Imperial College London


Faculty of MedicineNational Heart & Lung Institute

Honorary Senior Research Fellow



+44 (0)20 7351 8140p.barton Website




2054Sydney StreetRoyal Brompton Campus





Paul is Honorary Senior Research Fellow at the National Heart and Lung Institute and Research Manager for the Cardiovascular Genetics and Genomics Group ( He has particular interests in the genetics of Inherited Cardiac Conditions, gene-environment interactions, the role of non-coding RNA and in enhancing international collaboration - currently with research partners based in Florence, Madrid and the Aswan Heart Centre in Egypt.

Paul studied for a PhD in human genetics at the University of London and undertook postdoctoral training in Margaret Buckingham's laboratory at the Pasteur Institute, Paris - initially supported by fellowships from the Muscular Dystrophy Association of America (MDA) and European Molecular Biology Organization (EMBO) and later continuing as a tenured staff scientist (CR1) of the French Institut National de la Santé et de la Recherche Médicale (INSERM).

Paul subsequently joined Sir Magdi Yacoub at the newly formed National Heart and Lung Institute (NHLI) and established a team investigating molecular and cellular mechanisms of cardiac development and disease, supported by a 10 year Senior Research Fellowship from the British Heart Foundation. He later became Reader in Molecular Biology at NHLI and Assistant Director of Research at the Magdi Yacoub Institute, Harefield.

In 2011, Paul moved to a new post at The Royal Brompton Hospital, joining Professor Stuart Cook's newly formed Genetics and Genomics Group investigating Inherited Cardiac Conditions.

Paul has published over 170 research papers and contributed to many books including Gray’s Anatomy. He holds elected Fellowships from both the European Society of Cardiology (FESC) and the American Heart Association (FAHA).



Tayal U, gregson J, Buchan R, et al., 2021, Moderate excess alcohol consumption and adverse cardiac remodelling in dilated cardiomyopathy, Heart, ISSN:1355-6037

Simoes Monteiro de Marvao A, McGurk K, Zheng S, et al., 2021, Phenotypic Expression and Outcomes in Individuals with Rare Genetic Variants of Hypertrophic Cardiomyopathy, Journal of the American College of Cardiology, ISSN:0735-1097

Wright CF, Quaife NM, Ramos-Hernández L, et al., 2021, Non-coding region variants upstream of MEF2C cause severe developmental disorder through three distinct loss-of-function mechanisms, American Journal of Human Genetics, Vol:108, ISSN:0002-9297, Pages:1083-1094

Aguib Y, Allouba M, Walsh R, et al., 2021, A new variant with a previously unrecognized mechanism of pathogenicity in HCM, Circulation, ISSN:0009-7322

Whiffin N, Karczewski KJ, Zhang X, et al., 2021, Characterising the loss-of-function impact of 5 ' untranslated region variants in 15,708 individuals (vol 11, 2523, 2020), Nature Communications, Vol:12, ISSN:2041-1723, Pages:1-1

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