Imperial College London
Alternate

DrOliverRobinson

Faculty of Medicine, School of Public Health

Lecturer in Molecular Epidemiology
 
 
 
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o.robinson

 
 
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Location

 

1103Sir Michael Uren HubWhite City Campus

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Summary

 

Publications

Citation

BibTex format

@article{Vineis:2020:10.1016/j.envint.2020.105887,
author = {Vineis, P and Chadeau, M and Dagnino, S and Mudway, I and Robinson, O and Dehghan, A},
doi = {10.1016/j.envint.2020.105887},
journal = {Environment International},
pages = {1--13},
title = {What's new in the Exposome?},
url = {http://dx.doi.org/10.1016/j.envint.2020.105887},
volume = {143},
year = {2020}
}
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RIS format (EndNote, RefMan)

TY  - JOUR
AB  - The exposome concept refers to the totality of exposures from a variety of external and internal sources including chemical agents, biological agents, or radiation, from conception onward, over a complete lifetime. It encompasses also “psychosocial components” including the impact of social relations and socio-economic position on health. In this review we provide examples of recent contributions from exposome research, where we believe their application will be of the greatest value for moving forward. So far, environmental epidemiology has mainly focused on hard outcomes, such as mortality, disease exacerbation and hospitalizations. However, there are many subtle outcomes that can be related to environmental exposures, and investigations can be facilitated by an improved understanding of internal biomarkers of exposure and response, through the application of omic technologies. Second, though we have a wealth of studies on environmental pollutants, the assessment of causality is often difficult because of confounding, reverse causation and other uncertainties. Biomarkers and omic technologies may allow better causal attribution, for example using instrumental variables in triangulation, as we discuss here. Even more complex is the understanding of how social relationships (in particular socio-economic differences) influence health and imprint on the fundamental biology of the individual. The identification of molecular changes that are intermediate between social determinants and disease status is a way to fill the gap. Another field in which biomarkers and omics are relevant is the study of mixtures. Epidemiology often deals with complex mixtures (e.g. ambient air pollution, food, smoking) without fully disentangling the compositional complexity of the mixture, or with rudimentary approaches to reflect the overall effect of multiple exposures or components.From the point of view of disease mechanisms, most models hypothesize that several stages need t
AU  - Vineis,P
AU  - Chadeau,M
AU  - Dagnino,S
AU  - Mudway,I
AU  - Robinson,O
AU  - Dehghan,A
DO  - 10.1016/j.envint.2020.105887
EP  - 13
PY  - 2020///
SN  - 0160-4120
SP  - 1
TI  - What's new in the Exposome?
T2  - Environment International
UR  - http://dx.doi.org/10.1016/j.envint.2020.105887
UR  - https://www.sciencedirect.com/science/article/pii/S0160412020318420?via%3Dihub
UR  - http://hdl.handle.net/10044/1/80945
VL  - 143
ER  -
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