Imperial College London
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DrOliverRobinson

Faculty of Medicine, School of Public Health

Lecturer in Molecular Epidemiology
 
 
 
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o.robinson

 
 
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1103Sir Michael Uren HubWhite City Campus

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Publications

Citation

BibTex format

@article{Warembourg:2021:10.1016/j.envint.2020.106174,
author = {Warembourg, C and Nieuwenhuijsen, M and Ballester, F and de, Castro M and Chatzi, L and Esplugues, A and Heude, B and Maitre, L and McEachan, R and Robinson, O and Slama, R and Sunyer, J and Urquiza, J and Wright, J and Basagaña, X and Vrijheid, M},
doi = {10.1016/j.envint.2020.106174},
journal = {Environment International},
title = {Urban environment during early-life and blood pressure in young children},
url = {http://dx.doi.org/10.1016/j.envint.2020.106174},
volume = {146},
year = {2021}
}
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TY  - JOUR
AB  - BackgroundThe urban environment is characterised by many exposures that may influence hypertension development from early life onwards, but there is no systematic evaluation of their impact on child blood pressure (BP).MethodsSystolic and diastolic blood pressure were measured in 4,279 children aged 4–5 years from a multi-centre European cohort (France, Greece, Spain, and UK). Urban environment exposures were estimated during pregnancy and childhood, including air pollution, built environment, natural spaces, traffic, noise, meteorology, and socioeconomic deprivation index. Single- and multiple-exposure linear regression models and a cluster analysis were carried out.ResultsIn multiple exposure models, higher child BP, in particular diastolic BP, was observed in association with higher exposure to air pollution, noise and ambient temperature during pregnancy, and with higher exposure to air pollution and higher building density during childhood (e.g., mean change [95% confidence interval] for an interquartile range increase in prenatal NO2 = 0.7 mmHg[0.3;1.2]). Lower BP was observed in association with higher temperature and better street connectivity during childhood (e.g., temperature = -1.1[-1.6;-0.6]). Some of these associations were not robust in the sensitivity analyses. Mother-child pairs were grouped into six urban environment exposure clusters. Compared to the cluster representing the least harmful urban environment, the two clusters representing the most harmful environment (high in air pollution, traffic, noise, and low in green space) were both associated with higher diastolic BP (1.3[0.1;2.6] and 1.5[0.5;2.5]).ConclusionThis first large systematic study suggests that living in a harmful urban environment may impact BP regulation in children. These findings reinforce the importance of designing cities that promote healthy environments to reduce long-term risk of hypertension and other cardiovascular diseases.
AU  - Warembourg,C
AU  - Nieuwenhuijsen,M
AU  - Ballester,F
AU  - de,Castro M
AU  - Chatzi,L
AU  - Esplugues,A
AU  - Heude,B
AU  - Maitre,L
AU  - McEachan,R
AU  - Robinson,O
AU  - Slama,R
AU  - Sunyer,J
AU  - Urquiza,J
AU  - Wright,J
AU  - Basagaña,X
AU  - Vrijheid,M
DO  - 10.1016/j.envint.2020.106174
PY  - 2021///
SN  - 0160-4120
TI  - Urban environment during early-life and blood pressure in young children
T2  - Environment International
UR  - http://dx.doi.org/10.1016/j.envint.2020.106174
UR  - http://hdl.handle.net/10044/1/84477
VL  - 146
ER  -
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