Dr Bhavsar has established himself as a fully independent researcher within the National Heart and Lung Institute and his research focuses on the mechanisms underlying relative steroid insensitivity in severe asthma and Chornic Obstructive Pulmonary Disease (COPD). Dr Bhavsar has gained an international reputation and visibility within the field of severe asthma. For example, he has recently been invited to visit the Guangzhou Institute of Respiratory Disease, China to present an overview his research and discuss co-operation on mechanisms of severe asthma. Dr Bhavsar has also developed extremely good relationships with the pharmaceutical industry, notably GlaxoSmithKline and Merck Corporation who have provided funding for research and have extended invitations to present at relevant workshops and symposia and has been asked to contribute Medical Scientific Liaison literature explaining the mechanisms of action identified from his research on newly licensed drugs. Dr Bhavsar is a regular chair and facilitator for symposia, poster discussion sessions and thematic poster sessions at the International Conferences of the American Thoracic Society and at the European Respiratory Society.
Dr Bhavsar has demonstrated his research expertise through the publication of a number of significant research papers as lead author in top respiratory journals such as American Journal of Respiratory and Critical Care Medicine, Journal of Allergy and Clinical Immunology and Thorax. He has also been successful in securing considerable research funding from the pharmaceutical industry, as well as the Research Councils and other charitable sources. He has recently been invited to become an Investigator at the MRC Asthma-UK Centre in Allergic Mechanisms of Asthma.
Dr Bhavsar has recently reported a new mechanism for corticosteroid insensitivity specific to the airway smooth muscle (ASM) of patients with severe asthma that involves impaired nuclear translocation of the glucocorticoid receptor. It is this observation which provides the basis of his ongoing basic research of corticosteroid insensitivity in severe asthma. His most recent collaborative research with Pharma identified molecular interaction between LABA and LAMA, a study which is unique, world leading and complements clinical trial findings assessing new bronchodilatory therapies for COPD and asthma.
Dr Bhavsar was awarded his PhD from the University of London (NHLI) in 1995, studying the molecular mechanisms underlying cardiac-specific gene regulation, under the supervision of Drs Paul Barton and Nigel Brand in the department of Cardiothoracic Surgery headed by Professor Sir Magdi Yacoub FRS. Dr Bhavsar became a Principal Investigator 18 months into his post-doctoral career with the award of a project grant from The British Heart Foundation. In 2001 Dr Bhavsar was promoted to Research Lecturer and worked on the ‘bridge to recovery’ programme, designed by Prof. Yacoub, seeking alternative surgical treatments for end-stage heart failure. In recognition of his research, and other contributions to the College including undergraduate and post-graduate student supervision and teaching, Dr Bhavsar was been promoted to Senior Research Fellow in September 2015.
In addition to his academic work, Dr Bhavsar is also a reviewer for major funding bodies and international basic science and clinical journals.
Recent publications and media coverage
et al., 2022, Favipiravir in patients hospitalised with COVID-19 (PIONEER trial): a multicentre, open-label, phase 3, randomised controlled trial of early intervention versus standard care., Lancet Respir Med
et al., 2022, Active air monitoring for understanding the ventilation and infection risks of SARS-CoV-2 transmission in public indoor spaces, Atmosphere, Vol:13, ISSN:2073-4433, Pages:1-24
et al., 2022, Mitochondrial transfer regulates bioenergetics in healthy and COPD airway smooth muscle, American Journal of Respiratory Cell and Molecular Biology, Vol:67, ISSN:1044-1549, Pages:471-481
et al., 2022, Molecular mechanisms of oxidative stress in asthma, Molecular Aspects of Medicine, Vol:85, ISSN:0098-2997
et al., 2022, Clinical and transcriptomic features of persistent exacerbation-prone severe asthma in U-BIOPRED cohort, Clinical and Translational Medicine, Vol:12, ISSN:2001-1326