Imperial College London
Alternate

DrOliverRobinson

Faculty of Medicine, School of Public Health

Lecturer in Molecular Epidemiology
 
 
 
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o.robinson

 
 
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Location

 

1103Sir Michael Uren HubWhite City Campus

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Summary

 

Publications

Citation

BibTex format

@article{Stratakis:2021:10.1002/hep.31809,
author = {Stratakis, N and Golden-Mason, L and Margetaki, K and Zhao, Y and Valvi, D and Garcia, E and Maitre, L and Andrusaityte, S and Basagana, X and Borràs, E and Bustamante, M and Casas, M and Fossati, S and Grazuleviciene, R and Haug, LS and Heude, B and McEachan, RRC and Meltzer, HM and Papadopoulou, E and Roumeliotaki, T and Robinson, O and Sabidó, E and Urquiza, J and Vafeiadi, M and Varo, N and Wright, J and Vos, MB and Hu, H and Vrijheid, M and Berhane, KT and Conti, DV and McConnell, R and Rosen, HR and Chatzi, L},
doi = {10.1002/hep.31809},
journal = {Hepatology},
pages = {1546--1559},
title = {In utero exposure to mercury is associated with increased susceptibility to liver injury and inflammation in childhood},
url = {http://dx.doi.org/10.1002/hep.31809},
volume = {74},
year = {2021}
}
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RIS format (EndNote, RefMan)

TY  - JOUR
AB  - Nonalcoholic fatty liver disease (NAFLD) is the most prevalent cause of liver disease in children. Mercury (Hg), a ubiquitous toxic metal, has been proposed as an environmental factor contributing to toxicantassociated fatty liver disease. We investigated the effect of prenatal exposure to Hg on childhood liver injury by combining epidemiological results from a multicenter motherchild cohort with complementary in vitro experiments on monocyte cells that are known to play a key role in liver immune homeostasis and NAFLD. We used data from 872 mothers and their children (median age, 8.1 years; interquartile range [IQR], 6.58.7) from the European Human EarlyLife Exposome (HELIX) cohort. We measured Hg concentration in maternal blood during pregnancy (median, 2.0 μg/L; IQR, 1.13.6). We also assessed serum levels of alanine aminotransferase (ALT), a common screening tool for pediatric NAFLD, and plasma concentrations of inflammationrelated cytokines in children. We found that prenatal Hg exposure was associated with a phenotype in children that was characterized by elevated ALT (≥22.1 U/L for females and ≥25.8 U/L for males) and increased concentrations of circulating interleukin (IL)1β, IL6, IL8, and tumor necrosis factor α (TNFα). Consistently, inflammatory monocytes exposed in vitro to a physiologically relevant dose of Hg demonstrated significant upregulation of genes encoding these four cytokines and increased concentrations of IL8 and TNFα in the supernatants.Conclusion:These findings suggest that developmental exposure to Hg can contribute to inflammation and increased NAFLD risk in early life.
AU  - Stratakis,N
AU  - Golden-Mason,L
AU  - Margetaki,K
AU  - Zhao,Y
AU  - Valvi,D
AU  - Garcia,E
AU  - Maitre,L
AU  - Andrusaityte,S
AU  - Basagana,X
AU  - Borràs,E
AU  - Bustamante,M
AU  - Casas,M
AU  - Fossati,S
AU  - Grazuleviciene,R
AU  - Haug,LS
AU  - Heude,B
AU  - McEachan,RRC
AU  - Meltzer,HM
AU  - Papadopoulou,E
AU  - Roumeliotaki,T
AU  - Robinson,O
AU  - Sabidó,E
AU  - Urquiza,J
AU  - Vafeiadi,M
AU  - Varo,N
AU  - Wright,J
AU  - Vos,MB
AU  - Hu,H
AU  - Vrijheid,M
AU  - Berhane,KT
AU  - Conti,DV
AU  - McConnell,R
AU  - Rosen,HR
AU  - Chatzi,L
DO  - 10.1002/hep.31809
EP  - 1559
PY  - 2021///
SN  - 0270-9139
SP  - 1546
TI  - In utero exposure to mercury is associated with increased susceptibility to liver injury and inflammation in childhood
T2  - Hepatology
UR  - http://dx.doi.org/10.1002/hep.31809
UR  - https://aasldpubs.onlinelibrary.wiley.com/doi/10.1002/hep.31809
UR  - http://hdl.handle.net/10044/1/88652
VL  - 74
ER  -
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