Imperial College London
Alternate

DrOliverRobinson

Faculty of Medicine, School of Public Health

Lecturer in Molecular Epidemiology
 
 
 
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Contact

 

o.robinson

 
 
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Location

 

1103Sir Michael Uren HubWhite City Campus

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Summary

 

Publications

Citation

BibTex format

@article{Stratakis:2021:10.1111/obr.13383,
author = {Stratakis, N and Rock, S and La, Merrill MA and Saez, M and Robinson, O and Fecht, D and Vrijheid, M and Valvi, D and Conti, DV and McConnell, R and Chatzi, VL},
doi = {10.1111/obr.13383},
journal = {Obesity Reviews},
pages = {1--16},
title = {Prenatal exposure to persistent organic pollutants and childhood obesity: A systematic review and meta-analysis of human studies},
url = {http://dx.doi.org/10.1111/obr.13383},
volume = {23},
year = {2021}
}
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RIS format (EndNote, RefMan)

TY  - JOUR
AB  - We conducted a systematic review and meta-analysis of the associations between prenatal exposure to persistent organic pollutants (POPs) and childhood obesity. We focused on organochlorines (dichlorodiphenyltrichloroethane [DDT], dichlorodiphenyldichloroethylene [DDE], hexachlorobenzene [HCB], and polychlorinated biphenyls [PCBs]), perfluoroalkyl and polyfluoroalkyl substances (PFAS), and polybrominated diphenyl ethers (PBDEs) that are the POPs more widely studied in environmental birth cohorts so far. We search two databases (PubMed and Embase) through July/09/2021 and identified 33 studies reporting associations with prenatal organochlorine exposure, 21 studies reporting associations with prenatal PFAS, and five studies reporting associations with prenatal PBDEs. We conducted a qualitative review. Additionally, we performed random-effects meta-analyses of POP exposures, with data estimates from at least three prospective studies, and BMI-z. Prenatal DDE and HCB levels were associated with higher BMI z-score in childhood (beta: 0.12, 95% CI: 0.03, 0.21; I2 : 28.1% per study-specific log increase of DDE and beta: 0.31, 95% CI: 0.09, 0.53; I2 : 31.9% per study-specific log increase of HCB). No significant associations between PCB-153, PFOA, PFOS, or pentaPBDEs with childhood BMI were found in meta-analyses. In individual studies, there was inconclusive evidence that POP levels were positively associated with other obesity indicators (e.g., waist circumference).
AU  - Stratakis,N
AU  - Rock,S
AU  - La,Merrill MA
AU  - Saez,M
AU  - Robinson,O
AU  - Fecht,D
AU  - Vrijheid,M
AU  - Valvi,D
AU  - Conti,DV
AU  - McConnell,R
AU  - Chatzi,VL
DO  - 10.1111/obr.13383
EP  - 16
PY  - 2021///
SN  - 1467-7881
SP  - 1
TI  - Prenatal exposure to persistent organic pollutants and childhood obesity: A systematic review and meta-analysis of human studies
T2  - Obesity Reviews
UR  - http://dx.doi.org/10.1111/obr.13383
UR  - https://www.ncbi.nlm.nih.gov/pubmed/34766696
UR  - https://onlinelibrary.wiley.com/doi/10.1111/obr.13383
UR  - http://hdl.handle.net/10044/1/92679
VL  - 23
ER  -
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