Publications
21 results found
Aboagye E, Islam S, Inglese M, et al., 2023, Feasibility of [18F]fluoropivalate hybrid PET/MRI for imaging lower and higher grade glioma: a prospective first-in-patient pilot study, European Journal of Nuclear Medicine and Molecular Imaging, Vol: 50, Pages: 3982-3995, ISSN: 0340-6997
Purpose:MRI and PET are used in neuro-oncology for the detection and characterisation of lesions for malignancy to target surgical biopsy and to plan surgical resections or stereotactic radiosurgery. The critical role of short-chain fatty acids (SCFAs) in brain tumour biology has come to the forefront. The non-metabolised SCFA radiotracer, [18F]fluoropivalate (FPIA), shows low background signal in most tissues except eliminating organs and has appropriate human dosimetry. Tumour uptake of the radiotracer is, however, unknown. We investigated the uptake characteristics of FPIA in this pilot PET/MRI study.Methods:Ten adult glioma subjects were identified based on radiological features using standard-of-care MRI prior to any surgical intervention, with subsequent histopathological confirmation of glioma subtype and grade (lower-grade – LGG – and higher-grade – HGG – patients). FPIA was injected as an intravenous bolus injection (range 342–368 MBq), and dynamic PET and MRI data were acquired simultaneously over 66 min.Results:All patients tolerated the PET/MRI protocol. Three patients were reclassified following resection and histology. Tumour maximum standardised uptake value (SUVmax,60) increased in the order LGG (WHO grade 2) < HGG (WHO grade 3) < HGG (WHO grade 4). The net irreversible solute transfer, Ki, and influx rate constant, K1, were significantly higher in HGG (p < 0.05). Of the MRI variables studied, DCE-MRI-derived extravascular-and-extracellular volume fraction (ve) was high in tumours of WHO grade 4 compared with other grades (p < 0.05). SLC25A20 protein expression was higher in HGG compared with LGG.Conclusion:Tumoural FPIA PET uptake is higher in HGG compared to LGG. This study supports further investigation of FPIA PET/MRI for brain tumour imaging in a larger patient population.
Aboagye E, Aravind P, Popat S, et al., 2023, A subset of non-small cell lung cancer patients treated with pemetrexed show 18f-fluorothymidine ‘flare’ on positron emission tomography, Cancers, Vol: 15, Pages: 1-14, ISSN: 2072-6694
Thymidylate synthase (TS) remains a major target for cancer therapy. TS inhibition elicits increases in DNA salvage pathway activity, detected as a transient compensatory “flare” in 3′-deoxy-3′-[18F]fluorothymidine positron emission tomography (18F-FLT PET). We determined the magnitude of the 18F-FLT flare in non-small cell lung cancer (NSCLC) patients treated with the antifolate pemetrexed in relation to clinical outcome. Method: Twenty-one patients with advanced/metastatic non-small cell lung cancer (NSCLC) scheduled to receive palliative pemetrexed ± platinum-based chemotherapy underwent 18F-FLT PET at baseline and 4 h after initiating single-agent pemetrexed. Plasma deoxyuridine (dUrd) levels and thymidine kinase 1 (TK1) activity were measured before each scan. Patients were then treated with the combination therapy. The 18F-FLT PET variables were compared to RECIST 1.1 and overall survival (OS). Results: Nineteen patients had evaluable PET scans at both time points. A total of 32% (6/19) of patients showed 18F-FLT flares (>20% change in SUVmax-wsum). At the lesion level, only one patient had an FLT flare in all the lesions above (test–retest borders). The remaining had varied uptake. An 18F-FLT flare occurred in all lesions in 1 patient, while another patient had an 18F-FLT reduction in all lesions; 17 patients showed varied lesion uptake. All patients showed global TS inhibition reflected in plasma dUrd levels (p < 0.001) and 18F-FLT flares of TS-responsive normal tissues including small bowel and bone marrow (p = 0.004 each). Notably, 83% (5/6) of patients who exhibited 18F-FLT flares were also RECIST responders with a median OS of 31 m, unlike patients who did not exhibit 18F-FLT flares (15 m). Baseline plasma TK1 was prognostic of survival but its activity remained unchanged following treatment. Conclusions: The better radiological response and longer survival observed in patients with an 18F-FLT flare suggest the
Islam S, Inglese M, Aravind P, et al., 2022, 18F-Fluoropivalate PET/MRI: imaging of treatment naive patients and patients treated with radiosurgery, 34th EORTC-NCI-AACR Symposium on Molecular Targets and Cancer Therapeutics, Publisher: Elsevier, Pages: S49-S49, ISSN: 0959-8049
Kenny LM, Gilbert FJ, Gopalakrishnan G, et al., 2022, The HERPET study: Imaging HER2 expression in breast cancer with the novel PET tracer [<SUP>18</SUP>F]GE-226, a first-in-patient study., Annual Meeting of the American-Society-of-Clinical-Oncology (ASCO), Publisher: LIPPINCOTT WILLIAMS & WILKINS, ISSN: 0732-183X
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- Citations: 1
Aravind P, Popat S, Barwick TD, et al., 2022, [F-18]Fluorothymidine(FLT)-PET imaging of thymidine kinase 1 pharmacodynamics in non-small cell lung cancer treated with pemetrexed., ASCO, Publisher: LIPPINCOTT WILLIAMS & WILKINS, ISSN: 0732-183X
Maher G, Fisher RA, Kaur B, et al., 2022, Sensitive screening of single nucleotide polymorphisms in cell free DNA for diagnosis of gestational tumours, npj Genomic Medicine, Vol: 7, Pages: 1-8, ISSN: 2056-7944
Tumours expressing human chorionic gonadotropin (hCG), the majority of which are difficult to biopsy due to their vascularity, have disparate prognoses depending on their origin. As optimal management relies on accurate diagnosis, we aimed to develop a sensitive cell free DNA (cfDNA) assay to non-invasively distinguish between cases of gestational and non-gestational origin. Deep error-corrected Illumina sequencing of 195 common single nucleotide polymorphisms (SNPs) in cfDNA and matched genomic DNA from 36 patients with hCG-secreting tumours (serum hCG 5 to 3,042,881 IU/L) and 7 controls with normal hCG levels (≤ 4 IU/L) was performed. cfDNA from confirmed gestational tumours with hCG levels ranging from 1,497 to 700,855 IU/L had multiple (n ≥12) ‘non-host’ alleles (i.e. alleles of paternal origin). In such cases the non-host fraction of cfDNA ranged from 0.3% - 40.4% and correlated with serum hCG levels. At lower hCG levels the ability to detect non-host cfDNA was variable, with the detection limit dependent on the type of causative pregnancy. Patients with non-gestational tumours were identifiable by the absence of non-host cfDNA, with copy number alterations detectable in the majority of cases. Following validation in a larger cohort, our sensitive assay will enable clinicians to better inform patients, for whom biopsy is inappropriate, of their prognosis and provide optimum management.
Maher GJ, Fisher RA, Kaur B, et al., 2022, Sensitive screening of cell free DNA to determine the origin of trophoblastic tumours, Publisher: SPRINGERNATURE, Pages: 97-98, ISSN: 1018-4813
Aravind P, Krishnan PU, Srinivasa H, et al., 2020, Screening of Burns Unit Staff of a Tertiary Care Hospital for Methicillin-Resistant Staphylococcus Aureus Colonisation, McGill Journal of Medicine, Vol: 5
<jats:p>Staphylococcus aureus is a significant nosocomial pathogen and the development of resistance to methicillin poses a major threat to its control. This study was conducted over a three month period in a Burns Unit of a tertiary care hospital to determine the prevalance of methicillin- resistant S. aureus (MRSA) colonisation in health care workers. All health care workers were screened using swabs from the hairline, nostril, axilla, and hands. Seventeen of 34 health care workers screened were MRSA-positive; 16 people tested positive for the methicillin-sensitive strain of S. aureus, 7 of whom were also MRSA-positive at a different site. In total, over two thirds of all health care workers were colonised by S. aureus. Pus samples from patients admitted in the same unit over the three month study period were analysed and showed that 21% of patients were infected or colonised with MRSA. Although a direct causal relationship is not established by these data, it is reasonable to assume that transmission from colonised health care workers is responsible, at least in part, for the extent of infection/colonisation among patients. These findings identify the need for a well defined policy for screening health care workers and controlling the rates of colonisation with potentially dangerous pathogens given the risk of transmission to susceptible patients.</jats:p>
Aravind P, Jingree C, Castell F, et al., 2017, Long-term Outcome of HER2-positive Early Breast Cancer Patients in the Trastuzumab Era: a Single Centre Experience, Publisher: ELSEVIER SCIENCE LONDON, Pages: E97-E97, ISSN: 0936-6555
Aravind P, Rigg A, Castell F, 2017, Upper Limb Venous Thromboembolism in Early Breast Cancer Patients on Chemotherapy: a Single Centre Experience, Publisher: ELSEVIER SCIENCE LONDON, Pages: E97-E97, ISSN: 0936-6555
Pinato D, Pria AD, Aravind P, et al., 2017, HIV-associated hepatocellular carcinoma: validation of the albumin-bilirubin (ALBI) grade as a prognostic indicator in 387 patients, BHIVA, Publisher: WILEY, Pages: 39-39, ISSN: 1464-2662
Choy J, Haq I, Pria AD, et al., 2017, Plasma Epstein-Barr virus DNA does not predict outcome in advanced HIV-associated Hodgkin lymphoma, Publisher: WILEY, Pages: 9-10, ISSN: 1464-2662
Aravind P, Jingree C, Castell F, et al., 2017, Long term outcome of HER2-positive early breast cancer patients in the trastuzumab era: a single centre experience
Aravind P, Rigg A, Castell F, 2017, Upper limb venous thromboembolism in early breast cancer patients on chemotherapy: a single centre experience, Publisher: CHURCHILL LIVINGSTONE, Pages: S22-S22, ISSN: 0960-9776
Aravind P, Thillai K, Suddle A, et al., 2017, Application of ALBI and PALBI score as prognostic variables in hepatocellular carcinoma patients treated with transarterial-chemoembolization., 53rd Annual Clinical Meeting of the American-Society-of-Clinical-Oncology (ASCO)
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Aravind P, Thillai K, Suddel A, et al., 2016, P-098 Prognostic significance of comorbidities in elderly patients with Hepatocellular carcinoma (HCC) treated with Transarterial Chemoembolization: a Single Centre Experience
Aravind P, Thillai K, Suddel A, et al., 2016, Prognostic significance of comorbidities in elderly patients with Hepatocellular carcinoma (HCC) treated with Transarterial Chemoembolization: a Single Centre Experience, 18th World Congress of the European-Society-for-Medical-Oncology (ESMO) on Gastrointestinal Cancer, Publisher: OXFORD UNIV PRESS, Pages: 29-29, ISSN: 0923-7534
Aravind P, Thillai K, Heaton N, et al., 2016, A single centre experience of the prognostic variables in hepatocellular carcinoma (HCC) patients treated with transarterial chemoembolization, 18th World Congress of the European-Society-for-Medical-Oncology (ESMO) on Gastrointestinal Cancer, Publisher: OXFORD UNIV PRESS, Pages: 109-109, ISSN: 0923-7534
Aravind P, Thillai K, Sarker D, et al., 2016, Prognostic significance of the hepatoma arterial embolization prognostic (HAP) score in hepatocellular carcinoma (HCC) patients treated with transarterial chemoembolization: A single centre experience., Annual Meeting of the American-Society-of-Clinical-Oncology (ASCO), Publisher: AMER SOC CLINICAL ONCOLOGY, ISSN: 0732-183X
Oikonomopoulos G, Aravind P, Sarker D, 2016, Lenvatinib: a potential breakthrough in advanced hepatocellular carcinoma?, FUTURE ONCOLOGY, Vol: 12, Pages: 465-476, ISSN: 1479-6694
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- Citations: 19
Shobha V, Prakash R, Arvind P, et al., 2014, Histopathology of lupus nephritis: A single-center, cross-sectional study from Karnataka, India, Internet Journal of Rheumatology and Clinical Immunology, Vol: 2
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