105-S1124
Seddon J M, Squires A M, Conn C E, et al., 2006, Pressure-jump X-ray Studies of Liquid Crystal Transitions in Lipids, Phil. Trans. R. Soc. A, Vol: 364, Pages: 2635-2655
Sebai S, Baciu M, Ces O, et al., 2006, To lipophilicity and beyond - towards a deeper understanding of radioligand non-specific binding, 6th International Symposium on Neuroreceptor Mapping, Publisher: ACADEMIC PRESS INC ELSEVIER SCIENCE, Pages: T56-T56, ISSN: 1053-8119
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- Citations: 6
Seddon JM, Squires A, Ces O, et al., 2003, Time-resolved diffraction studies of inverse cubic phases and phase transitions of lipids, Amsterdam, Meeting on self-assembly - the future, Massa Marittima, Italy, 2002, Publisher: I O S Press, Pages: 212-221
Seddon JM, Ces O, Templer RH, et al., 2003, Structure and phase behaviour of synthetic glycolipids, 2nd Anglo-Japanese Seminar on Liquid Crystals, Publisher: TAYLOR & FRANCIS LTD, Pages: 313-320, ISSN: 1542-1406
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- Citations: 7
Ces O, Seddon JM, Templer RH, et al., 2002, Differential scanning calorimetry and x-ray diffraction studies of glycolipid membranes, Cambridge, 1st annual international conference on biophysical chemistry, Imperial College of Science & Technology London, London, England, 19 - 21 September 2001, Publisher: Royal Society of Chemistry, Pages: 267-276
Squires A, Templer RH, Ces O, et al., 2000, Kinetics of lyotropic phase transitions involving the inverse bicontinous cubic phases, Langmuir, Vol: 16, Pages: 3578-3582, ISSN: 0743-7463
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