Imperial College London
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ProfessorPaulAylin

Faculty of Medicine, School of Public Health

Professor of Epidemiology and Public Health
 
 
 
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Contact

 

p.aylin Website

 
 
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Location

 

Reynolds BuildingCharing Cross Campus

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Summary

 

Publications

Citation

BibTex format

@techreport{Perez:2020:10.25561/78613,
author = {Perez, Guzman PN and Daunt, A and Mukherjee, S and Crook, P and Forlano, R and Kont, M and Lochen, A and Vollmer, M and Middleton, P and Judge, R and Harlow, C and Soubieres, A and Cooke, G and White, P and Hallett, T and Aylin, P and Ferguson, N and Hauck, K and Thursz, M and Nayagam, AS},
doi = {10.25561/78613},
title = {Report 17: Clinical characteristics and predictors of outcomes of hospitalised patients with COVID-19 in a London NHS Trust: a retrospective cohort study},
url = {http://dx.doi.org/10.25561/78613},
year = {2020}
}
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RIS format (EndNote, RefMan)

TY  - RPRT
AB  - Clinical characteristics and determinants of outcomes for hospitalised COVID-19 patients in the UK remain largely undescribed and emerging evidence suggests ethnic minorities might be disproportionately affected. We describe the characteristics and outcomes of patients hospitalised for COVID-19 in three large London hospitals with a multi-ethnic catchment population.We performed a retrospective cohort study on all patients hospitalised with laboratory-confirmed SARS-CoV-2 infection at Imperial College Healthcare NHS Trust between February 25 and April 5, 2020. Outcomes were recorded as of April 19, 2020. Logistic regression models, survival analyses and cumulative competing risk analyses were performed to evaluate factors associated with COVID-19 hospital mortality.Of 520 patients in this cohort (median age 67 years, (IQR 26) and 62% male), 302 (68%) had been discharged alive, 144 (32%) died and 74 (14%) were still hospitalised at the time of censoring. Increasing age (adjusted odds ratio [aOR] 2·16, 95%CI 1·50-3·12), severe hypoxia (aOR 3·75, 95%CI 1·80-7·80), low platelets (aOR 0·65, 95%CI 0.49·0·85), reduced estimated glomerular filtration rate (aOR 4·11, 95%CI 1·58-10·69), bilirubin >21mmol/L (aOR 2·32, 95%CI 1·05-5·14) and low albumin (aOR 0·77, 9%%CI 0·59-1·01) were associated with increased risk of in-hospital mortality. Individual comorbidities were not independently associated with risk of death. Regarding ethnicity, 209 (40%) were from a black and Asian minority, for 115 (22%) ethnicity was unknown and 196 (38%) patients were white. Compared to the latter, black patients were significantly younger and had less comorbidities. Whilst the crude OR of death of black compared to white patients was not significant (1·14, 95%CI 0·69-1·88, p=0.62), adjusting for age and comorbidity showed a trend towards significance
AU  - Perez,Guzman PN
AU  - Daunt,A
AU  - Mukherjee,S
AU  - Crook,P
AU  - Forlano,R
AU  - Kont,M
AU  - Lochen,A
AU  - Vollmer,M
AU  - Middleton,P
AU  - Judge,R
AU  - Harlow,C
AU  - Soubieres,A
AU  - Cooke,G
AU  - White,P
AU  - Hallett,T
AU  - Aylin,P
AU  - Ferguson,N
AU  - Hauck,K
AU  - Thursz,M
AU  - Nayagam,AS
DO  - 10.25561/78613
PY  - 2020///
TI  - Report 17: Clinical characteristics and predictors of outcomes of hospitalised patients with COVID-19 in a London NHS Trust: a retrospective cohort study
UR  - http://dx.doi.org/10.25561/78613
UR  - https://www.imperial.ac.uk/media/imperial-college/medicine/mrc-gida/2020-04-29-COVID19-Report-17.pdf
UR  - http://hdl.handle.net/10044/1/78613
ER  -
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