Imperial College London


Faculty of MedicineNational Heart & Lung Institute

Honorary Senior Research Fellow



+44 (0)20 7351 8140p.barton Website




2054Sydney StreetRoyal Brompton Campus





Paul Barton is Senior Research Fellow at the National Heart and Lung Institute, Imperial College London; Genetics Research Manager at the Royal Brompton & Harefield Hospitals, Guy’s and St. Thomas’ NHS Foundation Trust; and a founding member of the Cardiovascular Genetics and Genomics Group ( His research interests include the genetics of inherited cardiac conditions and the role of IL11 in cardiac disease.

Paul obtained his PhD in human genetics from the University of London and undertook postdoctoral training at the Institut Pasteur Paris with Margaret Buckingham FRS, supported by fellowships from the Muscular Dystrophy Association of America (MDA) and European Molecular Biology Organization (EMBO) and later as a tenured staff scientist (CR1, Institut National de la Santé et de la Recherche Médicale; INSERM).

Paul was recruited to the newly formed National Heart and Lung Institute (NHLI) by Professor Sir Magdi Yacoub OM FRS and established a team investigating molecular and cellular mechanisms of cardiac development and disease, supported initially by a 10-year Senior Research Fellowship from the British Heart Foundation. He later became Reader in Molecular Biology at NHLI and Assistant Director of Research at the Magdi Yacoub Institute, Harefield.

In 2011, Paul was recruited by Professor Stuart Cook to the newly formed Cardiovascular Genetics and Genomics Group at The Royal Brompton Hospital, where he currently works jointly with Dr James Ware and Professor Stuart Cook. He has published over 200 papers and contributed to a variety of books including Gray’s Anatomy. He holds elected Fellowships from the European Society of Cardiology (FESC) and the American Heart Association (FAHA) and is Associate Editor for the Journal of Cardiovascular Translational Research.



Simoes Monteiro de Marvao A, McGurk K, Zheng S, et al., 2021, Phenotypic expression and outcomes in individuals with rare genetic variants of hypertrophic cardiomyopathy, Journal of the American College of Cardiology, Vol:78, ISSN:0735-1097, Pages:1097-1110

Aguib Y, Allouba M, Walsh R, et al., 2021, New variant with a previously unrecognized mechanism of pathogenicity in hypertrophic cardiomyopathy, Circulation, Vol:144, ISSN:0009-7322, Pages:754-757

Patel PN, Ito K, Willcox JAL, et al., 2021, Contribution of noncanonical splice variants to TTN truncating variants cardiomyopathy, Circulation: Genomic and Precision Medicine, Vol:14, ISSN:2574-8300, Pages:1-10

Tayal U, gregson J, Buchan R, et al., 2021, Moderate excess alcohol consumption and adverse cardiac remodelling in dilated cardiomyopathy, Heart, ISSN:1355-6037

Wright CF, Quaife NM, Ramos-Hernández L, et al., 2021, Non-coding region variants upstream of MEF2C cause severe developmental disorder through three distinct loss-of-function mechanisms, American Journal of Human Genetics, Vol:108, ISSN:0002-9297, Pages:1083-1094

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