Imperial College London
Alternate

Professor Oscar Ces

Faculty of Natural Sciences, Department of Chemistry

Head of Department, August von Hofmann Chair of Chemistry
 
 
 
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Contact

 

+44 (0)20 7594 3754o.ces Website

 
 
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Location

 

G04AMolecular Sciences Research HubWhite City Campus

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Summary

 

Publications

Citation

BibTex format

@article{Trantidou:2018:10.1039/c8lc00028j,
author = {Trantidou, T and Friddin, M and Salehi-Reyhani, S and Ces, O and Elani, Y},
doi = {10.1039/c8lc00028j},
journal = {Lab on a Chip},
pages = {2488--2509},
title = {Droplet microfluidics for the construction of compartmentalised model membranes},
url = {http://dx.doi.org/10.1039/c8lc00028j},
volume = {18},
year = {2018}
}
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RIS format (EndNote, RefMan)

TY  - JOUR
AB  - The design of membrane-based constructs with multiple compartments is of increasing importance given their potential applications as microreactors, as artificial cells in synthetic-biology, as simplified cell models, and as drug delivery vehicles. The emergence of droplet microfluidics as a tool for their construction has allowed rapid scale-up in generation throughput, scale-down of size, and control over gross membrane architecture. This is true on several levels: size, level of compartmentalisation and connectivity of compartments can all be programmed to various degrees. This tutorial review explains and explores the reasons behind this. We discuss microfluidic strategies for the generation of a family of compartmentalised systems that have lipid membranes as the basic structural motifs, where droplets are either the fundamental building blocks, or are precursors to the membrane-bound compartments. We examine the key properties associated with these systems (including stability, yield, encapsulation efficiency), discuss relevant device fabrication technologies, and outline the technical challenges. In doing so, we critically review the state-of-play in this rapidly advancing field.
AU  - Trantidou,T
AU  - Friddin,M
AU  - Salehi-Reyhani,S
AU  - Ces,O
AU  - Elani,Y
DO  - 10.1039/c8lc00028j
EP  - 2509
PY  - 2018///
SN  - 1473-0189
SP  - 2488
TI  - Droplet microfluidics for the construction of compartmentalised model membranes
T2  - Lab on a Chip
UR  - http://dx.doi.org/10.1039/c8lc00028j
UR  - http://hdl.handle.net/10044/1/61680
VL  - 18
ER  -
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