Oliver Howes is Group Head and Professor of Molecular Psychiatry. His clinical work is as Consultant Psychiatrist at The Institute of Psychiatry/ Maudsley Hospital.
Contact: tel: +44 (0)20 8383 3298
Mental illnesses are a major cause of ill health and premature death. They account for four of the six leading causes of adult disability in the world and one in every ten hospital beds in the UK is allocated for the treatment of psychotic disorders such as schizophrenia.
“Our research focuses on understanding the causes of mental illnesses and improving their treatment using PET and other functional imaging techniques"
Current work in the group focuses on:
- Understanding the brain changes that lead to the development of psychotic disorders, using multi-modal imaging with PET and MRI
- Examining the effects of cannabis and other drugs on the brain, and the influence of common genetic polymorphisms on brain function
- Determining why some patients respond to treatments and others don’t
- Using novel approaches to diagnosing mental illnesses
- Developing models for future drug development
et al., 2020, Application of SWATH mass spectrometry in the identification of circulating proteins does not predict future weight gain in early psychosis, Clinical Proteomics, Vol:17, ISSN:1542-6416
et al., 2020, The neurobiology of treatment-resistant schizophrenia: paths to antipsychotic resistance and a roadmap for future research, Npj Schizophrenia, Vol:6
et al., 2020, The magnitude and heterogeneity of antidepressant response in depression: A meta-analysis of over 45,000 patients., J Affect Disord, Vol:276, Pages:991-1000
et al., 2020, Proton Magnetic Resonance Spectroscopy of N-acetyl Aspartate in Chronic Schizophrenia, First Episode of Psychosis and High-Risk of Psychosis: A Systematic Review and Meta-Analysis., Neurosci Biobehav Rev, Vol:119, Pages:255-267
et al., 2020, The role of dopamine dysregulation and evidence for the transdiagnostic nature of elevated dopamine synthesis in psychosis: a positron emission tomography (PET) study comparing schizophrenia, delusional disorder, and other psychotic disorders., Neuropsychopharmacology, Vol:45, Pages:1870-1876