DrPaulBarton

Faculty of Medicine, National Heart & Lung Institute

Honorary Senior Research Fellow

Contact

Location

2054Sydney StreetRoyal Brompton Campus

Summary

Paul Barton is Senior Research Fellow at the National Heart and Lung Institute (NHLI), Imperial College London; Genetics Research Manager at the Royal Brompton & Harefield Hospitals, Guy’s and St. Thomas’ NHS Foundation Trust; and a founding member of the Cardiovascular Genetics and Genomics Group (cvgenetics.org). His research interests include the genetics of inherited cardiac conditions and the role of IL11 in cardiac disease.

Following a PhD in human genetics from the University of London, he undertook postdoctoral training at the Institut Pasteur Paris with Margaret Buckingham FRS, supported by fellowships from the Muscular Dystrophy Association of America (MDA) and European Molecular Biology Organization (EMBO) and later as a tenured staff scientist (CR1, Institut National de la Santé et de la Recherche Médicale; INSERM).

He was later recruited to the newly formed National Heart and Lung Institute (NHLI) by Professor Sir Magdi Yacoub OM FRS and established a team investigating molecular and cellular mechanisms of cardiac development and disease, supported initially by a 10-year Senior Research Fellowship from the British Heart Foundation. He later became Reader in Molecular Biology at NHLI and Assistant Director of Research at the Magdi Yacoub Institute, Harefield.

In 2011, Paul was recruited by Professor Stuart Cook to the newly formed Cardiovascular Genetics and Genomics Group at The Royal Brompton Hospital. He currently works jointly with Professors James Ware and Stuart Cook dividing his time between the Royal Brompton Hospital, NHLI Imperial College and the MRC London Institute of Medical Sciences (LMS).

Paul has published over 200 papers and contributed to a variety of books including Gray’s Anatomy. He currently holds elected Fellowships from both the European Society of Cardiology (FESC) and the American Heart Association (FAHA) and is Associate Editor for the Journal of Cardiovascular Translational Research.

Publications

Journals

Tadros R, Zheng SL, Grace C, et al.Tadros R, Zheng SL, Grace C, Jordà P, Francis C, Jurgens SJ, Thomson KL, Harper AR, Ormondroyd E, West DM, Xu X, Theotokis PI, Buchan RJ, McGurk KA, Mazzarotto F, Boschi B, Pelo E, Lee M, Noseda M, Varnava A, Vermeer AM, Walsh R, Amin AS, van Slegtenhorst MA, Roslin N, Strug LJ, Salvi E, Lanzani C, de Marvao A, Hypergenes InterOmics Collaborators, Roberts JD, Tremblay-Gravel M, Giraldeau G, Cadrin-Tourigny J, L'Allier PL, Garceau P, Talajic M, Pinto YM, Rakowski H, Pantazis A, Baksi J, Halliday BP, Prasad SK, Barton PJ, O'Regan DP, Cook SA, de Boer RA, Christiaans I, Michels M, Kramer CM, Ho CY, Neubauer S, HCMR Investigators, Matthews PM, Wilde AA, Tardif J-C, Olivotto I, Adler A, Goel A, Ware JS, Bezzina CR, Watkins H close, 2023, Large scale genome-wide association analyses identify novel genetic loci and mechanisms in hypertrophic cardiomyopathy., Medrxiv

Quaife NM, Chothani S, Schulz JF, et al.Quaife NM, Chothani S, Schulz JF, Lindberg EL, Vanezis K, Adami E, O'Fee K, Greiner J, Litviňuková M, van Heesch S, Whiffin N, Hubner N, Schafer S, Rackham O, Cook SA, Barton PJR close, 2023, LINC01013 is a determinant of fibroblast activation and encodes a novel fibroblast-activating micropeptide, Journal of Cardiovascular Translational Research, Vol:16, ISSN:1937-5387, Pages:77-85

Lota A, Hazebroek M, Theotokis P, et al.Lota A, Hazebroek M, Theotokis P, Wassall R, Salmi S, Halliday B, Tayal U, Verdonschot J, Meena D, Owen R, de Marvao A, Iacob A, Yazdani M, Hammersley D, Jones R, Wage R, Buchan R, Vivian F, Hafouda Y, Noseda M, Gregson J, Mittal T, Wong J, Robertus JL, Baksi AJ, Vassiliou V, Tzoulaki I, Pantazis A, Cleland J, Barton P, Cook S, Pennell D, Cooper L, Garcia-Pavia P, Heymans S, Ware J, Prasad S close, 2022, Genetic architecture of acute myocarditis and the overlap with inherited cardiomyopathy, Circulation, Vol:146, ISSN:0009-7322, Pages:1123-1134

Reichart D, Lindberg EL, Maatz H, et al.Reichart D, Lindberg EL, Maatz H, Miranda AMA, Viveiros A, Shvetsov N, Gaertner A, Nadelmann ER, Lee M, Kanemaru K, Ruiz-Orera J, Strohmenger V, DeLaughter DM, Patone G, Zhang H, Woehler A, Lippert C, Kim Y, Adami E, Gorham JM, Barnett SN, Brown K, Buchan RJ, Chowdhury RA, Constantinou C, Cranley J, Felkin LE, Fox H, Ghauri A, Gummert J, Kanda M, Li R, Mach L, McDonough B, Samari S, Shahriaran F, Yapp C, Stanasiuk C, Theotokis P, Theis FJ, van den Bogaerdt A, Wakimoto H, Ware JS, Worth CL, Barton PJR, Lee Y-A, Teichmann SA, Milting H, Noseda M, Oudit GY, Heinig M, Seidman JG, Hubner N, Seidman CE close, 2022, Pathogenic variants damage cell composition and single-cell transcription in cardiomyopathies, Science, Vol:377, ISSN:0036-8075, Pages:1-13

Tayal U, Verdonschot JAJ, Hazebroek MR, et al.Tayal U, Verdonschot JAJ, Hazebroek MR, Howard J, Gregson J, Newsome S, Gulati A, Pua CJ, Halliday BP, Lota AS, Buchan RJ, Whiffin N, Kanapeckaite L, Baruah R, Jarman JWE, O'Regan DP, Barton PJR, Ware JS, Pennell DJ, Adriaans BP, Bekkers SCAM, Donovan J, Frenneaux M, Cooper LT, Januzzi JL, Cleland JGF, Cook SA, Deo RC, Heymans SRB, Prasad SK close, 2022, Precision phenotyping of dilated cardiomyopathy using multidimensional data., Journal of the American College of Cardiology, Vol:79, ISSN:0735-1097, Pages:2219-2232

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