Imperial College London
Alternate

ProfessorPraveenAnand

Faculty of Medicine, Department of Brain Sciences

Professor
 
 
 
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Contact

 

+44 (0)20 3313 3319p.anand

 
 
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Location

 

Area A Grd FloorUnknownHammersmith Campus

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Summary

 

Publications

Citation

BibTex format

@article{Granovsky:2016:10.1097/j.pain.0000000000000495,
author = {Granovsky, Y and Anand, P and Nakae, A and Nascimento, O and Smith, B and Sprecher, E and Valls-Sole, J},
doi = {10.1097/j.pain.0000000000000495},
journal = {Pain},
pages = {1156--1163},
title = {Normative data for A delta contact heat evoked potentials in adult population: a multicenter study},
url = {http://dx.doi.org/10.1097/j.pain.0000000000000495},
volume = {157},
year = {2016}
}
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RIS format (EndNote, RefMan)

TY  - JOUR
AB  - There has been a significant increase over recent years in the use of contact heat evoked potentials (CHEPs) for the evaluation of small nerve fiber function. Measuring CHEP amplitude and latency has clinical utility for the diagnosis and assessment of conditions with neuropathic pain. This international multicenter study aimed to provide reference values for CHEPs to stimuli at 5 commonly examined body sites. Contact heat evoked potentials were recorded from 226 subjects (114 females), distributed per age decade between 20 and 79 years. Temperature stimuli were delivered by a thermode (32°C-51°C at a rate of 70°C/s). In phase I of the study, we investigated side-to-side differences and reported the maximum normal side-to-side difference in A[delta] CHEP peak latency and amplitude for leg, forearm, and face. In phase II, we obtained normative data for 3 CHEP parameters (N2P2 amplitude, N2 latency, and P2 latency), stratified for gender and age decades from face, upper and lower limbs, and overlying cervical and lumbar spine. In general, larger CHEP amplitudes were associated with higher evoked pain scores. Females had CHEPs of larger amplitude and shorter latency than males. This substantive data set of normative values will facilitate the clinical use of CHEPs as a rapid, noninvasive, and objective technique for the assessment of patients presenting with neuropathic pain.
AU  - Granovsky,Y
AU  - Anand,P
AU  - Nakae,A
AU  - Nascimento,O
AU  - Smith,B
AU  - Sprecher,E
AU  - Valls-Sole,J
DO  - 10.1097/j.pain.0000000000000495
EP  - 1163
PY  - 2016///
SN  - 0304-3959
SP  - 1156
TI  - Normative data for A delta contact heat evoked potentials in adult population: a multicenter study
T2  - Pain
UR  - http://dx.doi.org/10.1097/j.pain.0000000000000495
VL  - 157
ER  -
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