Paul Barton is Senior Research Fellow at the National Heart and Lung Institute (NHLI), Imperial College London; Genetics Research Manager at the Royal Brompton & Harefield Hospitals, Guy’s and St. Thomas’ NHS Foundation Trust; and a founding member of the Cardiovascular Genetics and Genomics Group (cvgenetics.org). His research interests include the genetics of inherited cardiac conditions and the role of IL11 in cardiac disease.
Following a PhD in human genetics from the University of London, he undertook postdoctoral training at the Institut Pasteur Paris with Margaret Buckingham FRS, supported by fellowships from the Muscular Dystrophy Association of America (MDA) and European Molecular Biology Organization (EMBO) and later as a tenured staff scientist (CR1, Institut National de la Santé et de la Recherche Médicale; INSERM).
He was later recruited to the newly formed National Heart and Lung Institute (NHLI) by Professor Sir Magdi Yacoub OM FRS and established a team investigating molecular and cellular mechanisms of cardiac development and disease, supported initially by a 10-year Senior Research Fellowship from the British Heart Foundation. He later became Reader in Molecular Biology at NHLI and Assistant Director of Research at the Magdi Yacoub Institute, Harefield.
In 2011, Paul was recruited by Professor Stuart Cook to the newly formed Cardiovascular Genetics and Genomics Group at The Royal Brompton Hospital. He currently works jointly with Professors James Ware and Stuart Cook dividing his time between the Royal Brompton Hospital, NHLI Imperial College and the MRC London Institute of Medical Sciences (LMS).
Paul has published over 200 papers and contributed to a variety of books including Gray’s Anatomy. He currently holds elected Fellowships from both the European Society of Cardiology (FESC) and the American Heart Association (FAHA) and is Associate Editor for the Journal of Cardiovascular Translational Research.
et al., 2023, Large scale genome-wide association analyses identify novel genetic loci and mechanisms in hypertrophic cardiomyopathy., Medrxiv
et al., 2023, LINC01013 is a determinant of fibroblast activation and encodes a novel fibroblast-activating micropeptide, Journal of Cardiovascular Translational Research, Vol:16, ISSN:1937-5387, Pages:77-85
et al., 2022, Genetic architecture of acute myocarditis and the overlap with inherited cardiomyopathy, Circulation, Vol:146, ISSN:0009-7322, Pages:1123-1134
et al., 2022, Pathogenic variants damage cell composition and single-cell transcription in cardiomyopathies, Science, Vol:377, ISSN:0036-8075, Pages:1-13
et al., 2022, Precision phenotyping of dilated cardiomyopathy using multidimensional data., Journal of the American College of Cardiology, Vol:79, ISSN:0735-1097, Pages:2219-2232