Imperial College London
Alternate

DrOliverRobinson

Faculty of Medicine, School of Public Health

Lecturer in Molecular Epidemiology
 
 
 
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Contact

 

o.robinson

 
 
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Location

 

1103Sir Michael Uren HubWhite City Campus

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Summary

 

Publications

Citation

BibTex format

@article{Robinson:2020:10.1002/hep.31483,
author = {Robinson, O},
doi = {10.1002/hep.31483},
journal = {Hepatology},
pages = {1758--1770},
title = {Prenatal exposure to perfluoroalkyl substances associated with increased susceptibility to liver Injury in children},
url = {http://dx.doi.org/10.1002/hep.31483},
volume = {72},
year = {2020}
}
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RIS format (EndNote, RefMan)

TY  - JOUR
AB  - Background and AimsPer and polyfluoroalkyl substances (PFAS) are widespread and persistent pollutants that have been shown to have hepatotoxic effects in animal models. However, human evidence is scarce. We evaluated how prenatal exposure to PFAS associates with established serum biomarkers of liver injury and alterations in serum metabolome in children.Approach and ResultsWe used data from 1,105 mothers and their children (median age, 8.2 years; interquartile range, 6.69.1) from the European Human EarlyLife Exposome cohort (consisting of six existing populationbased birth cohorts in France, Greece, Lithuania, Norway, Spain, and the United Kingdom). We measured concentrations of perfluorooctane sulfonate, perfluorooctanoate, perfluorononanoate, perfluorohexane sulfonate, and perfluoroundecanoate in maternal blood. We assessed concentrations of alanine aminotransferase, aspartate aminotransferase, and gammaglutamyltransferase in child serum. Using Bayesian kernel machine regression, we found that higher exposure to PFAS during pregnancy was associated with higher liver enzyme levels in children. We also measured child serum metabolomics through a targeted assay and found significant perturbations in amino acid and glycerophospholipid metabolism associated with prenatal PFAS. A latent variable analysis identified a profile of children at high risk of liver injury (odds ratio, 1.56; 95% confidence interval, 1.211.92) that was characterized by high prenatal exposure to PFAS and increased serum levels of branchedchain amino acids (valine, leucine, and isoleucine), aromatic amino acids (tryptophan and phenylalanine), and glycerophospholipids (phosphatidylcholine [PC] aa C36:1 and LysoPC a C18:1).ConclusionsDevelopmental exposure to PFAS can contribute to pediatric liver injury.
AU  - Robinson,O
DO  - 10.1002/hep.31483
EP  - 1770
PY  - 2020///
SN  - 0270-9139
SP  - 1758
TI  - Prenatal exposure to perfluoroalkyl substances associated with increased susceptibility to liver Injury in children
T2  - Hepatology
UR  - http://dx.doi.org/10.1002/hep.31483
UR  - https://aasldpubs.onlinelibrary.wiley.com/doi/10.1002/hep.31483
UR  - http://hdl.handle.net/10044/1/81279
VL  - 72
ER  -
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