Publications

BibTex format

@article{Warembourg:2019:10.1016/j.jacc.2019.06.069,
author = {Warembourg, C and Maitre, L and Tamayo-Uria, I and Fossati, S and Roumeliotaki, T and Aasvang, GM and Andrusaityte, S and Casas, M and Cequier, E and Chatzi, L and Dedele, A and Gonzalez, JR and Grauleviien, R and Haug, LS and Hernandez-Ferrer, C and Heude, B and Karachaliou, M and Krog, NH and McEachan, R and Nieuwenhuijsen, M and Petraviciene, I and Quentin, J and Robinson, O and Sakhi, AK and Slama, R and Thomsen, C and Urquiza, J and Vafeiadi, M and West, J and Wright, J and Vrijheid, M and Basagaña, X},
doi = {10.1016/j.jacc.2019.06.069},
journal = {Journal of the American College of Cardiology},
pages = {1317--1328},
title = {Early-life environmental exposures and blood pressure in children},
url = {http://dx.doi.org/10.1016/j.jacc.2019.06.069},
volume = {74},
year = {2019}
}

Download

RIS format (EndNote, RefMan)

TY  - JOUR
AB  - Background: Growing evidence exists about the fetal and environmental origins of hypertension, but mainly limited to single-exposure studies. The exposome has been proposed as a more holistic approach by studying many exposures simultaneously. Objectives: This study aims to evaluate the association between a wide range of prenatal and postnatal exposures and blood pressure (BP) in children. Methods: Systolic and diastolic BP were measured among 1,277 children from the European HELIX (Human Early-Life Exposome) cohort aged 6 to 11 years. Prenatal (n = 89) and postnatal (n = 128) exposures include air pollution, built environment, meteorology, natural spaces, traffic, noise, chemicals, and lifestyles. Two methods adjusted for confounders were applied: an exposome-wide association study considering the exposures independently, and the deletion-substitution-addition algorithm considering all the exposures simultaneously. Results: Decreases in systolic BP were observed with facility density (β change for an interquartile-range increase in exposure: −1.7 mm Hg [95% confidence interval (CI): −2.5 to −0.8 mm Hg]), maternal concentrations of polychlorinated biphenyl 118 (−1.4 mm Hg [95% CI: −2.6 to −0.2 mm Hg]) and child concentrations of dichlorodiphenyldichloroethylene (DDE: −1.6 mm Hg [95% CI: −2.4 to −0.7 mm Hg]), hexachlorobenzene (−1.5 mm Hg [95% CI: −2.4 to −0.6 mm Hg]), and mono−benzyl phthalate (−0.7 mm Hg [95% CI: −1.3 to −0.1 mm Hg]), whereas increases in systolic BP were observed with outdoor temperature during pregnancy (1.6 mm Hg [95% CI: 0.2 to 2.9 mm Hg]), high fish intake during pregnancy (2.0 mm Hg [95% CI: 0.4 to 3.5 mm Hg]), maternal cotinine concentrations (1.2 mm Hg [95% CI: -0.3 to 2.8 mm Hg]), and child perfluorooctanoate concentrations (0.9 mm Hg [95% CI: 0.1 to 1.6 mm Hg]). Decreases in diastolic BP were observed with outdoor temperature at examinati
AU  - Warembourg,C
AU  - Maitre,L
AU  - Tamayo-Uria,I
AU  - Fossati,S
AU  - Roumeliotaki,T
AU  - Aasvang,GM
AU  - Andrusaityte,S
AU  - Casas,M
AU  - Cequier,E
AU  - Chatzi,L
AU  - Dedele,A
AU  - Gonzalez,JR
AU  - Grauleviien,R
AU  - Haug,LS
AU  - Hernandez-Ferrer,C
AU  - Heude,B
AU  - Karachaliou,M
AU  - Krog,NH
AU  - McEachan,R
AU  - Nieuwenhuijsen,M
AU  - Petraviciene,I
AU  - Quentin,J
AU  - Robinson,O
AU  - Sakhi,AK
AU  - Slama,R
AU  - Thomsen,C
AU  - Urquiza,J
AU  - Vafeiadi,M
AU  - West,J
AU  - Wright,J
AU  - Vrijheid,M
AU  - Basagaña,X
DO  - 10.1016/j.jacc.2019.06.069
EP  - 1328
PY  - 2019///
SN  - 0735-1097
SP  - 1317
TI  - Early-life environmental exposures and blood pressure in children
T2  - Journal of the American College of Cardiology
UR  - http://dx.doi.org/10.1016/j.jacc.2019.06.069
UR  - https://www.sciencedirect.com/science/article/pii/S0735109719359595?via%3Dihub
UR  - http://hdl.handle.net/10044/1/73109
VL  - 74
ER  -

Download

DrOliverRobinson

Contact

Location

Summary

Citation

BibTex format

RIS format (EndNote, RefMan)