Imperial College London

Dr Özgen Deniz

Faculty of MedicineDepartment of Immunology and Inflammation

Imperial College Research Fellow
 
 
 
//

Contact

 

o.deniz Website

 
 
//

Location

 

Commonwealth BuildingHammersmith Campus

//

Summary

 

Summary

Dr. Özgen Deniz received her PhD in 2014 from the University of Barcelona under the supervision of Professor Modesto Orozco. During her PhD, Özgen's research focused on chromatin dynamics during the cell cycle in budding yeast. She then joined Dr Miguel Branco’s group at Queen Mary University of London to investigate the epigenetic regulation of transposons in early development and cancer. During this time, she was awarded a WHRI-ACADEMY COFUND International Fellowship, by the Marie Curie Actions, H2020, European Commission and secured funding from Barts Charity.

In 2021, Özgen joined the Centre for Haematology as an Imperial College Research Fellow to establish her own research programme. Her research focuses on the contribution of non-coding DNA sequences, particularly transposons, to oncogenic networks in acute myeloid leukaemia (AML). Using an integrative approach, combining functional and computational genomics, the Deniz lab studies the activation of transposons as oncogenic regulators and their contribution to disease development and drug resistance in AML.

Selected Publications

Journal Articles

Deniz Ö, Ahmed M, Todd CD, et al., 2020, Endogenous retroviruses are a source of enhancers with oncogenic potential in acute myeloid leukaemia, Nature Communications, Vol:11, ISSN:2041-1723, Pages:1-14

Todd CD, Deniz Ö, Taylor D, et al., 2019, Functional evaluation of transposable elements as enhancers in mouse embryonic and trophoblast stem cells, Elife, Vol:8, ISSN:2050-084X, Pages:1-20

Deniz Ö, Frost JM, Branco MR, 2019, Regulation of transposable elements by DNA modifications, Nature Reviews Genetics, Vol:20, ISSN:1471-0056, Pages:417-431

Deniz Ö, de la Rica L, Cheng KCL, et al., 2018, SETDB1 prevents TET2-dependent activation of IAP retroelements in naïve embryonic stem cells, Genome Biology, Vol:19, ISSN:1474-7596, Pages:1-11

Flores O, Deniz Ö, Soler-López M, et al., 2014, Fuzziness and noise in nucleosomal architecture, Nucleic Acids Research, Vol:42, ISSN:0305-1048, Pages:4934-4946

More Publications