Publications

BibTex format

@article{Felkin:2016:10.1001/jamacardio.2016.0208,
author = {Felkin, LE and Walsh, R and Ware, JS and Yacoub, MH and Birks, EJ and Barton, PJR and Cook, SA},
doi = {10.1001/jamacardio.2016.0208},
journal = {JAMA Cardiology},
pages = {234--235},
title = {Recovery of cardiac function in cardiomyopathy due to titin truncation},
url = {http://dx.doi.org/10.1001/jamacardio.2016.0208},
volume = {1},
year = {2016}
}

Download

RIS format (EndNote, RefMan)

TY  - JOUR
AB  - Dilated cardiomyopathy (DCM) is a frequent cause of heart failure and a common indication for heart transplantation. Dilated cardiomyopathy has a strong genetic basis, and the most common disease-causing mutations are variants that truncate the sarcomeric protein titin (TTN-truncating variants [TTNtvs] are prevalent in 25%1 of familial DCM cases and 13%2 of idiopathic DCM cases). The prognosis of DCM is poor, but functional recovery from end-stage failure has been reported following both optimal medical therapy3 and left ventricular assist device (LVAD) support,4,5 although the determinants of successful recovery are unknown. It has been proposed that recovery from genetic cardiomyopathy may not be expected because the underlying cause is irreversible, whereas recovery may be more likely when DCM is caused by reversible, nongenetic factors (eg, myocarditis).6 To address this directly, we sequenced TTN in patients with end-stage DCM who either recovered or did not recover following LVAD support.
AU  - Felkin,LE
AU  - Walsh,R
AU  - Ware,JS
AU  - Yacoub,MH
AU  - Birks,EJ
AU  - Barton,PJR
AU  - Cook,SA
DO  - 10.1001/jamacardio.2016.0208
EP  - 235
PY  - 2016///
SN  - 2380-6583
SP  - 234
TI  - Recovery of cardiac function in cardiomyopathy due to titin truncation
T2  - JAMA Cardiology
UR  - http://dx.doi.org/10.1001/jamacardio.2016.0208
UR  - http://hdl.handle.net/10044/1/30878
VL  - 1
ER  -

Download

DrPaulBarton

Contact

Location

Summary

Citation

BibTex format

RIS format (EndNote, RefMan)