Imperial College London
Alternate

DrOliverRobinson

Faculty of Medicine, School of Public Health

Lecturer in Molecular Epidemiology
 
 
 
//

Contact

 

o.robinson

 
 
//

Location

 

1103Sir Michael Uren HubWhite City Campus

//

Summary

 

Publications

Citation

BibTex format

@article{Robinson:2022,
author = {Robinson, O},
journal = {International Journal of Obesity},
pages = {1384--1393},
title = {Cord blood metabolites and rapid postnatal growth as multiple mediators in the prenatal propensity to childhood overweight},
url = {https://www.nature.com/articles/s41366-022-01108-0},
volume = {46},
year = {2022}
}
Download

RIS format (EndNote, RefMan)

TY  - JOUR
AB  - BACKGROUND: The mechanisms underlying childhood overweight and obesity are poorly known. Here, we investigated the direct and indirect effects of different prenatal exposures on offspring rapid postnatal growth and overweight in childhood, mediated through cord blood metabolites. Additionally, rapid postnatal growth was considered a potential mediator on childhood overweight, alone and sequentially to each metabolite.METHODS: Within four European birth-cohorts (N=375 mother-child dyads), information on seven prenatal exposures (maternal education, pre-pregnancy BMI, weight gain and tobacco smoke during pregnancy, age at delivery, parity, and child gestational age), selected as obesogenic according to a-priori knowledge, was collected. Cord blood levels of 31 metabolites, associated with rapid postnatal growth and/or childhood overweight in a previous study, were measured via liquid-chromatography-quadrupole-time-of-flight-mass-spectrometry. Rapid growth at 12 months and childhood overweight (including obesity) between four and eight years were defined with reference to WHO growth charts. Single mediation analysis was performed using the imputation approach and multiple mediation analysis using the extended-imputation approach.RESULTS: Single mediation suggested that the effect of maternal education, pregnancy weight gain, parity, and gestational age on rapid postnatal growth but not on childhood overweight was partly mediated by seven metabolites, including cholestenone, decenoylcarnitine(C10:1), phosphatidylcholine(C34:3), progesterone and three unidentified metabolites; and the effect of gestational age on childhood overweight was mainly mediated by rapid postnatal growth. Multiple mediation suggested that the effect of gestational age on childhood overweight was mainly mediated by rapid postnatal growth and that the mediating role of the metabolites was marginal. CONCLUSION: Our findings provide evidence of the involvement of in utero metabolism in the propensity
AU  - Robinson,O
EP  - 1393
PY  - 2022///
SN  - 0307-0565
SP  - 1384
TI  - Cord blood metabolites and rapid postnatal growth as multiple mediators in the prenatal propensity to childhood overweight
T2  - International Journal of Obesity
UR  - https://www.nature.com/articles/s41366-022-01108-0
UR  - http://hdl.handle.net/10044/1/95325
VL  - 46
ER  -
Download