Imperial College London
Portrait Picture

ProfessorPaulAylin

Faculty of Medicine, School of Public Health

Professor of Epidemiology and Public Health
 
 
 
//

Contact

 

p.aylin Website

 
 
//

Location

 

Reynolds BuildingCharing Cross Campus

//

Summary

 

Publications

Citation

BibTex format

@article{Zhu:2021:rs.3.rs-690499/v1,
author = {Zhu, NJ and Rawson, TM and Mookerjee, S and Price, JR and Davies, F and Otter, J and Aylin, P and Hope, R and Gilchrist, M and Shersing, Y and Holmes, A},
doi = {rs.3.rs-690499/v1},
title = {Changing patterns of bloodstream infections in the community and in acute care across two COVID-19 epidemic waves: a retrospective analysis},
url = {http://dx.doi.org/10.21203/rs.3.rs-690499/v1},
year = {2021}
}
Download

RIS format (EndNote, RefMan)

TY  - JOUR
AB  - <jats:title>Abstract</jats:title>        <jats:p><jats:bold>Introduction </jats:bold>We examined the epidemiology of community- and hospital-acquired bloodstream infections (BSIs) in COVID-19 and non-COVID-19 patients across two epidemic waves. <jats:bold>Methods </jats:bold>We analysed blood cultures, SARS-CoV-2 tests, and hospital episodes of patients presenting and admitted to a London hospital group between January 2020 and February 2021. We reported BSI incidence, as well as changes in sampling, case mix, bed and staff capacity, and COVID-19 variants. <jats:bold>Results </jats:bold>34,044 blood cultures were taken. We identified 1,047 BSIs; 653 (62.4%) defined epidemiologically as community-acquired and 394 (37.6%) as hospital-acquired. BSI rates and community / hospital ratio were similar to those pre-pandemic. However, important changes in patterns were seen. Among community-acquired BSIs, <jats:italic>Escherichia coli</jats:italic> BSIs remained lower than pre-pandemic level during the two COVID-19 waves, however peaked following lockdown easing in May 2020, deviating from the historical trend of peaking in August. The hospital-acquired BSI rate was 100.4 per 100,000 patient-days across the pandemic, increasing to 132.3 during the first COVID-19 wave and 190.9 during the second, with significant increase seen in elective non-COVID-19 inpatients. Patients who developed a hospital-acquired BSI, including those without COVID-19, experienced 20.2 excess days of hospital stay and 26.7% higher mortality, higher than reported in pre-pandemic literature. In intensive care units (ICUs), the overall BSI rate was 311.8 per 100,000 patient-ICU days, increasing to 421.0 during the second wave, compared to 101.3 pre-COVID. The BSI incidence in those infected with the SARS-CoV-2 Alpha variant was similar to that seen with earlier variants. <jats:bold>Conclusion </jats:bold>The pandemic and nation
AU  - Zhu,NJ
AU  - Rawson,TM
AU  - Mookerjee,S
AU  - Price,JR
AU  - Davies,F
AU  - Otter,J
AU  - Aylin,P
AU  - Hope,R
AU  - Gilchrist,M
AU  - Shersing,Y
AU  - Holmes,A
DO  - rs.3.rs-690499/v1
PY  - 2021///
TI  - Changing patterns of bloodstream infections in the community and in acute care across two COVID-19 epidemic waves: a retrospective analysis
UR  - http://dx.doi.org/10.21203/rs.3.rs-690499/v1
ER  -
Download