Imperial College London
Alternate

Dr P Boon Lim

Faculty of Medicine, National Heart & Lung Institute

Honorary Clinical Senior Lecturer
 
 
 
//

Contact

 

+44 (0)20 3313 2115p.b.lim Website

 
 
//

Location

 

Cardiology DepartmentBlock B Hammersmith HospitalHammersmith Campus

//

Summary

 

Publications

Citation

BibTex format

@article{Malcolme-Lawes:2016:10.1016/j.autneu.2016.08.007,
author = {Malcolme-Lawes, L and Sandler, BC and Sikkel, MB and Lim, PB and Kanagaratnam, P},
doi = {10.1016/j.autneu.2016.08.007},
journal = {Autonomic Neuroscience},
pages = {80--87},
title = {Ablation therapy for left atrial autonomic modification.},
url = {http://dx.doi.org/10.1016/j.autneu.2016.08.007},
volume = {199},
year = {2016}
}
Download

RIS format (EndNote, RefMan)

TY  - JOUR
AB  - The autonomic nervous system is implicated in the multifactorial pathogenesis of atrial fibrillation (AF) but few studies have attempted neural targeting for therapeutic intervention. We have demonstrated that short bursts of stimulation, at specific sites of left atrial ganglionated plexi (GPs), trigger fibrillation-inducing atrial ectopy and importantly continuous stimulation of these sites may not induce AV block, the 'conventional' marker used to locate GPs. We have shown that these ectopy-triggering GP (ET-GP) sites are anatomically stable and can be rendered inactive by either ablation at the site or by ablation between the site and the adjacent pulmonary vein (PV). This may have important implications for planning patient specific strategies for ablation of paroxysmal AF in the future.
AU  - Malcolme-Lawes,L
AU  - Sandler,BC
AU  - Sikkel,MB
AU  - Lim,PB
AU  - Kanagaratnam,P
DO  - 10.1016/j.autneu.2016.08.007
EP  - 87
PY  - 2016///
SN  - 1566-0702
SP  - 80
TI  - Ablation therapy for left atrial autonomic modification.
T2  - Autonomic Neuroscience
UR  - http://dx.doi.org/10.1016/j.autneu.2016.08.007
VL  - 199
ER  -
Download