Publications
221 results found
Rage M, Van Acker N, Facer P, et al., 2010, The time course of CO<sub>2</sub> laser-evoked responses and of skin nerve fibre markers after topical capsaicin in human volunteers, CLINICAL NEUROPHYSIOLOGY, Vol: 121, Pages: 1256-1266, ISSN: 1388-2457
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- Citations: 63
Beneng K, Yilmaz Z, Yiangou Y, et al., 2010, Sensory purinergic receptor P2X<sub>3</sub> is elevated in burning mouth syndrome, INTERNATIONAL JOURNAL OF ORAL AND MAXILLOFACIAL SURGERY, Vol: 39, Pages: 815-819, ISSN: 0901-5027
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- Citations: 34
Cruccu G, Sommer C, Anand P, et al., 2010, EFNS guidelines on neuropathic pain assessment: revised 2009, EUROPEAN JOURNAL OF NEUROLOGY, Vol: 17, Pages: 1010-1018, ISSN: 1351-5101
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- Citations: 337
Beneng K, Renton T, Yilmaz Z, et al., 2010, Sodium channel Na<sub>v</sub>1.7 immunoreactivity in painful human dental pulp and burning mouth syndrome, BMC NEUROSCIENCE, Vol: 11, ISSN: 1471-2202
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- Citations: 19
Rage M, Van Acker N, Facer P, et al., 2010, Laser-evoked potentials and nerve markers in skin biopsies provide diagnostic and prognostic information regarding regenerating nerve fibres, 20th Meeting of the European-Neurological-Society, Publisher: SPRINGER HEIDELBERG, Pages: S182-S182, ISSN: 0340-5354
Mukerji G, Yiangou Y, Agarwal SK, et al., 2010, Increased Cannabinoid Receptor 1-Immunoreactive Nerve Fibers in Overactive and Painful Bladder Disorders and Their Correlation With Symptoms, UROLOGY, Vol: 75, ISSN: 0090-4295
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- Citations: 42
Akbar A, Yiangou Y, Facer P, et al., 2010, Expression of the TRPV1 receptor differs in quiescent inflammatory bowel disease with or without abdominal pain, GUT, Vol: 59, Pages: 767-774, ISSN: 0017-5749
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- Citations: 153
Roberts K, Papadaki A, McRobbie D, et al., 2010, A novel topical capsaicin model of "neuropathic pain" in human volunteers using cerebral evoked potentials and fMRI, United Kingdom Neuromuscular Translational Research Conference 2010, Publisher: PERGAMON-ELSEVIER SCIENCE LTD, Pages: S20-S20, ISSN: 0960-8966
Chambers JC, Zhao J, Terracciano CMN, et al., 2010, Genetic variation in <i>SCN10A</i> influences cardiac conduction, NATURE GENETICS, Vol: 42, Pages: 149-U80, ISSN: 1061-4036
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- Citations: 204
Mukerji GM, Yiangou Y, Agarwal SK, et al., 2010, Cannabinoid Receptor CB1 in overactive and painful bladder disorders and their correlation with symptoms, Annual Meeting of the British-Association-of-Urological-Surgeons, Publisher: WILEY-BLACKWELL PUBLISHING, INC, Pages: 22-23, ISSN: 1464-4096
Chambers J, Zhao J, Terracciano C, et al., 2009, Genetic Variation in SCN10a is Associated With Cardiac Conduction, Heart Block and Risk of Ventricular Fibrillation, 82nd Scientific Session of the American-Heart-Association, Publisher: LIPPINCOTT WILLIAMS & WILKINS, Pages: S579-S580, ISSN: 0009-7322
Sviderskaya EV, Easty DJ, Lawrence MA, et al., 2009, Functional neurons and melanocytes induced from immortal lines of postnatal neural crest-like stem cells, FASEB JOURNAL, Vol: 23, Pages: 3179-3192, ISSN: 0892-6638
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- Citations: 24
Anand P, Whiteside G, Fowler CJ, et al., 2009, Targeting CB<sub>2</sub> receptors and the endocannabinoid system for the treatment of pain, BRAIN RESEARCH REVIEWS, Vol: 60, Pages: 255-266, ISSN: 0165-0173
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- Citations: 160
Roberts KM, Shenoy R, Anand P, 2009, CONTACT HEAT EVOKED POTENTIALS (CHEPS) FOLLOWING TOPICAL CAPSAICIN: A MODEL OF "NEUROPATHIC PAIN'', Spring Scientific Meeting of the Association-of-British-Neurologists, Publisher: B M J PUBLISHING GROUP, Pages: 102-102, ISSN: 0022-3050
Roberts K, Papadaki A, Gonçalves C, et al., 2008, Contact heat evoked potentials using simultaneous EEG And fMRI and their correlation with evoked pain., BMC Anesthesiology, Vol: 8, Pages: 8-8, ISSN: 1471-2253
BACKGROUND: The Contact Heat Evoked Potential Stimulator (CHEPS) utilises rapidly delivered heat pulses with adjustable peak temperatures to stimulate the differential warm/heat thresholds of receptors expressed by Adelta and C fibres. The resulting evoked potentials can be recorded and measured, providing a useful clinical tool for the study of thermal and nociceptive pathways. Concurrent recording of contact heat evoked potentials using electroencephalogram (EEG) and functional magnetic resonance imaging (fMRI) has not previously been reported with CHEPS. Developing simultaneous EEG and fMRI with CHEPS is highly desirable, as it provides an opportunity to exploit the high temporal resolution of EEG and the high spatial resolution of fMRI to study the reaction of the human brain to thermal and nociceptive stimuli. METHODS: In this study we have recorded evoked potentials stimulated by 51° C contact heat pulses from CHEPS using EEG, under normal conditions (baseline), and during continuous and simultaneous acquisition of fMRI images in ten healthy volunteers, during two sessions. The pain evoked by CHEPS was recorded on a Visual Analogue Scale (VAS). RESULTS: Analysis of EEG data revealed that the latencies and amplitudes of evoked potentials recorded during continuous fMRI did not differ significantly from baseline recordings. fMRI results were consistent with previous thermal pain studies, and showed Blood Oxygen Level Dependent (BOLD) changes in the insula, post-central gyrus, supplementary motor area (SMA), middle cingulate cortex and pre-central gyrus. There was a significant positive correlation between the evoked potential amplitude (EEG) and the psychophysical perception of pain on the VAS. CONCLUSION: The results of this study demonstrate the feasibility of recording contact heat evoked potentials with EEG during continuous and simultaneous fMRI. The combined use of the two methods can lead to identification of distinct patterns of brain activity indica
Anand U, Otto WR, Sanchez-Herrera D, et al., 2008, Cannabinoid receptor CB2 localisation and agonist-mediated inhibition of capsaicin responses in human sensory neurons, PAIN, Vol: 138, Pages: 667-680, ISSN: 0304-3959
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- Citations: 125
Sánchez D, Johnson N, Li C, et al., 2008, Noncontact measurement of the local mechanical properties of living cells using pressure applied via a pipette., Biophysical journal, Vol: 95, Pages: 3017-27, ISSN: 1542-0086
Mechanosensitivity in living biological tissue is a study area of increasing importance, but investigative tools are often inadequate. We have developed a noncontact nanoscale method to apply quantified positive and negative force at defined positions to the soft responsive surface of living cells. The method uses applied hydrostatic pressure (0.1-150 kPa) through a pipette, while the pipette-sample separation is kept constant above the cell surface using ion conductance based distance feedback. This prevents any surface contact, or contamination of the pipette, allowing repeated measurements. We show that we can probe the local mechanical properties of living cells using increasing pressure, and hence measure the nanomechanical properties of the cell membrane and the underlying cytoskeleton in a variety of cells (erythrocytes, epithelium, cardiomyocytes and neurons). Because the cell surface can first be imaged without pressure, it is possible to relate the mechanical properties to the local cell topography. This method is well suited to probe the nanomechanical properties and mechanosensitivity of living cells.
Anand U, Otto WR, Bountra C, et al., 2008, Cytosine arabinoside affects the heat and capsaicin receptor TRPV1 localisation and sensitivity in human sensory neurons, JOURNAL OF NEURO-ONCOLOGY, Vol: 89, Pages: 1-7, ISSN: 0167-594X
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- Citations: 14
Anand U, Otto WR, Facer P, et al., 2008, TRPA1 receptor localisation in the human peripheral nervous system and functional studies in cultured human and rat sensory neurons, NEUROSCIENCE LETTERS, Vol: 438, Pages: 221-227, ISSN: 0304-3940
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- Citations: 134
Atherton DD, Taherzadeh O, Elliot D, et al., 2008, Age-dependent development of chronic neuropathic pain, allodynia and sensory recovery after upper limb nerve injury in children, JOURNAL OF HAND SURGERY-EUROPEAN VOLUME, Vol: 33E, Pages: 186-191, ISSN: 1753-1934
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- Citations: 24
Gooneratne ML, Facer P, Knowles CH, et al., 2008, Normalization of substance P levels in rectal mucosa of patients with faecal incontinence treated successfully by sacral nerve stimulation, Meeting of the Association-of-Coloproctology-of-Great-Britain-and-Ireland, Publisher: JOHN WILEY & SONS LTD, Pages: 477-483, ISSN: 0007-1323
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- Citations: 26
Keh SM, Facer P, Simpson KD, et al., 2008, Increased Nerve Fiber Expression of Sensory Sodium Channels Nav1.7, Nav1.8, and Nav1.9 in Rhinitis, LARYNGOSCOPE, Vol: 118, Pages: 573-579, ISSN: 0023-852X
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- Citations: 22
Shenoy R, Yiangou Y, Misra VP, et al., 2008, Marked abnormalities of sensory nerve fibres expressing heat and cool receptors TRPV1 and TRPM8 in complex regional pain syndrome, Annual Meeting of the Association-of-British-Neurologists, Publisher: B M J PUBLISHING GROUP, Pages: 359-359, ISSN: 0022-3050
Narayanaswamy H, Roberts K, Anand P, 2008, Use of the novel Contact Heat Evoked Potential Stimulator (CHEPS) for the diagnosis of small fibre neuropathy: 75 patients, Publisher: WILEY, ISSN: 0742-3071
Tingaker BK, Ekman-Ordeberg G, Facer P, et al., 2008, Influence of pregnancy and labor on the occurrence of nerve fibers expressing the capsaicin receptor TRPVI in human corpus and cervix uteri, Reproductive Biology and Endocrinology, Vol: 6, Pages: 1-8, ISSN: 1477-7827
BackgroundCervical ripening is a prerequisite for a normal obstetrical outcome. This process, including labor, is a painful event that shares features with inflammatory reactions where peripheral nociceptive pathways are involved. The capsaicin and heat receptor TRPV1 is a key molecule in sensory nerves involved in peripheral nociception, but little is known regarding its role in the pregnant uterus. Therefore, the aim of this study was to investigate human corpus and cervix uteri during pregnancy and labor and non-pregnant controls for the presence of TRPV1.MethodsWe have investigated human uterine corpus and cervix biopsies at term pregnancy and parturition. Biopsies were taken from the upper edge of the hysterotomy during caesarean section at term (n = 8), in labor (n = 8) and from the corresponding area in the non-pregnant uterus after hysterectomy (n = 8). Cervical biopsies were obtained transvaginally from the anterior cervical lip. Serial frozen sections were examined immunohistochemically using specific antibodies to TRPV1 and nerve markers (neurofilaments/peripherin).ResultsIn cervix uteri, TRPV1-immunoreactive fibers were scattered throughout the stroma and around blood vessels, and appeared more frequent in the sub-epithelium. Counts of TRPV1-immunoreactive nerve fibers were not significantly different between the three groups. In contrast, few TRPV1-immunoreactive fibers were found in nerve fascicles in the non-pregnant corpus, and none in the pregnant corpus.ConclusionIn this study, TRPV1 innervation in human uterus during pregnancy and labor is shown for the first time. During pregnancy and labor there was an almost complete disappearance of TRPV1 positive nerve fibers in the corpus. However, cervical innervation remained throughout pregnancy and labor. The difference in TRPV1 innervation between the corpus and the cervix is thus very marked. Our data suggest that TRPV1 may be involved in pain mechanisms associated with cervical ripening and labor. Fur
Akbar A, Yiangou Y, Facer P, et al., 2008, Increased capsaicin receptor TRPV1-expressing sensory fibres in irritable bowel syndrome and their correlation with abdominal pain, Gut, Vol: 57, Pages: 923-929, ISSN: 0017-5749
Objective: The capsaicin receptor TRPV1 (transient receptor potential vanilloid type-1) may play an important role in visceral pain and hypersensitivity states. In irritable bowel syndrome (IBS), abdominal pain is a common and distressing symptom where the pathophysiology is still not clearly defined. TRPV1-immunoreactive nerve fibres were investigated in colonic biopsies from patients with IBS, and this was related to abdominal pain.Methods: Rectosigmoid biopsies were collected from 23 IBS patients fulfilling Rome II criteria, and from 22 controls. Abdominal pain scores were recorded using a validated questionnaire. TRPV1-, substance P- and neuronal marker protein gene product (PGP) 9.5-expressing nerve fibres, mast cells (c-kit) and lymphocytes (CD3 and CD4) were quantified, following immunohistochemistry with specific antibodies. The biopsy findings were related to the abdominal pain scores.Results: A significant 3.5-fold increase in median numbers of TRPV1-immunoreactive fibres was found in biopsies from IBS patients compared with controls (p<0.0001). Substance P-immunoreactive fibres (p = 0.01), total nerve fibres (PGP9.5) (p = 0.002), mast cells (c-kit) (p = 0.02) and lymphocytes (CD3) (p = 0.03) were also significantly increased in the IBS group. In multivariate regression analysis, only TRPV1-immuno-reactive fibres (p = 0.005) and mast cells (p = 0.008) were significantly related to the abdominal pain score.Conclusions: Increased TRPV1 nerve fibres are observed in IBS, together with a low-grade inflammatory response. The increased TRPV1 nerve fibres may contribute to visceral hypersensitivity and pain in IBS, and provide a novel therapeutic target.
De Beule PAA, Dunsby C, Galletly NP, et al., 2007, A hyperspectral fluorescence lifetime probe for skin cancer diagnosis, REVIEW OF SCIENTIFIC INSTRUMENTS, Vol: 78, ISSN: 0034-6748
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- Citations: 70
Inglis JJ, Notley CA, Essex D, et al., 2007, Collagen-induced arthritis as a model of hyperalgesia, ARTHRITIS AND RHEUMATISM, Vol: 56, Pages: 4015-4023, ISSN: 0004-3591
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- Citations: 141
Scheiermann C, Meda P, Aurrand-Lions M, et al., 2007, Expression and function of junctional adhesion molecule-C in myelinated peripheral nerves, SCIENCE, Vol: 318, Pages: 1472-1475, ISSN: 0036-8075
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- Citations: 49
Yiangou Y, Facer P, Lain PC, et al., 2007, Voltage-gated ion channel Na<sub>v</sub> 1.7 innervation in patients with idiopathic rectal hypersensitivity and paroxysmal extreme pain disorder (familial rectal pain), NEUROSCIENCE LETTERS, Vol: 427, Pages: 77-82, ISSN: 0304-3940
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- Citations: 32
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