Publications
129 results found
Kakar P, Kamdar A, Prabhudev H, et al., 2012, Diagnostic confusion resolved by being upbeat, JRSM Cardiovascular Disease, Vol: 1, Pages: 6-6, ISSN: 2048-0040
Slark J, Bentley P, Sharma P, 2012, Silent brain infarction in the presence of systemic vascular disease, JRSM Cardiovascular Disease, Vol: 1, Pages: 1-9, ISSN: 2048-0040
ObjectiveTo determine the prevalence of asymptomatic brain ischaemic in the presence of vascular disease in other arterial territories.DesignStudies up to January 2011 were identified through comprehensive search strategies. Arcsine transformation for metaanalysis was used to calculate the standardized mean difference (SMD) and 95% confidence intervals (CI).SettingA systematic review and meta-analysis were performed.ParticipantsFor each study, the proportion of patients positive for SBI in the presence of other systemic vascular disease was extracted and analyzed.Main outcome measuresUsing a random-effects model, a pooled effect estimate interpreted as a percentage prevalence of disease was calculated.ResultsSBI in the presence of acute ischaemic stroke was found in 23% (SMD 0.99; P < 0.001; 95% CI 0.88-1.10); a 35% prevalence was found in patients with coronary artery disease (SMD 1.26; P < 0.001; 95% CI 0.95-1.58); and a 14% prevalence in patients with peripheral artery disease (SMD 0.48; P< 0.002; 95% CI 0.42-0.54), although the data-set in the latter is smaller.ConclusionsPatients with systemic vascular disease are at an increased risk of silent brain infarction.
Hasan N, McColgan P, Bentley P, et al., 2012, Towards the identification of blood biomarkers for acute stroke in humans: a comprehensive systematic review., Br J Clin Pharmacol
Sandercock P, Lindley R, Wardlaw J, et al., 2011, Update on the third international stroke trial (IST-3) of thrombolysis for acute ischaemic stroke and baseline features of the 3035 patients recruited, Trials, Vol: 12, Pages: 1-9, ISSN: 1745-6215
BackgroundIntravenous recombinant tissue plasminogen activator (rtPA) is approved in Europe for use in patients with acute ischaemic stroke who meet strictly defined criteria. IST-3 sought to improve the external validity and precision of the estimates of the overall treatment effects (efficacy and safety) of rtPA in acute ischaemic stroke, and to determine whether a wider range of patients might benefit.DesignInternational, multi-centre, prospective, randomized, open, blinded endpoint (PROBE) trial of intravenous rtPA in acute ischaemic stroke. Suitable patients had to be assessed and able to start treatment within 6 hours of developing symptoms, and brain imaging must have excluded intracranial haemorrhage and stroke mimics.ResultsThe initial pilot phase was double blind and then, on 01/08/2003, changed to an open design. Recruitment began on 05/05/2000 and closed on 31/07/2011, by which time 3035 patients had been included, only 61 (2%) of whom met the criteria for the 2003 European approval for thrombolysis. 1617 patients were aged over 80 years at trial entry. The analysis plan will be finalised, without reference to the unblinded data, and published before the trial data are unblinded in early 2012. The main trial results will be presented at the European Stroke Conference in Lisbon in May 2012 with the aim to publish simultaneously in a peer-reviewed journal. The trial result will be presented in the context of an updated Cochrane systematic review. We also intend to include the trial data in an individual patient data meta-analysis of all the relevant randomised trials.ConclusionThe data from the trial will: improve the external validity and precision of the estimates of the overall treatment effects (efficacy and safety) of iv rtPA in acute ischaemic stroke; provide: new evidence on the balance of risk and benefit of intravenous rtPA among types of patients who do not clearly meet the terms of the current EU approval; and, provide the first large-scale rand
Bentley P, Rosso M, Sadnicka A, et al., 2011, Intravenous immunoglobulin increases plasma viscosity without parallel rise in blood pressure., J Clin Pharm Ther.
Bentley P, Driver J, Dolan RJ, 2011, Cholinergic modulation of cognition: Insights from human pharmacological functional neuroimaging, PROGRESS IN NEUROBIOLOGY, Vol: 94, Pages: 360-388, ISSN: 0301-0082
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- Citations: 120
Devine M, Bentley P, Jones B, et al., 2011, PERSISTENT PSYCHOSIS IN THREE SUSCEPTIBLE INDIVIDUALS WITH RIGHT INFERIOR FRONTAL LOBE STROKE, 15th Congress of the European-Federation-of-Neurological-Societies (EFNS), Publisher: WILEY-BLACKWELL, Pages: 420-420, ISSN: 1351-5101
Bentley P, Wang T, Malik O, et al., 2011, CADASIL with cord involvement associated with a novel and atypical NOTCH3 mutation, JOURNAL OF NEUROLOGY NEUROSURGERY AND PSYCHIATRY, Vol: 82, Pages: 855-860, ISSN: 0022-3050
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- Citations: 24
Yadav S, Bentley P, Srivastava P, et al., 2011, The First Indian-Origin Family with Genetically Proven Cerebral Autosomal Dominant Arteriopathy with Subcortical Infarcts and Leukoencephalopathy (CADASIL)., J Stroke Cerebrovasc Dis
McColgan P, Sharma P, Bentley P, 2011, Stem Cell Tracking in Human Trials: A Meta-Regression, Stem Cell Rev Reports
Marjot T, Yadav S, Hasan N, et al., 2011, Genes associated with adult cerebral venous thrombosis., Stroke, Vol: 4, Pages: 913-918
Yadav S, Schanz R, Maheshwari A, et al., 2011, Bio-Repository of DNA in stroke (BRAINS): A study protocol, BMC Medical Genetics, Vol: 12, Pages: 12-34, ISSN: 1471-2350
BackgroundStroke is one of the commonest causes of mortality in the world and anticipated to be an increasing burden to the developing world. Stroke has a genetic basis and identifying those genes may not only help us define the mechanisms that cause stroke but also identify novel therapeutic targets. However, large scale highly phenotyped DNA repositories are required in order for this to be achieved.MethodsThe proposed Bio-Repository of DNA in Stroke (BRAINS) will recruit all subtypes of stroke as well as controls from two different continents, Europe and Asia. Subjects recruited from the UK will include stroke patients of European ancestry as well as British South Asians. Stroke subjects from South Asia will be recruited from India and Sri Lanka. South Asian cases will also have control subjects recruited.DiscussionWe describe a study protocol to establish a large and highly characterized stroke biobank in those of European and South Asian descent. With different ethnic populations being recruited, BRAINS has the ability to compare and contrast genetic risk factors between those of differing ancestral descent as well as those who migrate into different environments.
Bentley P, 2011, Parkinson's Disease, Epilepsy, Multiple Sclerosis and other neurological disorders, In: Clinical Pharmacology, Editors: Bennett, Brown, Sharma, Publisher: Elsevier
Slark J, Bentley P, Majeed A, et al., 2010, Awareness of Stroke Symptomatology and Cardiovascular Risk Factors Amongst Stroke Survivors., J Stroke Cerebrovasc Dis.
Bentley P, Weil R, 2010, Central Nervous System Cases In: Ost: Clinical Medicine for the MRCP Paces: Volume 1: Core Clinical Skills, Ost: Clinical Medicine for the MRCP Paces: Volume 1: Core Clinical Skills, Editors: Mehta, Iqbal, Publisher: Oxford Univ Pr, ISBN: 9780199542550
Volume 1 of a two volume MRCP text, this book includes cases which mimic the style and approach of the MRCP PACES exam.
Sharma P, Bentley P, 2010, Down but not out: candidate gene-based studies still have value in a world dominated by whole genome approaches., Circ Res, Pages: 1019-1021
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Bentley P, Peck G, Smeeth L, et al., 2010, Causal relationship of susceptibility genes to ischemic stroke: comparison to ischemic heart disease and biochemical determinants., PLoS One, Vol: 5, Pages: e9136(1)-e9136(15), ISSN: 1932-6203
Interrelationships between genetic and biochemical factors underlying ischemic stroke and ischemic heart disease are poorly understood. We: 1) undertook the most comprehensive meta-analysis of genetic polymorphisms in ischemic stroke to date; 2) compared genetic determinants of ischemic stroke with those of ischemic heart disease, and 3) compared effect sizes of gene-stroke associations with those predicted from independent biochemical data using a mendelian randomization strategy. Electronic databases were searched up to January 2009. We identified: 1) 187 ischemic stroke studies (37,481 cases; 95,322 controls) interrogating 43 polymorphisms in 29 genes; 2) 13 meta-analyses testing equivalent polymorphisms in ischemic heart disease; and 3) for the top five gene-stroke associations, 146 studies (65,703 subjects) describing equivalent gene-biochemical relationships, and 28 studies (46,928 subjects) describing biochemical-stroke relationships. Meta-analyses demonstrated positive associations with ischemic stroke for factor V Leiden Gln506, ACE I/D, MTHFR C677T, prothrombin G20210A, PAI-1 5G allele and glycoprotein IIIa Leu33Pro polymorphisms (ORs: 1.11 - 1.60). Most genetic associations show congruent levels of risk comparing ischemic stroke with ischemic heart disease, but three genes--glycoprotein IIIa, PAI-1 and angiotensinogen--show significant dissociations. The magnitudes of stroke risk observed for factor V Leiden, ACE, MTHFR and prothrombin, but not PAI-1, polymorphisms, are consistent with risks associated with equivalent changes in activated protein C resistance, ACE activity, homocysteine, prothrombin, and PAI-1 levels, respectively. Our results demonstrate causal relationships for four of the most robust genes associated with stroke while also showing that PAI-1 4G/5G polymorphism influences cardiovascular risk via a mechanism not simply related to plasma levels of PAI-1 (or tPA) alone.
Bentley P, Driver J, Dolan RJ, 2009, Modulation of fusiform cortex activity by cholinesterase inhibition predicts effects on subsequent memory, BRAIN, Vol: 132, Pages: 2356-2371, ISSN: 0006-8950
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- Citations: 33
Bentley P, Jovanovic A, Sharma P, 2008, Cultural diversity training for UK healthcare professionals: a comprehensive nationwide cross-sectional survey, CLINICAL MEDICINE, Vol: 8, Pages: 493-497, ISSN: 1470-2118
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- Citations: 21
McGinnity CJ, Bentley P, Abdul-Salam V, et al., 2008, Proteome-wide search for biomarkers in acute ischaemic stroke, J HUM HYPERTENS, Vol: 22, Pages: 721-721, ISSN: 0950-9240
Bentley P, Wang T, Malik O, et al., 2008, Another notch in the cellular and clinical characterisation of CADASIL, Annual Meeting of the Association-of-British-Neurologists, Publisher: B M J PUBLISHING GROUP, Pages: 348-348, ISSN: 0022-3050
Bentley P, Driver J, Dolan RJ, 2008, Cholinesterase inhibition modulates visual and attentional brain responses in Alzheimer's disease and health, BRAIN, Vol: 131, Pages: 409-424, ISSN: 0006-8950
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- Citations: 86
Bentley P, Sharma P, 2007, Prothrombotic States and Related Conditions, Neurology and Clinical Neuroscience, Pages: 609-620, ISBN: 9780323033541
Bentley P, Qadri F, Wild EJ, et al., 2007, Vasculitic presentation of staphylococcal meningitis, Arch Neurol, Pages: 1788-1799
Bentley P, 2007, Memorizing medicine, Publisher: Royal Society of Medicine Pr Ltd, ISBN: 9781853154201
This book takes an original approach to applying well-establishedpsychologicaltechniques in memory enhancement to the contents of standard medical textbooks.
Bentley P, Sharma P, 2006, Prothrombotic States and Related Conditions, Neurology and Clinical Neuroscience: Text with CD-ROM, Pages: 609-620, ISBN: 9780323070539
Bentley P, Sharma P, 2005, Pharmacological treatment of ischemic stroke, PHARMACOLOGY & THERAPEUTICS, Vol: 108, Pages: 334-352, ISSN: 0163-7258
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- Citations: 5
Sharma P, Bentley P, 2005, Of rats and men: superwarfarin toxicity, LANCET, Vol: 365, Pages: 552-554, ISSN: 0140-6736
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- Citations: 20
Bentley P, Husain M, Dolan RJ, 2004, Effects of cholinergic enhancement on visual stimulation, spatial attention, and spatial working memory, NEURON, Vol: 41, Pages: 969-982, ISSN: 0896-6273
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- Citations: 137
Mijovic-Prelec D, Bentley P, Caviness VS, 2004, Selective rotation of egocentric spatial representation following right putaminal hemorrhage, NEUROPSYCHOLOGIA, Vol: 42, Pages: 1827-1837, ISSN: 0028-3932
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- Citations: 5
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