Publications
101 results found
Brigic A, Symons NRA, Faiz O, et al., 2013, A systematic review regarding the feasibility and safety of endoscopic full thickness resection (EFTR) for colonic lesions, SURGICAL ENDOSCOPY AND OTHER INTERVENTIONAL TECHNIQUES, Vol: 27, Pages: 3520-3529, ISSN: 0930-2794
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- Citations: 19
Mamidanna R, Almoudaris AM, Bottle A, et al., 2013, National outcomes and uptake of laparoscopic gastrectomy for cancer in England, SURGICAL ENDOSCOPY AND OTHER INTERVENTIONAL TECHNIQUES, Vol: 27, Pages: 3348-3358, ISSN: 0930-2794
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- Citations: 16
Bagnall NM, Faiz O, 2013, Reply to: Surgical treatment of colon cancer in patients aged 80 years and older, CANCER, Vol: 119, Pages: 3419-3419, ISSN: 0008-543X
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- Citations: 1
Bagnall NM, Faiz O, 2013, Laparoscopic Colectomy: The View from the United Kingdom, JOURNAL OF GASTROINTESTINAL SURGERY, Vol: 17, Pages: 1544-1544, ISSN: 1091-255X
Bagnall NM, Faiz O, Darzi A, et al., 2013, What is the utility of preoperative frailty assessment for risk stratification in cardiac surgery?, INTERACTIVE CARDIOVASCULAR AND THORACIC SURGERY, Vol: 17, Pages: 398-402, ISSN: 1569-9293
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- Citations: 56
Nachiappan S, Markar S, Karthikesaligam A, et al., 2013, Prophylactic Mesh Placement in High-Risk Patients Undergoing Elective Laparotomy: A Systematic Review, WORLD JOURNAL OF SURGERY, Vol: 37, Pages: 1861-1871, ISSN: 0364-2313
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- Citations: 40
Mamidanna R, Faiz O, 2013, Letter Re: "Operative Outcomes Beyond 30-Day Mortality: Colorectal Cancer Surgery in Oldest Old" No Reply, ANNALS OF SURGERY, Vol: 258, Pages: E13-E13, ISSN: 0003-4932
Nachiappan S, Markar S, Karthikesalingam A, et al., 2013, Erratum to: Prophylactic Mesh Placement in High-Risk Patients Undergoing Elective Laparotomy: A Systematic Review., World J Surg
Pinto A, Faiz O, Vincent C, 2013, Managing the after effects of serious patient safety incidents in the NHS: an online survey study, POSTGRADUATE MEDICAL JOURNAL, Vol: 89, Pages: 266-273, ISSN: 0032-5473
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- Citations: 3
Ashraf SQ, Burns EM, Jani A, et al., 2013, The economic impact of anastomotic leakage after anterior resections in English NHS hospitals: are we adequately remunerating them?, COLORECTAL DISEASE, Vol: 15, Pages: E190-E198, ISSN: 1462-8910
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- Citations: 82
Almoudaris AM, Mamidanna R, Bottle A, et al., 2013, Failure to Rescue Patients After Reintervention in Gastroesophageal Cancer Surgery in England, JAMA SURGERY, Vol: 148, Pages: 272-276, ISSN: 2168-6254
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- Citations: 37
Atkin W, Dadswell E, Wooldrage K, et al., 2013, Computed tomographic colonography versus colonoscopy for investigation of patients with symptoms suggestive of colorectal cancer (SIGGAR): a multicentre randomised trial., Lancet
BACKGROUND: Colonoscopy is the gold-standard test for investigation of symptoms suggestive of colorectal cancer; computed tomographic colonography (CTC) is an alternative, less invasive test. However, additional investigation after CTC is needed to confirm suspected colonic lesions, and this is an important factor in establishing the feasibility of CTC as an alternative to colonoscopy. We aimed to compare rates of additional colonic investigation after CTC or colonoscopy for detection of colorectal cancer or large (≥10 mm) polyps in symptomatic patients in clinical practice.METHODS: This pragmatic multicentre randomised trial recruited patients with symptoms suggestive of colorectal cancer from 21 UK hospitals. Eligible patients were aged 55 years or older and regarded by their referring clinician as suitable for colonoscopy. Patients were randomly assigned (2:1) to colonoscopy or CTC by computer-generated random numbers, in blocks of six, stratified by trial centre and sex. We analysed the primary outcome-the rate of additional colonic investigation-by intention to treat. The trial is an International Standard Randomised Controlled Trial, number 95152621.FINDINGS: 1610 patients were randomly assigned to receive either colonoscopy (n=1072) or CTC (n=538). 30 patients withdrew consent, leaving for analysis 1047 assigned to colonoscopy and 533 assigned to CTC. 160 (30·0%) patients in the CTC group had additional colonic investigation compared with 86 (8·2%) in the colonoscopy group (relative risk 3·65, 95% CI 2·87-4·65; p<0·0001). Almost half the referrals after CTC were for small (<10 mm) polyps or clinical uncertainty, with low predictive value for large polyps or cancer. Detection rates of colorectal cancer or large polyps in the trial cohort were 11% for both procedures. CTC missed 1 of 29 colorectal cancers and colonoscopy missed none (of 55). Serious adverse events were rare.INTERPRETATION: Guidelines are needed
Halligan S, Wooldrage K, Dadswell E, et al., 2013, Computed tomographic colonography versus barium enema for diagnosis of colorectal cancer or large polyps in symptomatic patients (SIGGAR): a multicentre randomised trial., Lancet, Vol: 381, Pages: 1185-1193
BACKGROUND: Barium enema (BE) is widely available for diagnosis of colorectal cancer despite concerns about its accuracy and acceptability. Computed tomographic colonography (CTC) might be a more sensitive and acceptable alternative. We aimed to compare CTC and BE for diagnosis of colorectal cancer or large polyps in symptomatic patients in clinical practice.METHODS: This pragmatic multicentre randomised trial recruited patients with symptoms suggestive of colorectal cancer from 21 UK hospitals. Eligible patients were aged 55 years or older and regarded by their referring clinician as suitable for radiological investigation of the colon. Patients were randomly assigned (2:1) to BE or CTC by computer-generated random numbers, in blocks of six, stratified by trial centre and sex. We analysed the primary outcome-diagnosis of colorectal cancer or large (≥10 mm) polyps-by intention to treat. The trial is an International Standard Randomised Controlled Trial, number 95152621.FINDINGS: 3838 patients were randomly assigned to receive either BE (n=2553) or CTC (n=1285). 34 patients withdrew consent, leaving for analysis 2527 assigned to BE and 1277 assigned to CTC. The detection rate of colorectal cancer or large polyps was significantly higher in patients assigned to CTC than in those assigned to BE (93 [7·3%] of 1277 vs 141 [5·6%] of 2527, relative risk 1·31, 95% CI 1·01-1·68; p=0·0390). CTC missed three of 45 colorectal cancers and BE missed 12 of 85. The rate of additional colonic investigation was higher after CTC than after BE (283 [23·5%] of 1206 CTC patients had additional investigation vs 422 [18·3%] of 2300 BE patients; p=0·0003), due mainly to a higher polyp detection rate. Serious adverse events were rare.INTERPRETATION: CTC is a more sensitive test than BE. Our results suggest that CTC should be the preferred radiological test for patients with symptoms suggestive of colorectal cancer.FUNDING: NIH
Grailey K, Markar SR, Karthikesalingam A, et al., 2013, Laparoscopic versus open colorectal resection in the elderly population, SURGICAL ENDOSCOPY AND OTHER INTERVENTIONAL TECHNIQUES, Vol: 27, Pages: 19-30, ISSN: 0930-2794
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- Citations: 66
Howell AM, Jarral OA, Faiz O, et al., 2013, How should perineal wounds be closed following abdominoperineal resection in patients post radiotherapy - Primary closure or flap repair? Best evidence topic (BET), INTERNATIONAL JOURNAL OF SURGERY, Vol: 11, Pages: 514-517, ISSN: 1743-9191
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- Citations: 42
Burns EM, Currie A, Bottle A, et al., 2013, Minimal-access colorectal surgery is associated with fewer adhesion-related admissions than open surgery, Br J Surg, Vol: 100, Pages: 152-159, ISSN: 1365-2168
BACKGROUND: This study aimed to describe national intermediate-term admission rates for incisional hernia or clinically apparent adhesions following colorectal surgery, and to compare rates following laparoscopic and open approaches. METHODS: Patients undergoing primary colorectal resection between 2002 and 2008 were included from the Hospital Episode Statistics database. Subsequent inpatient admissions were extracted for up to 3 years after the initial operation or to the end of the study period. Outcomes examined were admissions with a diagnosis of, or operative interventions for, incisional hernia or adhesions. RESULTS: A total of 187 148 patients were included between 2002 and 2008, with median follow-up of 31.8 (interquartile range 13.1-35.3) months. Some 8885 (4.7 per cent) of these patients were admitted with a diagnosis of, or underwent a repair of, an incisional hernia. In multiple regression analysis, use of laparoscopy was not a predictor of operative intervention for incisional hernia (odds ratio 1.09, 95 per cent confidence interval (c.i.) 0.99 to 1.21; P = 0.083). Some 15 125 (8.1 per cent) of the patients were admitted with a diagnosis of adhesions or had a procedure for division of adhesions. Overall, 3.5 per cent (6637 of 187 148) of patients underwent adhesiolysis. Patients selected for a laparoscopic procedure had lower rates of admission for adhesions (6.3 per cent (692 of 11 013) for laparoscopic versus 8.2 per cent (14 433 of 176 135) for open surgery; P < 0.001) and reintervention for adhesions (2.8 per cent (305 of 11 013) versus 3.6 per cent (6325 of 176 135) respectively; P < 0.001) than those undergoing an open procedure. In multiple regression analysis, patients selected for a laparoscopic procedure had lower subsequent intervention rates for adhesions (odds ratio 0.80, 95 per cent c.i. 0.71 to 0.90; P < 0.001). DISCUSSION: Patients undergoing colorectal resection who are selected for the laparoscopic approach have a lower risk o
Pinto A, Faiz O, Vincent C, 2012, Managing the after effects of serious patient safety incidents in the NHS: an online survey study, BMJ QUALITY & SAFETY, Vol: 21, Pages: 1001-1008, ISSN: 2044-5415
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- Citations: 12
Mamidanna R, Faiz O, 2012, Comment on: Laparoscopic colorectal surgery in elderly patients: a case-control study of 15 years of experience, AMERICAN JOURNAL OF SURGERY, Vol: 204, Pages: 548-549, ISSN: 0002-9610
Bagnall NM, Mamidanna R, Faiz O, 2012, Response to "Long Term Outcomes Following Surgery for Colorectal Cancers in Octogenarians: A Single Institution's Experience of 204 Patients", JOURNAL OF GASTROINTESTINAL SURGERY, Vol: 16, Pages: 2007-2008, ISSN: 1091-255X
Bezemer J, Cope A, Faiz O, et al., 2012, Participation of Surgical Residents in Operations: Challenging a Common Classification, WORLD JOURNAL OF SURGERY, Vol: 36, Pages: 2011-2014, ISSN: 0364-2313
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- Citations: 12
Markar SR, Blackburn S, Cobb R, et al., 2012, Laparoscopic Versus Open Appendectomy for Complicated and Uncomplicated Appendicitis in Children, Journal of Gastrointestinal Surgery, ISSN: 1091-255X
Mamidanna R, Eid-Arimoku L, Almoudaris AM, et al., 2012, Poor 1-Year Survival in Elderly Patients Undergoing Nonelective Colorectal Resection, DISEASES OF THE COLON & RECTUM, Vol: 55, Pages: 788-796, ISSN: 0012-3706
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- Citations: 34
Burns EM, Faiz OD, 2012, Letter Re: "Hospital Variation in 30-Day Mortality After Colorectal Cancer Surgery in Denmark: The Contribution of Hospital Volume and Patient Characteristics.", ANNALS OF SURGERY, Vol: 255, Pages: E19-E19, ISSN: 0003-4932
Burns EM, Faiz OD, 2012, Re: How often do patients return to the operating room after colorectal surgery?, COLORECTAL DISEASE, Vol: 14, Pages: 642-642, ISSN: 1462-8910
Almoudaris AM, Burns E, Bottle A, et al., 2012, Single measures of performance do not reflect overall institutional quality in colorectal cancer surgery, Gut
Objective To evaluate overall performance of English colorectal cancer surgical units identified as outliers for a single quality measure—30 day inhospital mortality.Design 144 542 patients that underwent primary major colorectal cancer resection between 2000/2001 and 2007/2008 in 149 English National Health Service units were included from hospital episodes statistics. Casemix adjusted funnel plots were constructed for 30 day inhospital mortality, length of stay, unplanned readmission within 28 days, reoperation, failure to rescue-surgical (FTR-S) and abdominoperineal excision (APE) rates. Institutional performance was evaluated across all other domains for institutions deemed outliers for 30 day mortality. Outliers were those that lay on or breached 3 SD control limits. ‘Acceptable’ performance was defined if units appeared under the upper 2 SD limit.Results 5 high mortality outlier (HMO) units and 15 low mortality outlier (LMO) units were identified. Of the five HMO units, two were substandard performance outliers (ie, above 3 SD) on another metric (both on high reoperation rates). A further two HMO institutions exceeded the second but not the third SD limits for substandard performance on other outcome metrics. One of the 15 LMO units exceeded 3 SD for substandard performance (APE rate). One LMO institution exceeded the second but not the third SD control limits for high reoperation rates. Institutional mortality correlated with FTR-S and reoperations (R=0.445, p<0.001 and R=0.191, p<0.020 respectively).Conclusions Performance appraisal in colorectal surgery is complex and dependent on stakeholder perspective. Benchmarking units solely on a single performance measure is over simplistic and potentially hazardous. A global appraisal of institutional outcome is required to contextualise performance.
Mamidanna R, Bottle A, Aylin P, et al., 2012, Short-Term Outcomes Following Open Versus Minimally Invasive Esophagectomy for Cancer in England <i>A Population</i>-<i>Based National Study</i>, ANNALS OF SURGERY, Vol: 255, Pages: 197-203, ISSN: 0003-4932
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- Citations: 180
Kavanagh D, Haq I, Almoudaris AM, et al., 2012, Dynamic Magnetic Resonance Imaging Demonstrates the Integrity of Perineal Reconstruction Following Cylindrical Abdominoperineal Excision with Reconstruction of the Pelvic Floor Using Porcine Collagen, Case Reports in Medicine
Currie A, Burns E, Darzi A, et al., 2012, Has shortened surgical training lead to poorer rectal cancer surgical outcomes?, International Surgical Congress of the Association-of-Surgeons-of-Great-Britain-and-Ireland (ASGBI), Publisher: WILEY-BLACKWELL, Pages: 107-108, ISSN: 0007-1323
Howell AMR, Cheung IHW, Liu WK, et al., 2012, Comparison of colorectal surgery outcome beyond the conventional 30 day mortality in the elderly and young, International Surgical Congress of the Association-of-Surgeons-of-Great-Britain-and-Ireland (ASGBI), Publisher: WILEY-BLACKWELL, Pages: 70-70, ISSN: 0007-1323
Mamidanna R, Faiz O, 2012, Accuracy of clinical coding from 1210 appendicectomies in a British district general hospital, INTERNATIONAL JOURNAL OF SURGERY, Vol: 10, Pages: 270-271, ISSN: 1743-9191
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