Publications
313 results found
Vos W, Van Holsbeke C, Van Geffen W, et al., 2015, Changes in functional respiratory imaging (FRI) endpoints correlate with changes in patient reported outcomes (PRO) after recovering from acute COPD exacerbation, Publisher: EUROPEAN RESPIRATORY SOC JOURNALS LTD, ISSN: 0903-1936
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- Citations: 1
Van Holsbeke C, Vos W, Van Geffen W, et al., 2015, Improvement in FEV1 after acute COPD exacerbations are driven more by changes in hyperinflation than changes in proximal airway volume, Publisher: EUROPEAN RESPIRATORY SOC JOURNALS LTD, ISSN: 0903-1936
Hakim A, Barnes PJ, Adcock IM, et al., 2015, THE IMPACT OF DRUG CLEARANCE ON DURATION OF ACTION OF CORTICOSTEROIDS, The Aerosol Society Drug Delivery to the Lungs 25, Publisher: Mary Ann Liebert, Pages: A22-A22, ISSN: 1941-2711
Parisini I, Usmani O, Murnane D, 2015, A CLINICAL TOOL TO ASSESS INHALATION PROFILES IN PATIENTS AFFECTED BY LUNG DISEASES: PRELIMINARY RESULTS, JOURNAL OF AEROSOL MEDICINE AND PULMONARY DRUG DELIVERY, Vol: 28, Pages: A15-A16, ISSN: 1941-2711
Sherwani Y, Ahmed M, Muntasir M, et al., 2015, Examining the role of gamification and use of mHealth apps in the context of smoking cessation: A review of extant knowledge and outlook, Publisher: Imperial College Business School
Bonini M, Usmani OS, 2015, The role of the small airways in the pathophysiology of asthma and chronic obstructive pulmonary disease, Therapeutic Advances in Respiratory Disease, Vol: 9, Pages: 281-293, ISSN: 1753-4666
Chronic respiratory diseases, such as asthma and chronic obstructive pulmonary disease (COPD), represent a major social and economic burden for worldwide health systems. During recent years, increasing attention has been directed to the role of small airways in respiratory diseases, and their exact contribution to the pathophysiology of asthma and COPD continues to be clarified. Indeed, it has been suggested that small airways play a distinct role in specific disease phenotypes. Besides providing information on small airways structure and diagnostic procedures, this review therefore aims to present updated and evidence-based findings on the role of small airways in the pathophysiology of asthma and COPD. Most of the available information derives from either pathological studies or review articles and there are few data on the natural history of small airways disease in the onset or progression of asthma and COPD. Comparisons between studies on the role of small airways are hard to draw because both asthma and COPD are highly heterogeneous conditions. Most studies have been performed in small population samples, and different techniques to characterize aspects of small airways function have been employed in order to assess inflammation and remodelling. Most methods of assessing small airways dysfunction have been largely confined to research purposes, but some data are encouraging, supporting the utilization of certain techniques into daily clinical practice, particularly for early-stage diseases, when subjects are often asymptomatic and routine pulmonary function tests may be within normal ranges. In this context further clinical trials and real-life feedback on large populations are desirable.
Votis K, Kikidis D, Tzovaras D, et al., 2015, The digital patient: the future of mobile health for respiratory patients, Journal of Aerosol Medicine and Pulmonary Drug Delivery, Vol: 28, Pages: A27-A27, ISSN: 1941-2703
The wave of digital health is continuously growing and promises to transform healthcare and optimize the patients’ experience. Asthma is in the center of these digital developments, as it is a chronic disease that requires the continuous attention of both health care professionals and patients themselves. The accurate and timely assessment of the state of asthma is the fundamental basis of digital health approaches and is also the most significant factor toward the preventive and efficient management of the disease. Furthermore, the necessity of inhaled medication offers a basic platform upon which modern technologies can be integrated, namely the inhaler device itself. Inhaler based monitoring devices were introduced in the beginning of the 1980s and have been evolving but mainly for the assessment of medication adherence. As technology progresses and novel sensing components are becoming available, the enhancement of inhalers with a wider range of monitoring capabilities holds the promise to further support and optimize asthma self-management. The current paper aims to take a step for the mapping of this territory and start the discussion among healthcare professionals and engineers for the identification and the development of technologies that can offer personalized asthma self-management with clinical significance. In this direction, a technical review of inhaler based monitoring devices is presented, together with an overview of their use in clinical research. The aggregated results are then summarized and discussed for the identification of key drivers that can lead the future of inhalers.
Biddiscombe M, Matthews J, Wright M, et al., 2015, CHARACTERISATION OF A HIGH VOLTAGE CORONA CHARGER TO SIMULATE THE AEROSOL CHARGE STATE FOUND NEAR HV POWER LINES
Matthews JC, Wright MD, Biddiscombe MF, et al., 2015, Re-creation of aerosol charge state found near HV power lines using a high voltage corona charger, Conference on Electrostatics, Publisher: IOP Publishing, ISSN: 1742-6588
Hakim A, Usmani OS, 2015, Enhancing nuclear translocation: perspectives in inhaled corticosteroid therapy, THERAPEUTIC DELIVERY, Vol: 6, Pages: 443-451, ISSN: 2041-5990
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- Citations: 2
Usmani OS, 2015, Inhaled drug therapy for the management of asthma, Prescriber, Vol: 26, Pages: 23-25, ISSN: 0959-6682
There is a wide range of inhaler devices to choose from for asthma. This drug review highlights their advantages and disadvantages as well as the importance of inhaler technique.
Wu CHK, Gunasekara K, Hull JH, et al., 2015, Gabapentin as a Potential Treatment for Cough Syncope, RESPIRATORY CARE, Vol: 60, Pages: E34-E37, ISSN: 0020-1324
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- Citations: 7
Usmani OS, 2015, Small-airway disease in asthma: pharmacological considerations, CURRENT OPINION IN PULMONARY MEDICINE, Vol: 21, Pages: 55-67, ISSN: 1070-5287
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- Citations: 39
Van Geffen W, Vos W, Van Holsbeke C, et al., 2015, Exacerbation Recovery Quantified By Functional Respiratory Imaging, International Conference of the American-Thoracic-Society (ATS), Publisher: AMER THORACIC SOC, ISSN: 1073-449X
Hakim A, Usmani OS, 2014, Structure of the Lower Respiratory Tract, Reference Module in Biomedical Research, ISBN: 9780128012383
© 2014 Elsevier Inc. All rights reserved.The respiratory system is essential for supplying the body with oxygen and removing carbon dioxide. It is mainly responsible for pulmonary ventilation, movement of air into and out of the lungs, and external respiration. The respiratory system consists of the chest wall structures responsible for moving air in and out of the lungs and the airways that carry the air to the alveoli, which are the gas exchanging region of the lung. The airways themselves are subdivided into two major regions, the upper and lower respiratory tracts. The lower respiratory tract includes the larynx, trachea, bronchi, bronchioles, and alveoli. These structural features facilitate maximum delivery of air to all parts of the lungs as well as providing maximal surface area for gaseous exchange, which is aided by the richly perfused source of blood and lymphatic vessels.
McNulty W, Usmani OS, 2014, Techniques of assessing small airways dysfunction, European Clinical Respiratory Journal, Vol: 1, ISSN: 2001-8525
The small airways are defined as those less than 2 mm in diameter. They are a major site of pathology in many lung diseases, not least chronic obstructive pulmonary disease (COPD) and asthma. The small airways are frequently involved early in the course of these diseases, with significant pathology demonstrable often before the onset of symptoms or changes in spirometry and imaging. Despite their importance, they have proven relatively difficult to study. This is in part due to their relative inaccessibility to biopsy and their small size which makes their imaging difficult. Traditional lung function tests may only become abnormal once there is a significant burden of disease within them. This has led to the term ‘the quiet zone’ of the lung. In recent years, more specialised tests have been developed which may detect these changes earlier, perhaps offering the possibility of earlier diagnosis and intervention. These tests are now moving from the realms of clinical research laboratories into routine clinical practice and are increasingly useful in the diagnosis and monitoring of respiratory diseases. This article gives an overview of small airways physiology and some of the routine and more advanced tests of airway function.
Usmani OS, 2014, Small airways dysfunction in asthma: evaluation and management to improve asthma control, Allergy, asthma & immunology research, Vol: 6, Pages: 376-388, ISSN: 2092-7363
The small airways have been neglected for many years, but interest in the topic has been rekindled with recent advances in measurement techniques to assess this region and also the ability to deliver therapeutics to the distal airways. Current levels of disease control in asthmatic patients remain poor and there are several contributory factors including; poor treatment compliance, heterogeneity of asthma phenotypes and associated comorbidities. However, the proposition that we may not be targeting all the inflammation that is present throughout the whole respiratory tree may also be an important factor. Indeed decades ago, pathologists and physiologists clearly identified the importance of small airways dysfunction in asthmatic patients. With improved inhaler technology to deliver drug to target the whole respiratory tree and more sensitive measures to assess the distal airways, we should certainly give greater consideration to treating the small airway region when seeing our asthmatic patients in clinic. The aim of this review is to address the relevance of small airways dysfunction in the daily clinical management of patients with asthma. In particular the role of small particle aerosols in the management of patients with asthma will be explored.
Olley A, Chung KF, Usmani O, et al., 2014, Physiotherapy for breathing pattern dysfunction in chronic refractoly cough - Don't hold your breath, Publisher: EUROPEAN RESPIRATORY SOC JOURNALS LTD, ISSN: 0903-1936
Bonini M, Hull J, Meah S, et al., 2014, Small airways and exercise-induced bronchoconstriction (EIB) in elite athletes, Publisher: EUROPEAN RESPIRATORY SOC JOURNALS LTD, ISSN: 0903-1936
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- Citations: 1
Karagiannis K, Bikov A, Bonifazi M, et al., 2014, Impulse oscillometry measurements are correlated to quality of life in patients with pulmonary sarcoidosis, Publisher: EUROPEAN RESPIRATORY SOC JOURNALS LTD, ISSN: 0903-1936
Corradi M, Chrystyn H, Cosio BG, et al., 2014, NEXThaler, an innovative dry powder inhaler delivering an extrafine fixed combination of beclometasone and formoterol to treat large and small airways in asthma, EXPERT OPINION ON DRUG DELIVERY, Vol: 11, Pages: 1497-1506, ISSN: 1742-5247
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- Citations: 63
Bjermer L, Alving K, Diamant Z, et al., 2014, Current evidence and future research needs for FeNO measurement in respiratory diseases, RESPIRATORY MEDICINE, Vol: 108, Pages: 830-841, ISSN: 0954-6111
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- Citations: 138
Paredi P, Kharitonov SA, Meah S, et al., 2014, A Novel Approach to Partition Central and Peripheral Airway Nitric Oxide, CHEST, Vol: 145, Pages: 113-119, ISSN: 0012-3692
Khan YM, Hakim A, Down G, et al., 2014, Novel engineered drug formulations of beta 2-agonist and corticosteroid reduce LPS-induced inflammation in a human monocytic cell line (thp-1), American Thoracic Society 2014 International Conference
Hakim A, Khan YM, Barnes PJ, et al., 2014, The Importin-7 Pathway, A Novel Target For Regulating Corticosteroid Sensitivity, Is Impaired In Corticosteroid Insensitivity, AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE, Vol: 189, ISSN: 1073-449X
Lavorini F, Fontana GA, Usmani OS, 2014, New Inhaler Devices - The Good, the Bad and the Ugly, RESPIRATION, Vol: 88, Pages: 3-15, ISSN: 0025-7931
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- Citations: 96
Renzoni E, Karagiannis K, Bikov A, et al., 2014, Impulse Oscillometry Is More Tightly Linked To Symptoms And Quality Of Life Than Conventional Lung Function Measures In Pulmonary Sarcoidosis, AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE, Vol: 189, ISSN: 1073-449X
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- Citations: 1
Usmani OS, 2014, New Developments in Inhaled Drugs: Within and Beyond the Lungs, RESPIRATION, Vol: 88, Pages: 1-2, ISSN: 0025-7931
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- Citations: 3
Biddiscombe MF, Murdoch RD, Allen A, et al., 2014, Aerosol Particle Size Influences The Fate Of Inhaled Corticosteroids In Asthma, AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE, Vol: 189, ISSN: 1073-449X
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- Citations: 2
Gastaldi AC, Tawar A, Paredi P, et al., 2014, Acute Effects Of Flutter Breathing Exercises On Airway Resistance And Exhaled Nitric Oxide In COPD Patients, AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE, Vol: 189, ISSN: 1073-449X
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