Imperial College London
Alternate

DrOliverRobinson

Faculty of Medicine, School of Public Health

Lecturer in Molecular Epidemiology
 
 
 
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o.robinson

 
 
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Location

 

1103Sir Michael Uren HubWhite City Campus

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Summary

 

Publications

Citation

BibTex format

@article{Handakas:2022:10.3389/fgene.2022.947591,
author = {Handakas, E and Xu, Y and Blair, Segal A and Huerta, MC and Bowman, K and Howse, LD and Sassi, F and Robinson, O},
doi = {10.3389/fgene.2022.947591},
journal = {Frontiers in Genetics},
pages = {1--18},
title = {Molecular mediators of the association between child obesity and mental health},
url = {http://dx.doi.org/10.3389/fgene.2022.947591},
volume = {13},
year = {2022}
}
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RIS format (EndNote, RefMan)

TY  - JOUR
AB  - Biological mechanisms underlying the association between obesity and depression remain unclear. We investigated the role of metabolites and DNA methylation as mediators of the relationship between childhood obesity and subsequent poor mental health in the English Avon Longitudinal Study of Parents and Children. Obesity was defined according to United Kingdom Growth charts at age 7 years and mental health through the Short Mood and Feelings Questionnaire (SMFQ) completed at age 11 years. Metabolites and DNA methylation were measured by nuclear magnetic resonance spectroscopy and Illumina array in blood at the age of 7 years. The associations between obesity and SMFQ score, as continuous count data or using cut-offs to define depressive symptoms (SMFQ >7) or depression (SMFQ >11), were tested using adjusted Poisson and logistic regression. Candidate metabolite mediators were identified through metabolome-wide association scans for obesity and SMFQ score, correcting for false-discovery rate. Candidate DNA methylation mediators were identified through testing the association of putative BMI-associated CpG sites with SMFQ scores, correcting for look-up false-discovery rate. Mediation by candidate molecular markers was tested. Two-sample Mendelian randomization (MR) analyses were additionally applied to test causal associations of metabolites with depression in independent adult samples. 4,018 and 768 children were included for metabolomics and epigenetics analyses, respectively. Obesity at 7 years was associated with a 14% increase in SMFQ score (95% CI: 1.04, 1.25) and greater odds of depression (OR: 1.46 (95% CI: 0.78, 2.38) at 11 years. Natural indirect effects (mediating pathways) between obesity and depression for tyrosine, leucine and conjugated linoleic acid were 1.06 (95% CI: 1.00, 1.13, proportion mediated (PM): 15%), 1.04 (95% CI: 0.99, 1.10, PM: 9.6%) and 1.06 (95% CI: 1.00, 1.12, PM: 13.9%) respectively. In MR analysis, one unit increase in tyrosine was
AU  - Handakas,E
AU  - Xu,Y
AU  - Blair,Segal A
AU  - Huerta,MC
AU  - Bowman,K
AU  - Howse,LD
AU  - Sassi,F
AU  - Robinson,O
DO  - 10.3389/fgene.2022.947591
EP  - 18
PY  - 2022///
SN  - 1664-8021
SP  - 1
TI  - Molecular mediators of the association between child obesity and mental health
T2  - Frontiers in Genetics
UR  - http://dx.doi.org/10.3389/fgene.2022.947591
UR  - https://www.frontiersin.org/articles/10.3389/fgene.2022.947591/full
UR  - http://hdl.handle.net/10044/1/99328
VL  - 13
ER  -
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