Publications
103 results found
Saito J, Zhang Q, Hui C, et al., 2013, Sputum hydrogen sulfide as a novel biomarker of obstructive neutrophilic asthma, JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY, Vol: 131, Pages: 232-234, ISSN: 0091-6749
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- Citations: 40
Michaeloudes C, Bhavsar PK, Lam EWF, et al., 2013, Effect Of Tgf-β On Forkhead Box Class O (foxo)-Mediated Signalling In Airway Smooth Muscle Cells, Publisher: AMER THORACIC SOC, ISSN: 1073-449X
Lo C-Y, Michaeloudes C, Bhavsar PK, et al., 2013, Effect Of Dexamethaosne On Circulating Fibrocytes From Severe Asthma Patients, Publisher: AMER THORACIC SOC, ISSN: 1073-449X
Chang PJ, Bhavsar PK, Michaeloudes C, et al., 2012, Corticosteroid insensitivity of chemokine expression in airway smooth muscle of patients with severe asthma., J Allergy Clin Immunol., Vol: 4, Pages: 877-885
Chang P-J, Baker J, Chung KF, et al., 2012, Corticosteroid insensitivity in severe asthma: Impaired nuclear translocation of glucocorticoid receptor in airway smooth muscle cells, Publisher: EUROPEAN RESPIRATORY SOC JOURNALS LTD, ISSN: 0903-1936
Michaeloudes C, Baker J, Bhavsar PK, et al., 2012, Effect of TGF-β on FoxO activity in airway smooth muscle cells, Publisher: EUROPEAN RESPIRATORY SOC JOURNALS LTD, ISSN: 0903-1936
Hui CKM, Perry MM, Bhavsar PK, et al., 2011, HYDROGEN SULFIDE (H2S) IN OXIDATIVE STRESS AND PROLIFERATION OF AIRWAY SMOOTH MUSCLE CELLS (ASMC) IN COPD, RESPIROLOGY, Vol: 16, Pages: 128-128, ISSN: 1323-7799
Zhang Q, Liang Z, Gibeon D, et al., 2011, PRESENCE OF BACTERIA FROM ASTHMATIC AIRWAYS: RELATIONSHIP TO SEVERITY, RESPIROLOGY, Vol: 16, Pages: 220-221, ISSN: 1323-7799
Jouneau S, Khorasani N, De Souza P, et al., 2011, EMMPRIN (CD147) regulation of MMP-9 in bronchial epithelial cells in COPD, RESPIROLOGY, Vol: 16, Pages: 705-712, ISSN: 1323-7799
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- Citations: 32
Li F, Zhang M, Hussain F, et al., 2011, Inhibition of p38 MAPK-dependent bronchial contraction after ozone by corticosteroids, EUROPEAN RESPIRATORY JOURNAL, Vol: 37, Pages: 933-942, ISSN: 0903-1936
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- Citations: 31
Michaeloudes C, Sukkar MB, Khorasani NM, et al., 2011, TGF-β regulates Nox4, MnSOD and catalase expression, and IL-6 release in airway smooth muscle cells, AMERICAN JOURNAL OF PHYSIOLOGY-LUNG CELLULAR AND MOLECULAR PHYSIOLOGY, Vol: 300, Pages: L295-L304, ISSN: 1040-0605
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- Citations: 151
Bhavsar PK, Brand NJ, Felkin LE, et al., 2010, Clenbuterol Induces Cardiac Myocyte Hypertrophy via Paracrine Signalling and Fibroblast-derived IGF-1, JOURNAL OF CARDIOVASCULAR TRANSLATIONAL RESEARCH, Vol: 3, Pages: 688-695, ISSN: 1937-5387
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- Citations: 13
Binia A, Khorasani N, Bhavsar PK, et al., 2010, Chromosome 17q21 SNP and severe asthma, Journal of Human Genetics, Vol: 56, Pages: 97-98, ISSN: 1435-232X
Moffatt MF, Gut IG, Demenais F, et al., 2010, A Large-Scale, Consortium-Based Genomewide Association Study of Asthma, NEW ENGLAND JOURNAL OF MEDICINE, Vol: 363, Pages: 1211-1221, ISSN: 0028-4793
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- Citations: 1474
Bhavsar PK, Levy BD, Hew MJ, et al., 2010, Corticosteroid suppression of lipoxin A<sub>4</sub> and leukotriene B<sub>4</sub> from alveolar macrophages in severe asthma, RESPIRATORY RESEARCH, Vol: 11
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- Citations: 60
Bhavsar P, Khorasani N, Hew M, et al., 2010, Effect of p38 MAPK inhibition on corticosteroid suppression of cytokine release in severe asthma, EUROPEAN RESPIRATORY JOURNAL, Vol: 35, Pages: 750-756, ISSN: 0903-1936
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- Citations: 86
Bhavsar PK, Khorasani N, Johnson M, et al., 2009, Reversal of Relative Corticosteroid Insensitivity in PBMCs from Patients with COPD by p38 MAPK Inhibition., AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE, Vol: 179, ISSN: 1073-449X
Marwick JA, Khorasani N, Bhavsar P, et al., 2009, p38 MAPK, IKK-2 and Oxidative Stress Regulate Histone 3 Serine 10 Phosphorylation in Blood Monocytes and Alveolar Macrophages, AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE, Vol: 179, ISSN: 1073-449X
Bhavsar PK, Khorasani N, Johnson M, et al., 2009, Inhibition of p38 MAPK Activation on Corticosteroid Suppression of Cytokine Release in Severe Asthma, AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE, Vol: 179, ISSN: 1073-449X
Bhavsar P, Hew M, Khorasani N, et al., 2008, Relative corticosteroid insensitivity of alveolar macrophages in severe asthma compared with non-severe asthma, THORAX, Vol: 63, Pages: 784-790, ISSN: 0040-6376
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- Citations: 201
Bhavsar PK, Sukkar MB, Khorasani N, et al., 2008, Glucocorticoid suppression of CX<sub>3</sub>CL1 (fractalkine) by reduced gene promoter recruitment of NF-κB, FASEB JOURNAL, Vol: 22, Pages: 1807-1816, ISSN: 0892-6638
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- Citations: 43
Adcock IM, Ford PA, Bhavsar P, et al., 2008, Steroid resistance in asthma: Mechanisms and treatment options, CURRENT ALLERGY AND ASTHMA REPORTS, Vol: 8, Pages: 171-178, ISSN: 1529-7322
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- Citations: 80
Bhavsar P, Adcock IM, 2008, Molecular Mechanisms of Glucocorticoid Receptor Action, Pages: 1-18
Glucocorticoids are the most effective therapy for the treatment of many chronic inflammatory diseases but they are ineffective in severe asthma and chronic obstructive pulmonary disease (COPD) for example. Glucocorticoids act by binding to and activating specific cytosolic receptors (GR). These receptors then translocate to the nucleus where they regulate gene expression. GR is able to selective repress specific inflammatory genes by differing actions on promoter-specific components of NF-κB and AP-1 activation complexes and also by effects on MAPK pathways. Importantly, these actions are mutually inhibitory. These pleitropic effects of GR may underlie there effectiveness in most patients with airways disease but suggests that abnormal activation of these pathways may result in glucocorticoid refractoriness. Understanding the molecular mechanisms of GR action may lead to the development of new anti-inflammatory drugs or enable clinicians to reverse the relative steroid-insensitivity that is characteristic of severe asthma and COPD for example. © 2008 John Wiley & Sons, Ltd.
Bhavsar P, Ahmad T, Adcock IM, 2008, The role of histone deacetylases in asthma and allergic diseases, JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY, Vol: 121, Pages: 580-584, ISSN: 0091-6749
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- Citations: 96
Adcock IM, Tsaprouni L, Bhavsar P, 2008, Glucocorticoid actions on airway smooth muscle, AIRWAY SMOOTH MUSCLE IN ASTHMA AND COPD: BIOLOGY AND PHARMACOLOGY, Pages: 235-254
Adcock IM, Tsaprouni L, Bhavsar P, et al., 2007, Epigenetic regulation of airway inflammation, CURR OPIN IMMUNOL, Vol: 19, Pages: 694-700, ISSN: 0952-7915
Diverse cellular functions including the regulation of inflammatory gene expression, DNA repair and cell proliferation are regulated by epigenetic changes. Transcriptional co-activators possess intrinsic histone acetyltransferase (HAT) activity, and histone acetylation plays a major role in inflammatory gene expression. Other marks such as histone methylation are also associated with gene induction and gene repression. Recent evidence implicates histone acetylation and methylation as being crucial for the development of tolerance in macrophages and CpG methylation for T regulatory cell development and function. The expression of the enzymes that lay down or remove these epigenetic marks have not been well studied in human airways disease, but reduced HDAC2 expression and activity is reported in lung macrophages, biopsies and blood cells from patients with COPD, severe asthma and smoking asthma. In vitro, inhibitors of histone deacetylases (HDAC) often lead to a further induction of inflammatory gene expression. This is not always the case, however, as HATs and HDACs also target non-histone proteins particularly transcription factors to alter their activity. Furthermore, trichostatin A, an HDAC inhibitor, can reduce inflammation in a murine model of allergic asthma. This effect of HDAC inhibitors may be due to their effects on cell death acting through acetylation of non-histone proteins. The role of epigenetic modifications in inflammatory gene expression and in the control of cell function in the airways is becoming clearer. Targeting specific enzymes involved in this process may lead to new therapeutic agents, in particular, in situations where current anti-inflammatory therapies are currently suboptimal.
Williams AS, Leung S-Y, Nath P, et al., 2007, Role of TLR2, TLR4, and MyD88 in murine ozone-induced airway hyperresponsiveness and neutrophilia, JOURNAL OF APPLIED PHYSIOLOGY, Vol: 103, Pages: 1189-1195, ISSN: 8750-7587
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- Citations: 89
Hew M, Bhavsar P, Torrego A, et al., 2006, Relative corticosteroid insensitivity of peripheral blood mononuclear cells in severe asthma, AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE, Vol: 174, Pages: 134-141, ISSN: 1073-449X
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- Citations: 214
Issa R, Xie S, Lee K-Y, et al., 2006, GRO-α regulation in airway smooth muscle by IL-1β and TNF-α:: role of NF-κB and MAP kinases, AMERICAN JOURNAL OF PHYSIOLOGY-LUNG CELLULAR AND MOLECULAR PHYSIOLOGY, Vol: 291, Pages: L66-L74, ISSN: 1040-0605
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- Citations: 54
Xie SP, Issa RA, Sukkar MB, et al., 2005, Induction and regulation of matrix metalloproteinase-12in human airway smooth muscle cells, Respiratory Research, Vol: 6, ISSN: 1465-993X
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