Publications
129 results found
Mace M, Rinne P, Liardon J, et al., 2015, Comparison of flexible and rigid hand-grip control during a feed-forward visual tracking task, Rehabilitation Robotics (ICORR), 2015 IEEE International Conference on, ISSN: 1945-7901
Tran T, Cotlarciuc I, Yadav S, et al., 2015, Candidate-gene analysis of white matter hyperintensities on neuroimaging, Journal of Neurology, Neurosurgery & Psychiatry, Vol: 87, Pages: 260-266, ISSN: 0022-3050
Lobotesis K, Mahady K, Ganesalingam J, et al., 2015, COILING-ASSOCIATED DELAYED CEREBRAL HYPERSENSITIVITY: IS NICKEL THE LINK?, NEUROLOGY, Vol: 84, Pages: 97-99, ISSN: 0028-3878
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- Citations: 14
Chen L, Tong T, Ho CP, et al., 2015, Identification of Cerebral Small Vessel Disease Using Multiple Instance Learning, MEDICAL IMAGE COMPUTING AND COMPUTER-ASSISTED INTERVENTION - MICCAI 2015, PT I, Vol: 9349, Pages: 523-530, ISSN: 0302-9743
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- Citations: 10
Mace M, Rinne P, Liardon J-L, et al., 2015, Comparison of flexible and rigid hand-grip control during a feed-forward visual tracking task, 14th IEEE/RAS-EMBS International Conference on Rehabilitation Robotics (ICORR), Publisher: IEEE, Pages: 792-797, ISSN: 1945-7898
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- Citations: 6
Majersik MJJ, Cole JW, Golledge J, et al., 2014, Recommendations From the International Stroke Genetics Consortium, Part 1: Standardized Phenotypic Data Collection, Stroke
Lobotesis K, Mahady K, Ganesalingam J, et al., 2014, Coiling-associated delayed cerebral hypersensitivity: Is nickel the link?, Neurology
Epton S, Bentley P, Ganesalingam J, et al., 2014, CTBRAIN MACHINE LEARNING PREDICTS STROKE THROMBOLYSIS RESULT, Meeting of the Associatiion-of-British-Neurologists, Publisher: BMJ PUBLISHING GROUP, ISSN: 0022-3050
Bentley P, Kumar G, Rinne P, et al., 2014, Lesion locations influencing baseline severity and early recovery in ischaemic stroke, EUROPEAN JOURNAL OF NEUROLOGY, Vol: 21, Pages: 1226-1232, ISSN: 1351-5101
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- Citations: 11
Banerjee S, Bentley P, Hamady M, et al., 2014, Intra-Arterial Immunoselected CD34+ Stem Cells for Acute Ischemic Stroke, Stem Cells Transl Med, Vol: pii: sctm.2013-0178. [Epub ahead of print]
Slark J, Khan MS, Bentley P, et al., 2014, Knowledge of blood pressure in a UK general public population, JOURNAL OF HUMAN HYPERTENSION, Vol: 28, Pages: 500-503, ISSN: 0950-9240
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- Citations: 6
de Bourbon-Teles J, Bentley P, Koshino S, et al., 2014, Thalamic control of human attention driven by memory and learning, Current Biology, Vol: 24, Pages: 993-999, ISSN: 0960-9822
The role of the thalamus in high-level cognition—attention, working memory (WM), rule-based learning, and decision making—remains poorly understood, especially in comparison to that of cortical frontoparietal networks [1, 2, 3]. Studies of visual thalamus have revealed important roles for pulvinar and lateral geniculate nucleus in visuospatial perception and attention [4, 5, 6, 7, 8, 9, 10] and for mediodorsal thalamus in oculomotor control [11]. Ventrolateral thalamus contains subdivisions devoted to action control as part of a circuit involving the basal ganglia [12, 13] and motor, premotor, and prefrontal cortices [14], whereas anterior thalamus forms a memory network in connection with the hippocampus [15]. This connectivity profile suggests that ventrolateral and anterior thalamus may represent a nexus between mnemonic and control functions, such as action or attentional selection. Here, we characterize the role of thalamus in the interplay between memory and visual attention. We show that ventrolateral lesions impair the influence of WM representations on attentional deployment. A subsequent fMRI study in healthy volunteers demonstrates involvement of ventrolateral and, notably, anterior thalamus in biasing attention through WM contents. To further characterize the memory types used by the thalamus to bias attention, we performed a second fMRI study that involved learning of stimulus-stimulus associations and their retrieval from long-term memory to optimize attention in search. Responses in ventrolateral and anterior thalamic nuclei tracked learning of the predictiveness of these abstract associations and their use in directing attention. These findings demonstrate a key role for human thalamus in higher-level cognition, notably, in mnemonic biasing of attention.
Bentley P, Ganesalingam J, Jones ALC, et al., 2014, Prediction of stroke thrombolysis outcome using CT brain machine learning, NeuroImage: Clinical, Vol: 4, Pages: 635-640, ISSN: 2213-1582
A critical decision-step in the emergency treatment of ischemic stroke is whether or not to administer thrombolysis — a treatment that can result in good recovery, or deterioration due to symptomatic intracranial haemorrhage (SICH). Certain imaging features based upon early computerized tomography (CT), in combination with clinical variables, have been found to predict SICH, albeit with modest accuracy. In this proof-of-concept study, we determine whether machine learning of CT images can predict which patients receiving tPA will develop SICH as opposed to showing clinical improvement with no haemorrhage. Clinical records and CT brains of 116 acute ischemic stroke patients treated with intravenous thrombolysis were collected retrospectively (including 16 who developed SICH). The sample was split into training (n = 106) and test sets (n = 10), repeatedly for 1760 different combinations. CT brain images acted as inputs into a support vector machine (SVM), along with clinical severity. Performance of the SVM was compared with established prognostication tools (SEDAN and HAT scores; original, or after adaptation to our cohort). Predictive performance, assessed as area under receiver-operating-characteristic curve (AUC), of the SVM (0.744) compared favourably with that of prognostic scores (original and adapted versions: 0.626–0.720; p < 0.01). The SVM also identified 9 out of 16 SICHs, as opposed to 1–5 using prognostic scores, assuming a 10% SICH frequency (p < 0.001). In summary, machine learning methods applied to acute stroke CT images offer automation, and potentially improved performance, for prediction of SICH following thrombolysis. Larger-scale cohorts, and incorporation of advanced imaging, should be tested with such methods.
Devine MJ, Bentley P, Jones B, et al., 2014, The role of the right inferior frontal gyrus in the pathogenesis of post-stroke psychosis, JOURNAL OF NEUROLOGY, Vol: 261, Pages: 600-603, ISSN: 0340-5354
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- Citations: 33
Banerjee S, Bentley P, Hamady M, et al., 2014, Intra-arterial immunoselected CD34+ stem cells for acute ischemic stroke, Stem Cells Translational Medicine, Vol: 3, Pages: 1322-1331, ISSN: 2157-6564
Treatment with CD34+ hematopoietic stem/progenitor cells has been shown to improve functional recovery in nonhuman models of ischemic stroke via promotion of angiogenesis and neurogenesis. We aimed to determine the safety and feasibility of treatment with CD34+ cells delivered intraarterially in patients with acute ischemic stroke. This was the first study in human subjects. We performed a prospective, nonrandomized, open-label, phase I study of autologous, immunoselected CD34+ stem/progenitor cell therapy in patients presenting within 7 days of onset with severe anterior circulation ischemic stroke (National Institutes of Health Stroke Scale [NIHSS] score ‡8). CD34+ cells were collected from the bone marrow of the subjects before being delivered by catheter angiography into the ipsilesional middle cerebral artery. Eighty-two patients with severe anterior circulation ischemic stroke were screened, of whom five proceeded to treatment. The common reasons for exclusion were age >80 years (n = 19); medical instability (n = 17), and significant carotid stenosis (n = 13). The procedure was well tolerated in all patients, and no significant treatment-related adverse effects occurred. All patients showed improvements in clinical functional scores (Modified Rankin Score and NIHSS score) and reductions in lesion volume during a 6-month follow-up period. Autologous CD34+ selected stem/progenitor cell therapy delivered intra-arterially into the infarct territory can be achieved safely in patients with acute ischemic stroke. Future studies that address eligibility criteria, dosage, delivery site, and timing and that use surrogate imaging markers of outcome are desirable before larger scale clinical trials.
Slark J, Khan MS, Bentley P, et al., 2014, Individual Risk Awareness Intervention in Stroke (IRAIS): A Randomized Controlled Trial., J Neurol Disord Stroke, Vol: 1035
Rinne PE, Soto D, Sharma P, et al., 2014, Post-exercise brain network connectivity modulations in motor stroke, CEREBROVASCULAR DISEASES, Vol: 37, Pages: 46-46, ISSN: 1015-9770
Meschia JF, Arnett DK, Ay H, et al., 2013, Stroke Genetics Network (SiGN) Study: Design and Rationale for a Genome-Wide Association Study of Ischemic Stroke Subtypes., Stroke
Meta-analyses of extant genome-wide data illustrate the need to focus on subtypes of ischemic stroke for gene discovery. The National Institute of Neurological Disorders and Stroke SiGN (Stroke Genetics Network) contributes substantially to meta-analyses that focus on specific subtypes of stroke.
Rinne P, Hassan M, Goniotakis D, et al., 2013, Triple dissociation of attention networks in stroke according to lesion location, NEUROLOGY, Vol: 81, Pages: 812-820, ISSN: 0028-3878
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- Citations: 39
Yadav S, Hasan N, Marjot T, et al., 2013, Detailed Analysis of Gene Polymorphisms Associated with Ischemic Stroke in South Asians, PLOS ONE, Vol: 8, ISSN: 1932-6203
The burden of stroke is disproportionately high in the South Asian subcontinent with South Asian ethnicity conferring a greater risk of ischemic stroke than European ancestry regardless of country inhabited. While genes associated with stroke in European populations have been investigated, they remain largely unknown in South Asians. We conducted a comprehensive meta-analysis of known genetic polymorphisms associated with South Asian ischemic stroke, and compared effect size of the MTHFR C677T-stroke association with effect sizes predicted from homocysteine-stroke association. Electronic databases were searched up to August 2012 for published case control studies investigating genetic polymorphisms associated with ischemic stroke in South Asians. Pooled odds ratios (OR) for each gene-disease association were calculated using a random-effects model. We identified 26 studies (approximately 2529 stroke cases and 2881 controls) interrogating 33 independent genetic polymorphisms in 22 genes. Ten studies described MTHFR C677T (108 with TT genotype and 2018 with CC genotype) -homocysteine relationship and six studies (735 stroke cases and 713 controls) described homocysteine-ischemic stroke relationship. Risk association ORs were calculated for ACE I/D (OR 5.00; 95% CI, 1.17–21.37; p = 0.03), PDE4D SNP 83 (OR 2.20; 95% CI 1.21–3.99; p = 0.01), PDE4D SNP 32 (OR 1.57; 95% CI 1.01–2.45, p = 0.045) and IL10 G1082A (OR 1.44; 95% CI, 1.09–1.91, p = 0.01). Significant association was observed between elevated plasma homocysteine levels and MTHFR/677 TT genotypes in healthy South Asians (Mean difference (ΔX) 5.18 µmol/L; 95% CI 2.03–8.34: p = 0.001). Our results demonstrate that the genetic etiology of ischemic stroke in South Asians is broadly similar to the risk conferred in Europeans, although the dataset is considerably smaller and warrants the same clinical considerations for risk profiling.
Yadav S, Bentley P, Srivastava P, et al., 2013, The First Indian-Origin Family with Genetically Proven Cerebral Autosomal Dominant Arteriopathy with Subcortical Infarcts and Leukoencephalopathy (CADASIL), JOURNAL OF STROKE & CEREBROVASCULAR DISEASES, Vol: 22, Pages: 28-31, ISSN: 1052-3057
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- Citations: 4
Bentley P, Kumar G, Rinne P, et al., 2013, Influence of lesion location on early recovery in acute ischemic stroke: a voxel-lesion mapping study of 550 patients, CEREBROVASCULAR DISEASES, Vol: 35, Pages: 19-19, ISSN: 1015-9770
McColgan P, Bentley P, McCarron M, et al., 2012, Evaluation of the clinical utility of a carotid bruit, QJM-AN INTERNATIONAL JOURNAL OF MEDICINE, Vol: 105, Pages: 1171-1177, ISSN: 1460-2725
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- Citations: 14
Kaski D, Bentley P, Lane R, et al., 2012, Up-Down Asymmetry of Saccadic Contrapulsion in Lateral Medullary Syndrome, JOURNAL OF NEURO-OPHTHALMOLOGY, Vol: 32, Pages: 224-226, ISSN: 1070-8022
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- Citations: 5
Bentley P, Sharma P, 2012, Neurological disorders - epilepsy, Parkinson's disease and multiple sclerosis, Clinical Pharmacology: Eleventh Edition, Pages: 349-370, ISBN: 9780702040849
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- Citations: 3
Hasan N, McColgan P, Bentley P, et al., 2012, Towards the identification of blood biomarkers for acute stroke in humans: a comprehensive systematic review, BRITISH JOURNAL OF CLINICAL PHARMACOLOGY, Vol: 74, Pages: 230-240, ISSN: 0306-5251
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- Citations: 80
Slark J, Bentley P, Majeed A, et al., 2012, Awareness of Stroke Symptomatology and Cardiovascular Risk Factors Amongst Stroke Survivors, JOURNAL OF STROKE & CEREBROVASCULAR DISEASES, Vol: 21, Pages: 358-362, ISSN: 1052-3057
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- Citations: 26
Sandercock P, Wardlaw JM, Lindley RI, et al., 2012, The benefits and harms of intravenous thrombolysis with recombinant tissue plasminogen activator within 6 h of acute ischaemic stroke (the third international stroke trial [IST-3]): a randomised controlled trial, LANCET, Vol: 379, Pages: 2352-2363, ISSN: 0140-6736
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- Citations: 862
Bentley P, Rosso M, Sadnicka A, et al., 2012, Intravenous immunoglobulin increases plasma viscosity without parallel rise in blood pressure, JOURNAL OF CLINICAL PHARMACY AND THERAPEUTICS, Vol: 37, Pages: 286-290, ISSN: 0269-4727
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- Citations: 18
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