Publications
313 results found
Lavorini F, Usmani OS, 2013, Correct inhalation technique is critical in achieving good asthma control, Primary Care Respiratory Journal, Vol: 22, Pages: 385-386, ISSN: 1471-4418
Hull JH, Backer V, Ward S, et al., 2013, LARYNGEAL OBSTRUCTION DURING EXERCISE IS PREVALENT IN SEVERE ASTHMA, Winter Meeting of the British-Thoracic-Society, Publisher: BMJ PUBLISHING GROUP, Pages: A50-A50, ISSN: 0040-6376
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- Citations: 2
Haque R, Hakim A, Moodley T, et al., 2013, Inhaled long-acting β<sub>2</sub> agonists enhance glucocorticoid receptor nuclear translocation and efficacy in sputum macrophages in COPD, JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY, Vol: 132, Pages: 1166-1173, ISSN: 0091-6749
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- Citations: 38
Hakim A, Barnes PJ, Adcock IM, et al., 2013, Importin-7 mediates glucocorticoid receptor nuclear import and is impaired by oxidative stress, leading to glucocorticoid insensitivity, FASEB JOURNAL, Vol: 27, Pages: 4510-4519, ISSN: 0892-6638
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- Citations: 39
Biddiscombe M, Kalsi H, Meah S, et al., 2013, The fate of inhaled drug: Corticosteroid particle size effects in asthma, EUROPEAN RESPIRATORY JOURNAL, Vol: 42, ISSN: 0903-1936
Hakim A, Barnes P, Adcock I, et al., 2013, Importin-7 knockdown reduces corticosteroid induced glucocorticoid receptor nuclear localisation and suppression of IL-1β induced CXCL8, EUROPEAN RESPIRATORY JOURNAL, Vol: 42, ISSN: 0903-1936
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- Citations: 1
Gastaldi AC, Usmani O, Barnes PJ, et al., 2013, Acute effects of flutter breathing exercises on exhaled nitric oxide and airway resistance, EUROPEAN RESPIRATORY JOURNAL, Vol: 42, ISSN: 0903-1936
Talwar A, Gastaldi A, Usmani O, et al., 2013, Standardization of the two compartment model for the partitioning of exhaled NO: Effect of different flows and breath-hold periods, EUROPEAN RESPIRATORY JOURNAL, Vol: 42, ISSN: 0903-1936
Wright MD, Matthews JC, Biddiscombe MF, et al., 2013, LUNG DEPOSITION OF CHARGED AEROSOL PARTICLES - CHARGE CHARACTERISATION USING ELPI AND HUMAN VOLUNTEER STUDY, JOURNAL OF AEROSOL MEDICINE AND PULMONARY DRUG DELIVERY, Vol: 26, Pages: A252-A252, ISSN: 1941-2711
Smaldone G, Berkland C, Gonda I, et al., 2013, Ask the experts: the benefits and challenges of pulmonary drug delivery., Ther Deliv, Vol: 4, Pages: 905-913, ISSN: 2041-5990
The field of pulmonary drug delivery is ever progressing with technological advances in inhaler device design, the development of increasingly sophisticated techniques in targeted delivery and new opportunities in drug formulation, largely as a product of the rapidly advancing area of nanotechnology. Though pulmonary administration offers numerous advantages in terms of both local and systemic drug delivery, the translation of inhaled drugs from bench-to-bedside presents an ongoing challenge. Hannah Coaker, Assistant Commissioning Editor, spoke to six experts and discussed their motivations for becoming involved in the field, major obstacles in aerosol drug development and the evolving area of pulmonary drug delivery.
Bikov A, Paschalaki K, Logan-Sinclair R, et al., 2013, Standardised exhaled breath collection for the measurement of exhaled volatile organic compounds by proton transfer reaction mass spectrometry, BMC Pulmonary Medicine, Vol: 13, Pages: 1-7, ISSN: 1471-2466
BackgroundExhaled breath volatile organic compound (VOC) analysis for airway disease monitoring is promising. However, contrary to nitric oxide the method for exhaled breath collection has not yet been standardized and the effects of expiratory flow and breath-hold have not been sufficiently studied. These manoeuvres may also reveal the origin of exhaled compounds.Methods15 healthy volunteers (34 ± 7 years) participated in the study. Subjects inhaled through their nose and exhaled immediately at two different flows (5 L/min and 10 L/min) into methylated polyethylene bags. In addition, the effect of a 20 s breath-hold following inhalation to total lung capacity was studied. The samples were analyzed for ethanol and acetone levels immediately using proton-transfer-reaction mass-spectrometer (PTR-MS, Logan Research, UK).ResultsEthanol levels were negatively affected by expiratory flow rate (232.70 ± 33.50 ppb vs. 202.30 ± 27.28 ppb at 5 L/min and 10 L/min, respectively, p < 0.05), but remained unchanged following the breath hold (242.50 ± 34.53 vs. 237.90 ± 35.86 ppb, without and with breath hold, respectively, p = 0.11). On the contrary, acetone levels were increased following breath hold (1.50 ± 0.18 ppm) compared to the baseline levels (1.38 ± 0.15 ppm), but were not affected by expiratory flow (1.40 ± 0.14 ppm vs. 1.49 ± 0.14 ppm, 5 L/min vs. 10 L/min, respectively, p = 0.14). The diet had no significant effects on the gasses levels which showed good inter and intra session reproducibility.ConclusionsExhalation parameters such as expiratory flow and breath-hold may affect VOC levels significantly; therefore standardisation of exhaled VOC measurements is mandatory. Our preliminary results suggest a different origin in the respiratory tr
Kalsi HS, Biddiscombe MF, Meah S, et al., 2013, THERAPEUTIC AEROSOL PARTICLE DEPOSITION IN COMPARTMENTS OF THE EXTRA-THORACIC AIRWAY: COMPARISON OF <i>IN VIVO</i> AND <i>IN VITRO</i>, JOURNAL OF AEROSOL MEDICINE AND PULMONARY DRUG DELIVERY, Vol: 26, Pages: A36-A37, ISSN: 1941-2711
Biddiscombe MF, Verbanck S, Kalsi H, et al., 2013, THE MULTIPLE BREATH WASHOUT TEST AS A TOOL FOR ASSESSING PERIPHERALLY TARGETED THERAPEUTIC DRUGS: ESTABLISHING A NORMAL RANGE IN HEALTHY VOLUNTEERS, JOURNAL OF AEROSOL MEDICINE AND PULMONARY DRUG DELIVERY, Vol: 26, Pages: A27-A28, ISSN: 1941-2711
Kalsi HS, Biddiscombe MF, Usmani OS, 2013, MONODISPERSE AEROSOL DEPOSITION IN COMPARTMENTS OF THE EXTRA-THORACIC AIRWAY: <i>IN VIVO</i>, JOURNAL OF AEROSOL MEDICINE AND PULMONARY DRUG DELIVERY, Vol: 26, Pages: A25-A25, ISSN: 1941-2711
Usmani OS, 2013, Treatment of small airways involvement in asthma: Clinical results, Hot Topics in Respiratory Medicine, Pages: 13-17, ISSN: 1973-9664
The small airways are currently a hot topic in the respiratory world. This airways region has long been known as the "quiet zone" of the lung, but a recent resurgence of interest by researchers using modified respiratory physiological techniques from the past and novel imaging modalities, has now allowed clinicians to (1) assess the presence of disease in this region and, in particular, (2) determine airway responses from inhaled therapy directed to this region. This review addresses the role of the small airways in asthma and the effect of treatment of this region by small particles of inhaled corticosteroid on clinical outcomes in patients with asthma, with a focus on the novel corticosteroid formulation of ciclesonide. © FBCommunication - Modena (Italy).
Hakim A, Adcock IM, Usmani O, 2013, Leptomycin B Is Unable To Prevent The Loss Of Budesonide (bud)-Induced Gr Nuclear Localisation Following A 20h Bud Washout, AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE, Vol: 187, ISSN: 1073-449X
Newman S, Bennett WD, Biddiscombe M, et al., 2012, Standardization of Techniques for Using Planar (2D) Imaging for Aerosol Deposition Assessment of Orally Inhaled Products, JOURNAL OF AEROSOL MEDICINE AND PULMONARY DRUG DELIVERY, Vol: 25, Pages: S10-S28, ISSN: 1941-2711
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- Citations: 79
Biddiscombe MF, Usmani OS, 2012, The importance of imaging and physiology measurements in assessing the delivery of peripherally targeted aerosolized drugs., Ther Deliv, Vol: 3, Pages: 1329-1345, ISSN: 2041-5990
Considerable recent effort has been directed towards developing new aerosol formulations and delivery devices that can target drugs to the lung periphery. In order to determine the efficacy of targeted drug therapy, it is essential that the peripheral lung region be adequately assessed. Imaging of the airways structure and pathology has greatly advanced in the last decade and this rate of growth is accelerating as new technologies become available. Lung imaging continues to play an important role in the study of the peripheral airways and, when combined with state-of-the-art lung function measurements and computational modeling, can be a powerful tool for investigating the effects of inhaled medication. This article focuses on recent strategies in imaging and physiological measurements of the lungs that allow the assessment of inhaled medication delivered to the periphery and discusses how these methods may help to further optimize and refine future aerosol delivery technology.
Siddiqui S, Usmani OS, 2012, Small airways, big challenge: measuring the unseen?, NATURE MEDICINE, Vol: 18, Pages: 1619-1621, ISSN: 1078-8956
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- Citations: 9
Bikov A, Paschalaki K, Kharitonov S, et al., 2012, Expiratory flow rate and breath hold affect exhaled volatile organic compounds (VOC) in healthy subjects, Publisher: EUROPEAN RESPIRATORY SOC JOURNALS LTD, ISSN: 0903-1936
Paredi P, Kharitonov SA, Barnes PJ, et al., 2012, A simple practical method to partition lung peripheral and airway nitric oxide, Publisher: EUROPEAN RESPIRATORY SOC JOURNALS LTD, ISSN: 0903-1936
Bikov A, Usmani O, Pride N, et al., 2012, Detection of air leaks and their effects on forced oscillometry measurements, Publisher: EUROPEAN RESPIRATORY SOC JOURNALS LTD, ISSN: 0903-1936
Verbanck S, Thompson BR, Schuermans D, et al., 2012, Ventilation heterogeneity in the acinar and conductive zones of the normal ageing lung, THORAX, Vol: 67, Pages: 789-795, ISSN: 0040-6376
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- Citations: 90
Mercado N, Hakim A, Kobayashi Y, et al., 2012, Restoration of corticosteroid sensitivity by p38 Mitogen activated protein kinase inhibition in peripheral blood mononuclear cells from severe asthma, PLoS One, Vol: 7, Pages: 1-9, ISSN: 1932-6203
BackgroundSevere asthma accounts for a small number of asthmatics but represents a disproportionate cost to health care systems. The underlying mechanism in severe asthma remains unknown but several mechanisms are likely to be involved because of a very heterogeneous profile. We investigated the effects of a p38MAPK inhibitor in corticosteroid sensitivity in peripheral blood mononuclear cells (PBMCs) from severe asthmatics and the profile of its responders.Methodology/Principal FindingsCorticosteroid sensitivity was determined by measuring dexamethasone inhibition of CD3/28 and TNF-α induced IL-8 production in PBMCs by using ELISA. PBMCs from severe asthmatics were relatively less sensitive to dexamethasone (Dex) as compared to those of non-severe asthmatics and healthy volunteers. The IC50 values of Dex negatively correlated with decreased glucocorticoid receptor (GR) nuclear translocation assessed using immunocytochemistry (r = −0.65; p<0.0005) and with decreased FEV1 (% predicted) (r = 0.6; p<0.0005). A p38α/β inhibitor (SB203580) restored Dex-sensitivity in a subpopulation of severe asthma that was characterized by a defective GR nuclear translocation, clinically by lower FEV1 and higher use of oral prednisolone. We also found that SB203580 partially inhibited GR phosphorylation at serine 226, resulting in increased GR nuclear translocation in IL-2/IL-4 treated corticosteroid insensitive U937s.Conclusions/Significancep38MAPKα/β is involved in defective GR nuclear translocation due to phosphorylation at Ser226 and this will be a useful biomarker to identify responders to p38MAPKα/β inhibitor in the future.
Thompson BR, Verbanck S, Schuermans D, et al., 2012, AGE DEPENDENCE OF SMALL AIRWAYS VENTILATION HETEROGENEITY, RESPIROLOGY, Vol: 17, Pages: 5-5, ISSN: 1323-7799
Parikh D, Burns J, Hipkiss D, et al., 2012, Improved localised lung delivery using smart combination respiratory medicines, European Respiratory Disease, Vol: 8, Pages: 40-45, ISSN: 1754-5552
Combination therapies for the treatment of chronic obstructive pulmonary disease (COPD) have long been used to provide improved disease management. Current therapies aim to provide bronchodilatation and most of them are based on β-agonists or anticholinergics/muscarinics. A widely used combination is an inhaled corticosteroid (ICS) plus a long-acting β-agonist (LABA), which have shown an additive improvement in lung function. However, for inhalation combination products, the most significant pharmaceutical challenge is to maintain a constant ratio of drug components during various stages of drug formulation and drug delivery. Drug delivery to lungs with a consistent and predesigned ratio of co-associated active components can help maximise the chance of co-location at the active site and hence increases the potential of synergistic action from the solid. Newer particle engineering-led approaches, such as constructive sonocrystallisation particle engineering, can help design these smart medicines that can help achieve consistent localised delivery. © Touch Briefings 2012.
Usmani OS, Barnes PJ, 2012, Assessing and treating small airways disease in asthma and chronic obstructive pulmonary disease, ANNALS OF MEDICINE, Vol: 44, Pages: 146-156, ISSN: 0785-3890
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- Citations: 68
Usmani OS, 2012, Treating the Small Airways, RESPIRATION, Vol: 84, Pages: 441-453, ISSN: 0025-7931
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- Citations: 54
Hakim A, Adcock IM, Usmani OS, 2012, Corticosteroid Resistance and Novel Anti-Inflammatory Therapies in Chronic Obstructive Pulmonary Disease Current Evidence and Future Direction, DRUGS, Vol: 72, Pages: 1299-1312, ISSN: 0012-6667
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- Citations: 30
Usmani OS, 2012, Unravelling the Small Airways: Structure-Function-Treatment Relationships in Asthma and COPD, RESPIRATION, Vol: 84, Pages: 1-3, ISSN: 0025-7931
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- Citations: 8
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