Imperial College London


Faculty of MedicineNational Heart & Lung Institute

Honorary Senior Research Fellow



+44 (0)20 7351 8140p.barton Website




RF 16Sydney StreetRoyal Brompton Campus





Paul Barton is Honorary Senior Research Fellow at the National Heart and Lung Institute working in the Cardiovascular Genetics and Genomics Group.

He gained his PhD in human genetics at the University of London in 1981 and undertook six years postdoctoral training in the Molecular Biology Department of the Pasteur Institute in Paris studying muscle protein genes under the direction of Dr Margaret Buckingham and supported by fellowships from the Muscular Dystrophy Association of America (MDA), the European Molecular Biology Organization (EMBO) and later, as a tenured scientist of the French Institut National de la Santé et de la Recherche Médicale (INSERM, equivalent UK MRC). 

In 1989 he joined Professor Sir Magdi Yacoub at the newly formed National Heart and Lung Institute (NHLI) in London in order to investigate molecular and cellular biology of cardiac development and disease supported by a 10 year Senior Research Fellowship from the British Heart Foundation. He also served as Assistant Director of Research to the Magdi Yacoub Institute, a charitable foundation established to support research into the causes and treatment of heart disease. In 2011 he joined Professor Stuart Cook's newly formed Genetics and Genomic's Group at the Cardiovascular Biomedical Research Unit, Royal Brompton and Harefield NHS Trust where he acts as research Manager  while remaining as Honorary Senior Research Fellow at NHLI.   

Dr Barton has published over 120 research papers and has been elected to Fellowship of both the European Society of Cardiology (FESC) and the American Heart Association (AHA). His research is currently funded by the UK National Institute of Health Research (NIHR), the European Commission (FP7, Cardionet-ITN), Wellcome Trust and Department of Health (DoH).

Selected Publications

Journal Articles

Schafer S, de Marvao A, Adami E, et al., 2017, Titin-truncating variants affect heart function in disease cohorts and the general population, Nature Genetics, Vol:49, ISSN:1061-4036, Pages:46-53

Felkin LE, Walsh R, Ware JS, et al., 2016, Recovery of Cardiac Function in Cardiomyopathy Caused by Titin Truncation, Jama Cardiology, Vol:1, ISSN:2380-6583, Pages:234-235

Roberts AM, Ware JS, Herman DS, et al., 2015, Integrated allelic, transcriptional, and phenomic dissection of the cardiac effects of titin truncations in health and disease., Sci Transl Med, Vol:7

Maatz H, Jens M, Liss M, et al., 2014, RNA-binding protein RBM20 represses splicing to orchestrate cardiac pre-mRNA processing., J Clin Invest, Vol:124, Pages:3419-3430

Herman DS, Lam L, Taylor MRG, et al., 2012, Truncations of Titin Causing Dilated Cardiomyopathy, New England Journal of Medicine, Vol:366, ISSN:0028-4793, Pages:619-628

McDermott-Roe C, Ye J, Ahmed R, et al., 2011, Endonuclease G is a novel determinant of cardiac hypertrophy and mitochondrial function, Nature, Vol:478, ISSN:0028-0836, Pages:114-118

Felkin LE, Narita T, Germack R, et al., 2011, Calcineurin Splicing Variant Calcineurin A beta 1 Improves Cardiac Function After Myocardial Infarction Without Inducing Hypertrophy, Circulation, Vol:123, ISSN:0009-7322, Pages:2838-2847

More Publications