Publications
314 results found
Kalsi H, Hakim A, Meah S, et al., 2022, Omalizumab-treated severe allergic asthmatics have comparable small airways function to healthy controls, Publisher: EUROPEAN RESPIRATORY SOC JOURNALS LTD, ISSN: 0903-1936
Chakma M, Meah S, Biddiscombe M, et al., 2022, Dry powder inhaler (DPI) resistance: human behaviour and psychology of patient inspiratory effort, Publisher: EUROPEAN RESPIRATORY SOC JOURNALS LTD, ISSN: 0903-1936
Crooks M, Russell R, Cummings H, et al., 2022, The language COPD patients use to describe exacerbations: a qualitative study, Publisher: EUROPEAN RESPIRATORY SOC JOURNALS LTD, ISSN: 0903-1936
Louis R, Satia I, Ojanguren I, et al., 2022, European Respiratory Society guidelines for the diagnosis of asthma in adults, EUROPEAN RESPIRATORY JOURNAL, Vol: 60, ISSN: 0903-1936
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- Citations: 48
Stanford GE, Jones M, Charman SC, et al., 2022, Clinimetric analysis of outcome measures for airway clearance in people with cystic fibrosis: a systematic review, Therapeutic Advances in Respiratory Disease, Vol: 16, Pages: 1-12, ISSN: 1753-4666
Background:Airway clearance techniques (ACTs) are integral to cystic fibrosis (CF) management. However, there is no consensus as to which outcome measures (OMs) are best for assessing ACT efficacy.Objectives:To summarise OMs that have been assessed for their clinimetric properties (including validity, feasibility, reliability, and reproducibility) within the context of ACT research in CF.Design and Methods:A systematic review was conducted according to Preferred Reporting Items for Systematic Review and Meta-Analysis Protocols (PRISMA) standards. Any parallel or cross-over randomised controlled trial (RCT) investigating outcome measures for ACT in the CF population were eligible for inclusion. The search was performed in five medical databases, clinicaltrials.gov, and abstracts from international CF conferences. The authors planned to independently assess study quality and risk of bias using the COnsensus-based Standards for the selection of health status Measurement InstrumeNts (COSMIN) risk of bias checklist with external validity assessment based upon study details (participants and study intervention). Two review authors (GS and MJ) independently screened search results against inclusion criteria, and further data extraction were planned but not required.Results:No completed RCTs from the 187 studies identified met inclusion criteria for the primary or post hoc secondary objective. Two ongoing trials were identified.Discussion and conclusion:This empty systematic review highlights that high-quality RCTs are urgently needed to investigate and validate the clinimetric properties of OMs used to assess ACT efficacy. With the changing demographics of CF combined with the introduction of cystic fibrosis transmembrane conductance regulator (CFTR) modulator therapies, an accurate assessment of the current benefit of ACT or the effect of ACT withdrawal is a high priority for clinical practice and future research; OMs which have been validated for this purpose are essenti
Ojanguren I, Satia I, Usmani OS, 2022, The Role of Viral Infections on Severe Asthma Exacerbations: Present and Future, ARCHIVOS DE BRONCONEUMOLOGIA, Vol: 58, Pages: 632-634, ISSN: 0300-2896
Kraft M, Richardson M, Hallmark B, et al., 2022, The role of small airway dysfunction in asthma control and exacerbations: a longitudinal, observational analysis using data from the ATLANTIS study, LANCET RESPIRATORY MEDICINE, Vol: 10, Pages: 661-668, ISSN: 2213-2600
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- Citations: 19
Dekhuijzen PNR, Levy ML, Corrigan CJ, et al., 2022, Is Inhaler Technique Adequately Assessed and Reported in Clinical Trials of Asthma and Chronic Obstructive Pulmonary Disease Therapy? A Systematic Review and Suggested Best Practice Checklist, JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY-IN PRACTICE, Vol: 10, Pages: 1813-+, ISSN: 2213-2198
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- Citations: 3
Honkoop P, Usmani O, Bonini M, 2022, The Current and Future Role of Technology in Respiratory Care, PULMONARY THERAPY, Vol: 8, Pages: 167-179, ISSN: 2364-1754
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- Citations: 1
Kocks JWH, Wouters H, Bosnic-Anticevich S, et al., 2022, Factors associated with health status and exacerbations in COPD maintenance therapy with dry powder inhalers, NPJ PRIMARY CARE RESPIRATORY MEDICINE, Vol: 32
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- Citations: 5
Moitra S, Deprato A, Usmani OS, et al., 2022, Reference Equations for Oscillometry in Adults and Their Differences Between Populations: A Systematic Scoping Review and Analysis, International Conference of the American-Thoracic-Society, Publisher: AMER THORACIC SOC, ISSN: 1073-449X
Usmani OS, Bosnic-Anticevich SZ, Dekhuijzen P, et al., 2022, Real World Impact of Non Clinical Inhaler Switching on Asthma or COPD Patients - a Systematic Review, International Conference of the American-Thoracic-Society, Publisher: AMER THORACIC SOC, ISSN: 1073-449X
Usmani OS, Han MK, Kaminsky DA, et al., 2022, Classification of Small Airways Response, CHEST, Vol: 161, Pages: E249-E250, ISSN: 0012-3692
James M, Madeira Teixeira Baptista A, Barnabas D, et al., 2022, Collaborative case-based learning with programmatic team-based assessment: a novel methodology for developing advanced skills in early-years medical students, BMC Medical Education, Vol: 22, Pages: 1-12, ISSN: 1472-6920
BackgroundImperial College London launched a new, spiral undergraduate medical curriculum in September 2019. Clinical & Scientific Integrative cases (CSI) is an innovative, flagship module, which uses pioneering methodology to provide early-years learning that [1] is patient-centred, [2] integrates clinical and scientific curriculum content, [3] develops advanced team-work skills and [4] provides engaging, student-driven learning. These aims are designed to produce medical graduates equipped to excel in a modern healthcare environment.MethodsCSI has adopted a novel educational approach which utilises contemporary digital resources to deliver a collaborative case-based learning (CBL) component, paired with a team-based learning (TBL) component that incorporates both learning and programmatic assessment. This paper serves to explore how first-year students experienced CSI in relation to its key aims, drawing upon quantitative and qualitative data from feedback surveys from CSI’s inaugural year. It provides a description and analysis of the module’s design, delivery, successes and challenges.ResultsOur findings indicate that CSI has been extremely well-received and that the majority of students agree that it met its aims. Survey outputs indicate success in integrating multiple elements of the curriculum, developing an early holistic approach towards patients, expediting the development of important team-working skills, and delivering authentic and challenging clinical problems, which our students found highly relevant. Challenges have included supporting students to adapt to a student-driven, deep learning approach.ConclusionsFirst-year students appear to have adopted a patient-centred outlook, the ability to integrate knowledge from across the curriculum, an appreciation for other team members and the self-efficacy to collaboratively tackle challenging, authentic clinical problems. Ultimately, CSI’s innovative design is attractive and pertinent t
Usmani OS, Baldi S, Warren S, et al., 2022, Lung Deposition of Inhaled Extrafine Beclomethasone Dipropionate/Formoterol Fumarate/Glycopyrronium Bromide in Healthy Volunteers and Asthma: The STORM Study, JOURNAL OF AEROSOL MEDICINE AND PULMONARY DRUG DELIVERY, ISSN: 1941-2711
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- Citations: 5
Leving MT, Kocks J, Bosnic-Anticevich S, et al., 2022, Relationship between Peak Inspiratory Flow and Patient and Disease Characteristics in Individuals with COPD-A Systematic Scoping Review, BIOMEDICINES, Vol: 10
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- Citations: 6
Leving MT, van Boven JFM, Bosnic-Anticevich SZ, et al., 2022, Suboptimal Peak Inspiratory Flow and Critical Inhalation Errors are Associated with Higher COPD-Related Healthcare Costs, INTERNATIONAL JOURNAL OF CHRONIC OBSTRUCTIVE PULMONARY DISEASE, Vol: 17, Pages: 2401-2415, ISSN: 1178-2005
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- Citations: 2
Ohar JA, Ferguson GT, Mahler DA, et al., 2022, Measuring Peak Inspiratory Flow in Patients with Chronic Obstructive Pulmonary Disease, INTERNATIONAL JOURNAL OF CHRONIC OBSTRUCTIVE PULMONARY DISEASE, Vol: 17, Pages: 79-92, ISSN: 1178-2005
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- Citations: 6
Kouri A, Dandurand RJ, Usmani OS, et al., 2021, Exploring the 175-year history of spirometry and the vital lessons it can teach us today, EUROPEAN RESPIRATORY REVIEW, Vol: 30, ISSN: 0905-9180
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- Citations: 8
Leving M, Wouters H, de la Hoz A, et al., 2021, Impact of PIF, Inhalation Technique and Medication Adherence on Health Status and Exacerbations in COPD: Protocol of a Real-World Observational Study (PIFotal COPD Study), PULMONARY THERAPY, Vol: 7, Pages: 591-606, ISSN: 2364-1754
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- Citations: 7
Lavorini F, Usmani OS, Dhand R, 2021, Aerosol delivery systems for treating obstructive airway diseases during the SARS-CoV-2 pandemic, INTERNAL AND EMERGENCY MEDICINE, Vol: 16, Pages: 2035-2039, ISSN: 1828-0447
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- Citations: 4
Rohatgi A, Meah S, Usmani OS, 2021, COPD PATIENTS' KNOWLEDGE, TRAINING AND ADHERENCE WITH INHALATION THERAPIES DURING COVID-19, Publisher: BMJ PUBLISHING GROUP, Pages: A120-A120, ISSN: 0040-6376
Usmani O, Roche N, Wahab E, et al., 2021, A scintigraphy study of budesonide/glycopyrrolate/formoterol fumarate metered dose inhaler in patients with moderate-to-very severe chronic obstructive pulmonary disease, Respiratory Research, Vol: 22, Pages: 1-12, ISSN: 1465-9921
BackgroundTriple therapy with inhaled corticosteroids/long-acting muscarinic antagonists/long-acting β2-agonists (ICS/LAMA/LABA) is recommended for patients with chronic obstructive pulmonary disease (COPD) with continued symptoms or exacerbations, despite treatment with LAMA/LABA or ICS/LABA. The pulmonary, extrathoracic, and regional lung deposition patterns of a radiolabeled ICS/LAMA/LABA triple fixed-dose combination budesonide/glycopyrrolate/formoterol fumarate (BGF 320/18/9.6 μg), delivered via a single Aerosphere metered dose inhaler (MDI) were previously assessed in healthy volunteers and showed good deposition to the central and peripheral airways (whole lung deposition: 37.7%). Here, we report the findings assessing BGF in patients with moderate-to-very severe COPD.MethodsThis phase I, single-dose, open-label gamma scintigraphy imaging study (NCT03906045) was conducted in patients with moderate-to-very severe COPD. Patients received two actuations of BGF MDI (160/9/4.8 μg per actuation) radiolabeled with technetium‑99‑pertechnetate, not exceeding 5 MBq per actuation. Immediately following each inhalation, patients performed a breath-hold of up to 10 s, then exhaled into an exhalation filter. Gamma scintigraphy imaging of the anterior and posterior views of the lungs and stomach, and a lateral head and neck view, were performed immediately after exhalation. The primary objective of the study was to assess the pulmonary deposition of BGF. Secondary objectives assessed the deposited dose of radiolabeled BGF in the oropharyngeal and stomach regions, on the actuator, and on the exhalation filter in addition to regional airway deposition patterns in the lungs.ResultsThe mean BGF emitted dose deposited in the lungs was 32.1% (standard deviation [SD] 15.6) in patients with moderate-to-very severe COPD, 35.2% (SD 12.8) in patients with moderate COPD, and 28.7% (SD 18.4) in patients with severe/very severe COPD. Overall, the mean normalized outer/inner ra
Biddiscombe MF, Usmani OS, 2021, Delivery and adherence with inhaled therapy in asthma, MINERVA MEDICA, Vol: 112, Pages: 564-572, ISSN: 0026-4806
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- Citations: 5
Baldi S, Usmani O, Warren S, et al., 2021, Lung deposition and distribution of inhaled extra fine beclomethasone dipropionate / formoterol fumarate /glycopyrronium bromide (BDP/FF/GB) in subjects with and without airflow obstruction, Publisher: EUROPEAN RESPIRATORY SOC JOURNALS LTD, ISSN: 0903-1936
Kocks J, Wouters H, Bosnic-Anticevich S, et al., 2021, Late Breaking Abstract - Factors associated with health-status of COPD patients on Dry Powder Inhaler (DPI) maintenance therapy, Publisher: EUROPEAN RESPIRATORY SOC JOURNALS LTD, ISSN: 0903-1936
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- Citations: 1
Garner JL, Biddiscombe MF, Meah S, et al., 2021, Endobronchial valve lung volume reduction and small airways function, Publisher: EUROPEAN RESPIRATORY SOC JOURNALS LTD, ISSN: 0903-1936
Biddiscombe M, Matthews J, Wright M, et al., 2021, NO EVIDENCE THAT ELECTROSTATIC CHARGE NEAR HIGH VOLTAGE POWER LINES INCREASES THE DEPOSITION OF INHALED ULTRAFINE ENVIRONMENTAL PARTICLES IN HUMAN LUNGS, Publisher: MARY ANN LIEBERT, INC, Pages: A3-A4, ISSN: 1941-2711
van Boven JFM, Dierick BJH, Usmani OS, 2021, When biology meets behaviour: can medication adherence mask the contribution of pharmacogenetic effects in asthma?, EUROPEAN RESPIRATORY JOURNAL, Vol: 58, ISSN: 0903-1936
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- Citations: 4
Usmani OS, Dhand R, Lavorini F, et al., 2021, Why We Should Target Small Airways Disease in Our Management of Chronic Obstructive Pulmonary Disease, MAYO CLINIC PROCEEDINGS, Vol: 96, Pages: 2448-2463, ISSN: 0025-6196
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- Citations: 14
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