Imperial College London
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DrOliverRobinson

Faculty of Medicine, School of Public Health

Lecturer in Molecular Epidemiology
 
 
 
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o.robinson

 
 
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1103Sir Michael Uren HubWhite City Campus

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Publications

Citation

BibTex format

@article{Alfano:2023:10.1186/s12916-022-02685-7,
author = {Alfano, R and Zugna, D and Barros, H and Bustamante, M and Chatzi, L and Ghantous, A and Herceg, Z and Keski-Rahkonen, P and de, Kok TM and Nawrot, TS and Relton, CL and Robinson, O and Roumeliotaki, T and Scalbert, A and Vrijheid, M and Vineis, P and Richiardi, L and Plusquin, M},
doi = {10.1186/s12916-022-02685-7},
journal = {BMC Medicine},
title = {Cord blood epigenome-wide meta-analysis in six European-based child cohorts identifies signatures linked to rapid weight growth},
url = {http://dx.doi.org/10.1186/s12916-022-02685-7},
volume = {21},
year = {2023}
}
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TY  - JOUR
AB  - BACKGROUND: Rapid postnatal growth may result from exposure in utero or early life to adverse conditions and has been associated with diseases later in life and, in particular, with childhood obesity. DNA methylation, interfacing early-life exposures and subsequent diseases, is a possible mechanism underlying early-life programming. METHODS: Here, a meta-analysis of Illumina HumanMethylation 450K/EPIC-array associations of cord blood DNA methylation at single CpG sites and CpG genomic regions with rapid weight growth at 1 year of age (defined with reference to WHO growth charts) was conducted in six European-based child cohorts (ALSPAC, ENVIRONAGE, Generation XXI, INMA, Piccolipiù, and RHEA, N = 2003). The association of gestational age acceleration (calculated using the Bohlin epigenetic clock) with rapid weight growth was also explored via meta-analysis. Follow-up analyses of identified DNA methylation signals included prediction of rapid weight growth, mediation of the effect of conventional risk factors on rapid weight growth, integration with transcriptomics and metabolomics, association with overweight in childhood (between 4 and 8 years), and comparison with previous findings. RESULTS: Forty-seven CpGs were associated with rapid weight growth at suggestive p-value <1e-05 and, among them, three CpGs (cg14459032, cg25953130 annotated to ARID5B, and cg00049440 annotated to KLF9) passed the genome-wide significance level (p-value <1.25e-07). Sixteen differentially methylated regions (DMRs) were identified as associated with rapid weight growth at false discovery rate (FDR)-adjusted/Siddak p-values < 0.01. Gestational age acceleration was associated with decreasing risk of rapid weight growth (p-value = 9.75e-04). Identified DNA methylation signals slightly increased the prediction of rapid weight growth in addition to conventional risk factors. Among the identified signals, three CpGs partially mediated the effect of gestational age on rapid weigh
AU  - Alfano,R
AU  - Zugna,D
AU  - Barros,H
AU  - Bustamante,M
AU  - Chatzi,L
AU  - Ghantous,A
AU  - Herceg,Z
AU  - Keski-Rahkonen,P
AU  - de,Kok TM
AU  - Nawrot,TS
AU  - Relton,CL
AU  - Robinson,O
AU  - Roumeliotaki,T
AU  - Scalbert,A
AU  - Vrijheid,M
AU  - Vineis,P
AU  - Richiardi,L
AU  - Plusquin,M
DO  - 10.1186/s12916-022-02685-7
PY  - 2023///
SN  - 1741-7015
TI  - Cord blood epigenome-wide meta-analysis in six European-based child cohorts identifies signatures linked to rapid weight growth
T2  - BMC Medicine
UR  - http://dx.doi.org/10.1186/s12916-022-02685-7
UR  - https://www.ncbi.nlm.nih.gov/pubmed/36627699
UR  - http://hdl.handle.net/10044/1/102033
VL  - 21
ER  -
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