Dr Bhavsar has established himself as a fully independent researcher within the National Heart and Lung Institute and his research focuses on the mechanisms underlying relative steroid insensitivity in severe asthma and Chornic Obstructive Pulmonary Disease (COPD). Dr Bhavsar has gained an international reputation and visibility within the field of severe asthma. For example, he has recently been invited to visit the Guangzhou Institute of Respiratory Disease, China to present an overview his research and discuss co-operation on mechanisms of severe asthma. Dr Bhavsar has also developed extremely good relationships with the pharmaceutical industry, notably GlaxoSmithKline and Merck Corporation who have provided funding for research and have extended invitations to present at relevant workshops and symposia and has been asked to contribute Medical Scientific Liaison literature explaining the mechanisms of action identified from his research on newly licensed drugs. Dr Bhavsar is a regular chair and facilitator for symposia, poster discussion sessions and thematic poster sessions at the International Conferences of the American Thoracic Society and at the European Respiratory Society.
Dr Bhavsar has demonstrated his research expertise through the publication of a number of significant research papers as lead author in top respiratory journals such as American Journal of Respiratory and Critical Care Medicine, Journal of Allergy and Clinical Immunology and Thorax. He has also been successful in securing considerable research funding from the pharmaceutical industry, as well as the Research Councils and other charitable sources. He has recently been invited to become an Investigator at the MRC Asthma-UK Centre in Allergic Mechanisms of Asthma.
Dr Bhavsar has recently reported a new mechanism for corticosteroid insensitivity specific to the airway smooth muscle (ASM) of patients with severe asthma that involves impaired nuclear translocation of the glucocorticoid receptor. It is this observation which provides the basis of his ongoing basic research of corticosteroid insensitivity in severe asthma. His most recent collaborative research with Pharma identified molecular interaction between LABA and LAMA, a study which is unique, world leading and complements clinical trial findings assessing new bronchodilatory therapies for COPD and asthma.
Dr Bhavsar was awarded his PhD from the University of London (NHLI) in 1995, studying the molecular mechanisms underlying cardiac-specific gene regulation, under the supervision of Drs Paul Barton and Nigel Brand in the department of Cardiothoracic Surgery headed by Professor Sir Magdi Yacoub FRS. Dr Bhavsar became a Principal Investigator 18 months into his post-doctoral career with the award of a project grant from The British Heart Foundation. In 2001 Dr Bhavsar was promoted to Research Lecturer and worked on the ‘bridge to recovery’ programme, designed by Prof. Yacoub, seeking alternative surgical treatments for end-stage heart failure. In recognition of his research, and other contributions to the College including undergraduate and post-graduate student supervision and teaching, Dr Bhavsar was been promoted to Senior Research Fellow in September 2015.
In addition to his academic work, Dr Bhavsar is also a reviewer for major funding bodies and international basic science and clinical journals.
Recent publications and media coverage
et al., 2021, Study of Mesenchymal Stem Cell-Mediated Mitochondrial Transfer in In Vitro Models of Oxidant-Mediated Airway Epithelial and Smooth Muscle Cell Injury., Methods Mol Biol, Vol:2269, Pages:93-105
et al., 2020, Mitochondrial dysfunction in airways and quadriceps muscle of patients with Chronic Obstructive Pulmonary Disease, Respiratory Research, Vol:21, ISSN:1465-9921
et al., 2020, Role of metabolic reprogramming in pulmonary innate immunity and Its impact on lung diseases, Journal of Innate Immunity, Vol:12, ISSN:1662-811X, Pages:1-16
et al., 2019, REGULATION OF MITOCHONDRIAL TRANSFER BETWEEN AIRWAY SMOOTH MUSCLE CELLS (ASMCS): RELEVANCE TO COPD, Winter Meeting of the British-Thoracic-Society, BMJ PUBLISHING GROUP, Pages:A48-A49, ISSN:0040-6376
et al., 2019, Regulation of mitochondrial transfer between airway smooth muscle cells: relevance to COPD, International Congress of the European-Respiratory-Society (ERS), EUROPEAN RESPIRATORY SOC JOURNALS LTD, ISSN:0903-1936