Publications
221 results found
Anand P, 2003, Capsaicin and menthol in the treatment of itch and pain: recently cloned receptors provide the key, GUT, Vol: 52, Pages: 1233-1235, ISSN: 0017-5749
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- Citations: 23
Taherzadeh O, Otto WR, Anand U, et al., 2003, Influence of human skin injury on regeneration of sensory neurons, CELL AND TISSUE RESEARCH, Vol: 312, Pages: 275-280, ISSN: 0302-766X
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- Citations: 16
Arnold SJ, Facer P, Yiangou Y, et al., 2003, Decreased potassium channel IK1 and its regulator neurotrophin-3 (NT-3) in inflamed human bowel, NEUROREPORT, Vol: 14, Pages: 191-195, ISSN: 0959-4965
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- Citations: 19
Chan CLH, Facer P, Davis JB, et al., 2003, Sensory fibres expressing capsaicin receptor TRPV1 in patients with rectal hypersensitivity and faecal urgency, LANCET, Vol: 361, Pages: 385-391, ISSN: 0140-6736
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- Citations: 255
Renton T, Yiangou Y, Baecker PA, et al., 2003, Capsaicin receptor VR1 and ATP purinoceptor P2X<sub>3</sub> in painful and nonpainful human tooth pulp, JOURNAL OF OROFACIAL PAIN, Vol: 17, Pages: 245-250, ISSN: 1064-6655
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- Citations: 66
Chen B, Knowles CH, Scott M, et al., 2002, Idiopathic slow transit constipation and megacolon are not associated with neurturin mutations., Neurogastroenterol Motil, Vol: 14, Pages: 513-517, ISSN: 1350-1925
Chronic idiopathic slow-transit constipation (ISTC) and idiopathic megacolon (IMC) are early-onset gastrointestinal motility disorders of unknown aetiology. The gene encoding the neurotrophic factor neurturin may be a candidate for these disorders, as neurturin-deficient mice have a similar enteric phenotype. In the present study, we tested this hypothesis. Genomic DNA from 26 cases of chronic idiopathic STC [with a family history of constipation in 15 (58%) and Hirschsprung's disease in two (8%)], and five cases of IMC [two familial (40%)] was screened by direct DNA sequencing using the fluorescent dideoxy terminator method. Results were compared with published sequence data and 24 control DNAs. Our results revealed several previously unreported common sequence polymorphisms, but overall frequencies were comparable between patients and controls. We conclude that mutation of neurturin is not a frequent cause of ISTC or IMC.
Xiao YY, Segal MR, Rabert D, et al., 2002, Assessment of differential gene expression in human peripheral nerve injury, BMC Genomics, Vol: 3, Pages: 1-11, ISSN: 1471-2164
BackgroundMicroarray technology is a powerful methodology for identifying differentially expressed genes. However, when thousands of genes in a microarray data set are evaluated simultaneously by fold changes and significance tests, the probability of detecting false positives rises sharply. In this first microarray study of brachial plexus injury, we applied and compared the performance of two recently proposed algorithms for tackling this multiple testing problem, Significance Analysis of Microarrays (SAM) and Westfall and Young step down adjusted p values, as well as t-statistics and Welch statistics, in specifying differential gene expression under different biological states.ResultsUsing SAM based on t statistics, we identified 73 significant genes, which fall into different functional categories, such as cytokines / neurotrophin, myelin function and signal transduction. Interestingly, all but one gene were down-regulated in the patients. Using Welch statistics in conjunction with SAM, we identified an additional set of up-regulated genes, several of which are engaged in transcription and translation regulation. In contrast, the Westfall and Young algorithm identified only one gene using a conventional significance level of 0.05.ConclusionIn coping with multiple testing problems, Family-wise type I error rate (FWER) and false discovery rate (FDR) are different expressions of Type I error rates. The Westfall and Young algorithm controls FWER. In the context of this microarray study, it is, seemingly, too conservative. In contrast, SAM, by controlling FDR, provides a promising alternative. In this instance, genes selected by SAM were shown to be biologically meaningful.
Yiangou Y, Facer P, Sinicropi DV, et al., 2002, Molecular forms of NGF in human and rat neuropathic tissues: decreased NGF precursor-like immunoreactivity in human diabetic skin, JOURNAL OF THE PERIPHERAL NERVOUS SYSTEM, Vol: 7, Pages: 190-197, ISSN: 1085-9489
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- Citations: 34
Smith GD, Gunthorpe J, Kelsell RE, et al., 2002, TRPV3 is a temperature-sensitive vanilloid receptor-like protein, NATURE, Vol: 418, Pages: 186-190, ISSN: 0028-0836
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- Citations: 604
Holmes S, Hardee P, Anand P, 2002, Use of an orthopaedic fixator for external fixation of the mandible., Br J Oral Maxillofac Surg, Vol: 40, Pages: 238-240, ISSN: 0266-4356
A patient presented with a chronically infected, non-united fracture of the mandible, with considerable bone loss. He was treated with a metacarpal fixator, the miniPennig external fixator. The fixator is stable and smaller than conventional mandibular fixators. It can be applied and removed under local anaesthesia, if necessary, requires little maintenance and produces minimal scarring. The successful outcome in this patient is encouraging and we commend the use of the fixator in similar difficult cases.
Boettger MK, Till S, Chen AX, et al., 2002, Calcium-activated potassium channel SK1- and IK1-like immunoreactivity in injured human sensory neurones and its regulation by neurotrophic factors, BRAIN, Vol: 125, Pages: 252-263, ISSN: 0006-8950
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- Citations: 75
Bucknill AT, Coward K, Plumpton C, et al., 2002, Nerve fibers in lumbar spine structures and injured spinal roots express the sensory neuron-specific sodium channels SNS/PN3 and NaN/SNS2, SPINE, Vol: 27, Pages: 135-140, ISSN: 0362-2436
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- Citations: 32
Anand P, Birch R, 2002, Restoration of sensory function and lack of longterm chronic pain syndromes after brachial plexus injury in human neonates, BRAIN, Vol: 125, Pages: 113-122, ISSN: 0006-8950
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- Citations: 130
Kuesgen B, Frankel HL, Anand P, 2002, Decreased cutaneous sensory axon-reflex vasodilatation below the lesion in patients with complete spinal cord injury, SOMATOSENSORY AND MOTOR RESEARCH, Vol: 19, Pages: 149-152, ISSN: 0899-0220
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- Citations: 13
Wellmer A, Misra VP, Sharief MK, et al., 2001, A double-blind placebo-controlled clinical trial of recombinant human brain-derived neurotrophic factor (rhBDNF) in diabetic polyneuropathy, JOURNAL OF THE PERIPHERAL NERVOUS SYSTEM, Vol: 6, Pages: 204-210, ISSN: 1085-9489
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- Citations: 81
Facer P, Knowles CH, Tam PKH, et al., 2001, Novel capsaicin (VR1) and purinergic (P2X<sub>3</sub>) receptors in Hirschsprung's intestine, JOURNAL OF PEDIATRIC SURGERY, Vol: 36, Pages: 1679-1684, ISSN: 0022-3468
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- Citations: 39
Coppini DV, Wellmer A, Weng C, et al., 2001, The natural history of diabetic peripheral neuropathy determined by a 12 year prospective study using vibration perception thresholds, JOURNAL OF CLINICAL NEUROSCIENCE, Vol: 8, Pages: 520-524, ISSN: 0967-5868
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- Citations: 31
Yiangou YG, Facer P, Smith JAM, et al., 2001, Increased acid-sensing ion channel ASIC-3 in inflamed human intestine, EUROPEAN JOURNAL OF GASTROENTEROLOGY & HEPATOLOGY, Vol: 13, Pages: 891-896, ISSN: 0954-691X
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- Citations: 89
Yiangou Y, Facer P, Baecker PA, et al., 2001, ATP-gated ion channel P2X<sub>3</sub> is increased in human inflammatory bowel disease, NEUROGASTROENTEROLOGY AND MOTILITY, Vol: 13, Pages: 365-369, ISSN: 1350-1925
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- Citations: 103
Yiangou Y, Facer P, Ford A, et al., 2001, Capsaicin receptor VR1 and ATP-gated ion channel P2X<sub>3</sub> in human urinary bladder, BJU INTERNATIONAL, Vol: 87, Pages: 774-779, ISSN: 1464-4096
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- Citations: 126
Chan CLH, Yiangou Y, Facer P, et al., 2001, Increased capsaicin receptor VR1-immunoreactivity in acute inflammatory bowel disease, BRITISH JOURNAL OF SURGERY, Vol: 88, Pages: 10-10, ISSN: 0007-1323
Yiangou Y, Facer P, Dyer NHC, et al., 2001, Vanilloid receptor 1 immunoreactivity in inflamed human bowel, LANCET, Vol: 357, Pages: 1338-1339, ISSN: 0140-6736
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- Citations: 295
Facer P, Knowles CH, Thomas PK, et al., 2001, Decreased tyrosine kinase C expression may reflect developmental abnormalities in Hirschsprung's disease and idiopathic slow-transit constipation, BRITISH JOURNAL OF SURGERY, Vol: 88, Pages: 545-552, ISSN: 0007-1323
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- Citations: 13
Coward K, Aitken A, Powell A, et al., 2001, Plasticity of TTX-sensitive sodium channels PNI and brain III in injured human nerves, NEUROREPORT, Vol: 12, Pages: 495-500, ISSN: 0959-4965
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- Citations: 51
Coward K, Jowett A, Plumpton C, et al., 2001, Sodium channel β1 and β2 subunits parallel SNS/PN3 α-subunit changes in injured human sensory neurons, NEUROREPORT, Vol: 12, Pages: 483-488, ISSN: 0959-4965
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- Citations: 37
Pritchard J, Anand P, Broome J, et al., 2001, Double-blind randomized phase II study of hyperbaric oxygen in patients with radiation-induced brachial plexopathy, RADIOTHERAPY AND ONCOLOGY, Vol: 58, Pages: 279-286, ISSN: 0167-8140
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- Citations: 72
Shembalkar P, Anand P, Junaid I, et al., 2001, Neuropathic pain with vesical and rectal hyperreflexia and cocontraction after pelvic surgery, JOURNAL OF NEUROLOGY NEUROSURGERY AND PSYCHIATRY, Vol: 70, Pages: 410-411, ISSN: 0022-3050
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- Citations: 2
Coward K, Mosahebi A, Plumpton C, et al., 2001, Immunolocalisation of sodium channel NaG in the intact and injured human peripheral nervous system, JOURNAL OF ANATOMY, Vol: 198, Pages: 175-180, ISSN: 0021-8782
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- Citations: 5
Cheng W, Au DKK, Knowles CH, et al., 2001, Hirschsprung's disease: A more generalised neuropathy?, JOURNAL OF PEDIATRIC SURGERY, Vol: 36, Pages: 296-299, ISSN: 0022-3468
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- Citations: 4
Delany NS, Hurle M, Facer P, et al., 2001, Identification and characterization of a novel human vanilloid receptor-like protein, VRL-2, PHYSIOLOGICAL GENOMICS, Vol: 4, Pages: 165-174, ISSN: 1094-8341
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- Citations: 173
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