Oliver Howes is Group Head and Professor of Molecular Psychiatry. His clinical work is as Consultant Psychiatrist at The Institute of Psychiatry/ Maudsley Hospital.
Contact: tel: +44 (0)20 8383 3298
Mental illnesses are a major cause of ill health and premature death. They account for four of the six leading causes of adult disability in the world and one in every ten hospital beds in the UK is allocated for the treatment of psychotic disorders such as schizophrenia.
“Our research focuses on understanding the causes of mental illnesses and improving their treatment using PET and other functional imaging techniques"
Current work in the group focuses on:
- Understanding the brain changes that lead to the development of psychotic disorders, using multi-modal imaging with PET and MRI
- Examining the effects of cannabis and other drugs on the brain, and the influence of common genetic polymorphisms on brain function
- Determining why some patients respond to treatments and others don’t
- Using novel approaches to diagnosing mental illnesses
- Developing models for future drug development
et al., 2020, The neurobiology of treatment-resistant schizophrenia: paths to antipsychotic resistance and a roadmap for future research, Npj Schizophrenia, Vol:6
et al., 2020, Variability in Action Selection Relates to Striatal Dopamine 2/3 Receptor Availability in Humans: A PET Neuroimaging Study Using Reinforcement Learning and Active Inference Models., Cereb Cortex, Vol:30, Pages:3573-3589
et al., 2020, Practical issues and limitations of brain attenuation correction on a simultaneous PET-MR scanner, Ejnmmi Physics, Vol:7, ISSN:2197-7364
et al., 2020, GABA-A receptor differences in schizophrenia: a positron emission tomography study using [C-11]Ro154513, Molecular Psychiatry, ISSN:1359-4184
et al., 2020, Neural Circuitry of Novelty Salience Processing in Psychosis Risk: Association With Clinical Outcome., Schizophr Bull, Vol:46, Pages:670-679