Imperial College London
Alternate

Professor Oscar Ces

Faculty of Natural Sciences, Department of Chemistry

Head of Department, August von Hofmann Chair of Chemistry
 
 
 
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Contact

 

+44 (0)20 7594 3754o.ces Website

 
 
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Location

 

G04AMolecular Sciences Research HubWhite City Campus

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Summary

 

Publications

Citation

BibTex format

@article{Friddin:2019:10.1038/s42004-018-0101-4,
author = {Friddin, M and Bolognesi, G and Salehi-Reyhani, A and Ces, O and Elani, Y},
doi = {10.1038/s42004-018-0101-4},
journal = {Communications Chemistry},
pages = {1--7},
title = {Direct manipulation of liquid ordered lipid membrane domains using optical traps},
url = {http://dx.doi.org/10.1038/s42004-018-0101-4},
volume = {2},
year = {2019}
}
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RIS format (EndNote, RefMan)

TY  - JOUR
AB  - Multicomponent lipid bilayers can give rise to coexisting liquid domains that are thought to influence a host of cellular activities. There currently exists no method to directly manipulate such domains, hampering our understanding of their significance. Here we report a system that allows individual liquid ordered domains that exist in a liquid disordered matrix to be directly manipulated using optical tweezers. This allows us to drag domains across the membrane surface of giant vesicles that are adhered to a glass surface, enabling domain location to be defined with spatiotemporal control. We can also use the laser to select individual vesicles in a population to undergo mixing/demixing by locally heating the membrane through the miscibility transition, demonstrating a further layer of control. This technology has potential as a tool to shed light on domain biophysics, on their role in biology, and in sculpting membrane assemblies with user-defined membrane patterning.
AU  - Friddin,M
AU  - Bolognesi,G
AU  - Salehi-Reyhani,A
AU  - Ces,O
AU  - Elani,Y
DO  - 10.1038/s42004-018-0101-4
EP  - 7
PY  - 2019///
SN  - 2399-3669
SP  - 1
TI  - Direct manipulation of liquid ordered lipid membrane domains using optical traps
T2  - Communications Chemistry
UR  - http://dx.doi.org/10.1038/s42004-018-0101-4
UR  - https://www.nature.com/articles/s42004-018-0101-4
VL  - 2
ER  -
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