Publications
221 results found
Banati RB, Cagnin A, Brooks DJ, et al., 2001, Long-term trans-synaptic glial responses in the human thalamus after peripheral nerve injury, Neuroreport, Vol: 12, Pages: 3439-3442, ISSN: 0959-4965
Limb denervation leads to reorganization of the representational zones of the somatosensory cortex. Using [11C](R)-PK11195, a sensitive in vivo marker of glial cell activation, and PET, we provide first evidence that limb denervation induces a trans-synaptic increase in [11C](R)-PK11195 binding in the human thalamus but not somatosensory cortex: these brain structures appeared morphologically normal on magnetic resonance imaging (MRI). The increased thalamic signal was detectable many years after nerve injury, indicating persistent reorganization of the thalamus. This glial activation, beyond the first-order projection area of the injured neurons, may reflect continually altered afferent activity. Our findings support the view that long-term rearrangement of cortical representational maps is significantly determined within the thalamus.
Shembalkar PK, Till S, Boettger MK, et al., 2001, Increased sodium channel SNS/PN3 immunoreactivity in a causalgic finger, EUROPEAN JOURNAL OF PAIN, Vol: 5, Pages: 319-323, ISSN: 1090-3801
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- Citations: 16
Shembalkar P, Täubel J, Abadias M, et al., 2001, Cizolirtine citrate (E-4018) in the treatment of chronic neuropathic pain, CURRENT MEDICAL RESEARCH AND OPINION, Vol: 17, Pages: 262-266, ISSN: 0300-7995
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- Citations: 12
Saldanha G, Bär KJ, Yiangou Y, et al., 2000, Marked increase of interleukin-6 in injured human nerves and dorsal root ganglia, JOURNAL OF NEUROLOGY NEUROSURGERY AND PSYCHIATRY, Vol: 69, Pages: 693-694, ISSN: 0022-3050
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- Citations: 5
Carlstedt T, Anand P, Hallin R, et al., 2000, Spinal nerve root repair and reimplantation of avulsed ventral roots into the spinal cord after brachial plexus injury., J Neurosurg, Vol: 93, Pages: 237-247, ISSN: 0022-3085
OBJECT: The authors review the first series of 10 cases in which injured intraspinal brachial plexus were surgically repaired. They describe the technique of spinal cord implantation or repair of ruptured nerve roots, as well as patient outcome. METHODS: Spinal root repair/implantation was performed from 10 days to 9 months postinjury. There were nine male patients and one female patient. Postoperatively in most cases, regeneration of motor neurons from the spinal cord to denervated muscles could be demonstrated. The first signs of regeneration were noted approximately 9 to 12 months postoperatively. Useful function with muscle power of at least Medical Research Council Grade 3 occurred in three of 10 cases. Magnetic brain stimulation studies revealed a normal amplitude and latency from the cortex to reinnervated muscles on surgically treated and control sides. A certain degree of cocontraction between antagonistic muscles (for example, biceps-triceps) compromised function. With time there was a reduction of cocontractions, probably due to spinal cord plasticity. In these cases there was also, surprisingly, a return of sensory function, although the mechanism by which this occurred is uncertain. Sensory stimulation (thermal and mechanical) within the avulsed dermatomes was perceived abnormally and/or experienced at remote sites. There was some return of patients' sense of joint position. CONCLUSIONS: A short time lag between the accident and the surgery was recognized as a significant factor for a successful outcome. Reimplantation of avulsed nerve roots may be combined with other procedures such as nerve transfers in severe cases of brachial plexus injury.
Stanley SA, Todd JF, Small CJ, et al., 2000, The effects of ciliary neurotrophic factor on the hypothalamo-pituitary gonadal axis <i>in vitro</i> in female rats, JOURNAL OF NEUROENDOCRINOLOGY, Vol: 12, Pages: 1009-1013, ISSN: 0953-8194
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- Citations: 9
Yiangou Y, Facer P, Birch R, et al., 2000, P2X<sub>3</sub> receptor in injured human sensory neurons, NEUROREPORT, Vol: 11, Pages: 993-996, ISSN: 0959-4965
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- Citations: 37
Coward K, Plumpton C, Facer P, et al., 2000, Immunolocalization of SNS/PN3 and NaN/SNS2 sodium channels in human pain states, PAIN, Vol: 85, Pages: 41-50, ISSN: 0304-3959
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- Citations: 183
Facer P, Mann D, Mathur R, et al., 2000, Do nerve growth factor-related mechanisms contribute to loss of cutaneous nociception in leprosy?, PAIN, Vol: 85, Pages: 231-238, ISSN: 0304-3959
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- Citations: 40
Yiangou Y, Birch R, Sangameswaran L, et al., 2000, SNS/PN3 and SNS2/NaN sodium channel-like immunoreactivity in human adult and neonate injured sensory nerves, FEBS LETTERS, Vol: 467, Pages: 249-252, ISSN: 0014-5793
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- Citations: 49
Coward K, Saldanha G, Birch R, et al., 2000, SNS/PN3 and NaN/SNS2 sodium channel immunoreactivity in human pain states, 9th World Congress on Pain, Publisher: INT ASSOC STUDY PAIN (IASP) PRESS, Pages: 711-716
Facer P, Mann D, Terenghi G, et al., 1999, Nerve growth factor (NGF) concentrations in cultured human keratinocytes exposed to Mycobacterium leprae cell free extract., Lepr Rev, Vol: 70, Pages: 213-217, ISSN: 0305-7518
Knowles CH, Scott SM, Wellmer A, et al., 1999, Sensory and autonomic neuropathy in patients with idiopathic slow-transit constipation, BRITISH JOURNAL OF SURGERY, Vol: 86, Pages: 54-60, ISSN: 0007-1323
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- Citations: 45
Wellmer A, Sharief MK, Knowles CH, et al., 1999, Quantitative sensory and autonomic testing in male diabetic patients with erectile dysfunction, BJU INTERNATIONAL, Vol: 83, Pages: 66-70, ISSN: 1464-4096
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- Citations: 18
Knowles CH, Scott SM, Wellmer A, et al., 1998, Idiopathic slow-transit constipation: A sensory and autonomic neuropathy linked to Hirschsprung's disease., Publisher: W B SAUNDERS CO, Pages: A779-A779, ISSN: 0016-5085
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- Citations: 1
Terenghi G, Mann D, Kopelman PG, et al., 1997, trkA and trkC expression is increased in human diabetic skin., Neurosci Lett, Vol: 228, Pages: 33-36, ISSN: 0304-3940
Nerve growth factor (NGF) is reduced in epidermal keratinocytes in human diabetic skin, and this decrease has been related to dysfunction of cutaneous sensory fibres. In vitro studies show that keratinocytes express both NGF and its high-affinity receptor, trkA, and that NGF may increase keratinocyte proliferation and its own expression via an autocrine loop. However, the level of trkA expression in vivo by keratinocytes in normal and diabetic skin is unknown. We have therefore measured trkA expression in calf skin biopsies from patients with early subclinical diabetic neuropathy and control subjects, using in situ hybridisation combined with image analysis quantification. Expression of trkC was also studied, as its endogenous ligand neurotrophin-3 (NT-3) is related to NGF, and is present in human epidermis. Hybridisation signal was seen for both trkA and trkC localised throughout the epidermal layer of control skin, with a higher density of silver grain deposition observed for trkA mRNA. However, in diabetic epidermis there was a significant increase (P < 0.001) for both trk A (control, 0.178 +/- 0.013; diabetic, 0.304 +/- 0.032; mean silver grain counts/microm2 +/- SEM) and trkC expression (controls, 0.059 +/- 0.004; diabetics, 0.191 +/- 0.010). The up-regulation of epidermal trk receptors may result from decreased autocrine neurotrophin action, and could represent a compensatory mechanism.
ANAND P, WARNER G, PERRETT A, et al., 1994, A NEUROTROPHIC BASIS FOR DIFFERENTIAL SMALL FIBER DYSFUNCTION IN DIABETIC SENSORY AND AUTONOMIC POLYNEUROPATHY, ANNALS OF NEUROLOGY, Vol: 36, Pages: 284-285, ISSN: 0364-5134
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- Citations: 4
Ricketts D, Anand P, 1993, Sparing of deep rectal sensation after spinal cord injury., Injury, Vol: 24, ISSN: 0020-1383
ANAND P, GHATEI MA, CHRISTOFIDES ND, et al., 1991, DIFFERENTIAL NEUROPEPTIDE EXPRESSION AFTER VISCERAL AND SOMATIC NERVE INJURY IN THE CAT AND RAT, NEUROSCIENCE LETTERS, Vol: 128, Pages: 57-60, ISSN: 0304-3940
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- Citations: 16
ANAND P, SPRINGALL DR, BLANK MA, et al., 1991, NEUROPEPTIDES IN SKIN-DISEASE - INCREASED VIP IN ECZEMA AND PSORIASIS BUT NOT AXILLARY HYPERHIDROSIS, BRITISH JOURNAL OF DERMATOLOGY, Vol: 124, Pages: 547-549, ISSN: 0007-0963
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- Citations: 90
ANAND P, RUDGE P, MATHIAS CJ, et al., 1991, NEW AUTONOMIC AND SENSORY NEUROPATHY WITH LOSS OF ADRENERGIC SYMPATHETIC FUNCTION AND SENSORY NEUROPEPTIDES, LANCET, Vol: 337, Pages: 1253-1254, ISSN: 0140-6736
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- Citations: 23
ANAND P, GIBSON SJ, SCARAVILLI F, et al., 1990, STUDIES OF VASOACTIVE INTESTINAL POLYPEPTIDE EXPRESSION IN INJURED PERIPHERAL NEURONS USING CAPSAICIN, SYMPATHECTOMY AND MF MUTANT RATS, NEUROSCIENCE LETTERS, Vol: 118, Pages: 61-66, ISSN: 0304-3940
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- Citations: 13
MCMAHON SB, LEWIN GR, ANAND P, et al., 1989, QUANTITATIVE-ANALYSIS OF PEPTIDE LEVELS AND NEUROGENIC EXTRAVASATION FOLLOWING REGENERATION OF AFFERENTS TO APPROPRIATE AND INAPPROPRIATE TARGETS, NEUROSCIENCE, Vol: 33, Pages: 67-73, ISSN: 0306-4522
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- Citations: 42
Anand P, Llewelyn JG, Thomas PK, et al., 1988, Water content, vasoactive intestinal polypeptide and substance P in intact and crushed sciatic nerves of normal and streptozotocin-diabetic rats., J Neurol Sci, Vol: 83, Pages: 167-177, ISSN: 0022-510X
Observations on streptozotocin-diabetic rats have confirmed overhydration of peripheral nerve. As in previous studies, the sorbitol and fructose content, when expressed in terms of wet weight of nerve was found to be increased and myo-inositol decreased. The reduction in myo-inositol content was less, although still significant, when expressed in terms of protein content. Nerve water content increased during Wallerian degeneration following a crush injury in both normal and diabetic animals, but was relatively less in the latter. Vasoactive intestinal polypeptide (VIP) concentrations were significantly increased in diabetic nerve, those for substance P being normal. Both became severely reduced during Wallerian degeneration following nerve crush and ligature. The significance of these findings is discussed. The accumulation of water in the endoneurial compartment may be related to impaired extraction by the perineurium, to which the increased VIP content may contribute. These changes are unlikely to be responsible for nerve fibre damage.
ANAND P, BANNISTER R, MCGREGOR GP, et al., 1988, MARKED DEPLETION OF DORSAL SPINAL-CORD SUBSTANCE-P AND CALCITONIN GENE-RELATED PEPTIDE WITH INTACT SKIN FLARE RESPONSES IN MULTIPLE SYSTEM ATROPHY, JOURNAL OF NEUROLOGY NEUROSURGERY AND PSYCHIATRY, Vol: 51, Pages: 192-196, ISSN: 0022-3050
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- Citations: 8
ANAND P, MCGREGOR GP, GIBSON SJ, et al., 1987, INCREASE OF SUBSTANCE-P-LIKE IMMUNOREACTIVITY IN THE PERIPHERAL-NERVE OF THE AXOLOTL AFTER INJURY, NEUROSCIENCE LETTERS, Vol: 82, Pages: 241-245, ISSN: 0304-3940
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- Citations: 15
SENAPATI A, ANAND P, MCGREGOR GP, et al., 1986, DEPLETION OF NEUROPEPTIDES DURING WOUND-HEALING IN RAT SKIN, NEUROSCIENCE LETTERS, Vol: 71, Pages: 101-105, ISSN: 0304-3940
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- Citations: 38
ANAND P, MCGREGOR GP, GHATEI MA, et al., 1986, MARKED DEPLETION OF DORSAL SPINAL-CORD TACHYKININS AND CGRP WITH INTACT SKIN FLARES IN PATIENTS WITH THE SHY-DRAGER SYNDROME, REGULATORY PEPTIDES, Vol: 15, Pages: 165-165, ISSN: 0167-0115
SUZUKI H, GHATEI MA, REYNOLDS GP, et al., 1986, REGIONAL DISTRIBUTION OF A NOVEL PEPTIDE (P7 OF 1B236) IMMUNOREACTIVITY IN THE HUMAN CENTRAL-NERVOUS-SYSTEM, NEUROSCIENCE LETTERS, Vol: 67, Pages: 58-62, ISSN: 0304-3940
GIBSON SJ, POLAK JM, ANAND P, et al., 1986, A VIP/PHI-CONTAINING PATHWAY LINKS URINARY-BLADDER AND SACRAL SPINAL-CORD, PEPTIDES, Vol: 7, Pages: 205-219, ISSN: 0196-9781
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- Citations: 24
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