Summary
Paul Barton is Senior Research Fellow at the National Heart and Lung Institute (NHLI), Imperial College London; Genetics Research Manager at the Royal Brompton & Harefield Hospitals, Guy’s and St. Thomas’ NHS Foundation Trust; and a founding member of the Cardiovascular Genetics and Genomics Group (cvgenetics.org). His research interests include the genetics of inherited cardiac conditions and the role of IL11 in cardiac disease.
Following a PhD in human genetics from the University of London, he undertook postdoctoral training at the Institut Pasteur Paris with Margaret Buckingham FRS, supported by fellowships from the Muscular Dystrophy Association of America (MDA) and European Molecular Biology Organization (EMBO) and later as a tenured staff scientist (CR1, Institut National de la Santé et de la Recherche Médicale; INSERM).
He was later recruited to the newly formed National Heart and Lung Institute (NHLI) by Professor Sir Magdi Yacoub OM FRS and established a team investigating molecular and cellular mechanisms of cardiac development and disease, supported initially by a 10-year Senior Research Fellowship from the British Heart Foundation. He later became Reader in Molecular Biology at NHLI and Assistant Director of Research at the Magdi Yacoub Institute, Harefield.
In 2011, Paul was recruited by Professor Stuart Cook to the newly formed Cardiovascular Genetics and Genomics Group at The Royal Brompton Hospital. He currently works jointly with Professors James Ware and Stuart Cook dividing his time between the Royal Brompton Hospital, NHLI Imperial College and the MRC London Institute of Medical Sciences (LMS).
Paul has published over 200 papers and contributed to a variety of books including Gray’s Anatomy. He currently holds elected Fellowships from both the European Society of Cardiology (FESC) and the American Heart Association (FAHA) and is Associate Editor for the Journal of Cardiovascular Translational Research.
Publications
Journals
Ochoa JP, Lalaguna L, Mirelis JG, et al., 2024, Biallelic Loss of Function Variants in Myocardial Zonula Adherens Protein Gene (MYZAP) Cause a Severe Recessive Form of Dilated Cardiomyopathy., Circ Heart Fail, Vol:17
Owen R, Buchan R, Frenneaux M, et al., 2024, Sex differences in the clinical presentation and natural history of dilated cardiomyopathy, Jacc: Heart Failure, Vol:12, ISSN:2213-1787, Pages:352-363
Allouba M, Walsh R, Afify A, et al., 2023, Ethnicity, consanguinity, and genetic architecture of hypertrophic cardiomyopathy, European Heart Journal, Vol:44, ISSN:0195-668X, Pages:5146-5158
McGurk K, Zhang X, Theotokis P, et al., 2023, The penetrance of rare variants in cardiomyopathy-associated genes: a cross-sectional approach to estimate penetrance for secondary findings, American Journal of Human Genetics, Vol:110, ISSN:0002-9297, Pages:1482-1495
Sweeney M, O'Fee K, Villanueva-Hayes C, et al., 2023, Cardiomyocyte-restricted expression of IL11 causes cardiac fibrosis, inflammation, and dysfunction, International Journal of Molecular Sciences, Vol:24, ISSN:1422-0067, Pages:1-14