Imperial College London
Alternate

DrOliverRatmann

Faculty of Natural Sciences, Department of Mathematics

Reader in Statistics and Machine Learning for Public Good
 
 
 
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oliver.ratmann05 Website

 
 
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525Huxley BuildingSouth Kensington Campus

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Summary

 

Publications

Citation

BibTex format

@article{Novitsky:2020:infdis/jiaa276,
author = {Novitsky, V and Zahralban-Steele, M and Moyo, S and Nkhisang, T and Maruapula, D and McLane, MF and Leidner, J and Bennett, K and Consortium, P and Wirth, KE and Gaolathe, T and Kadima, E and Chakalisa, U and Holme, MP and Lockman, S and Mmalane, M and Makhema, J and Gaseitsiwe, S and DeGruttola, V and Essex, M},
doi = {infdis/jiaa276},
journal = {Journal of Infectious Diseases},
pages = {1670--1680},
title = {Mapping of HIV-1C transmission networks reveals extensive spread of viral lineages across villages in Botswana treatment-as-prevention trial},
url = {http://dx.doi.org/10.1093/infdis/jiaa276},
volume = {222},
year = {2020}
}
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RIS format (EndNote, RefMan)

TY  - JOUR
AB  - BackgroundPhylogenetic mapping of HIV-1 lineages circulating across defined geographical locations is promising for better understanding HIV transmission networks to design optimal prevention interventions.MethodsWe obtained near full-length HIV-1 genome sequences from people living with HIV (PLWH), including participants on antiretroviral treatment in the Botswana Combination Prevention Project, conducted in 30 Botswana communities in 2013–2018. Phylogenetic relationships among viral sequences were estimated by maximum likelihood.ResultsWe obtained 6078 near full-length HIV-1C genome sequences from 6075 PLWH. We identified 984 phylogenetically distinct HIV-1 lineages (molecular HIV clusters) circulating in Botswana by mid-2018, with 2–27 members per cluster. Of these, dyads accounted for 62%, approximately 32% (n=316) were found in single communities, and 68% (n=668) were spread across multiple communities. Men in clusters were approximately 3 years older than women (median age 42 years, vs 39 years; P<.0001). In 65% of clusters, men were older than women, while in 35% of clusters women were older than men. The majority of identified viral lineages were spread across multiple communities.ConclusionsA large number of circulating phylogenetically distinct HIV-1C lineages (molecular HIV clusters) suggests highly diversified HIV transmission networks across Botswana communities by 2018.
AU  - Novitsky,V
AU  - Zahralban-Steele,M
AU  - Moyo,S
AU  - Nkhisang,T
AU  - Maruapula,D
AU  - McLane,MF
AU  - Leidner,J
AU  - Bennett,K
AU  - Consortium,P
AU  - Wirth,KE
AU  - Gaolathe,T
AU  - Kadima,E
AU  - Chakalisa,U
AU  - Holme,MP
AU  - Lockman,S
AU  - Mmalane,M
AU  - Makhema,J
AU  - Gaseitsiwe,S
AU  - DeGruttola,V
AU  - Essex,M
DO  - infdis/jiaa276
EP  - 1680
PY  - 2020///
SN  - 0022-1899
SP  - 1670
TI  - Mapping of HIV-1C transmission networks reveals extensive spread of viral lineages across villages in Botswana treatment-as-prevention trial
T2  - Journal of Infectious Diseases
UR  - http://dx.doi.org/10.1093/infdis/jiaa276
UR  - https://www.webofscience.com/api/gateway?GWVersion=2&SrcApp=PARTNER_APP&SrcAuth=LinksAMR&KeyUT=WOS:000605980300017&DestLinkType=FullRecord&DestApp=ALL_WOS&UsrCustomerID=a2bf6146997ec60c407a63945d4e92bb
UR  - https://academic.oup.com/jid/article/222/10/1670/5850911
VL  - 222
ER  -
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