Imperial College London


Faculty of Natural SciencesDepartment of Life Sciences

Emeritus Reader in Structural Biology



+44 (0)20 7594 7704p.brick




408Sir Ernst Chain BuildingSouth Kensington Campus





The focus of my research is to understand biological processes at the molecular level, and in particular to determine the three‑dimensional structures of individual molecules and macromolecular assemblies using X-ray crystallography.

I teach biochemistry to undergraduates studying for a degree in biology and also lecture on the theory and practice of protein crystallography to graduate students. 



Costa A, Pape T, van Heel M, et al., 2006, Structural basis of the <i>Methanothermobacter thermautotrophicus</i> MCM helicase activity, Nucleic Acids Research, Vol:34, ISSN:0305-1048, Pages:5829-5838

Costa A, Pape T, van Heel M, et al., 2006, Structural studies of the archaeal MCM complex in different functional states, Journal of Structural Biology, Vol:156, ISSN:1047-8477, Pages:210-219

Paraskevopoulou C, Fairhurst SA, Lowe DJ, et al., 2006, The elongator subunit Elp3 contains a Fe<sub>4</sub>S<sub>4</sub> cluster and binds S-adenosylmethionine, Molecular Microbiology, Vol:59, ISSN:0950-382X, Pages:795-806

Birtley JR, Knox SR, Jaulent AM, et al., 2005, Crystal structure of foot-and-mouth disease virus 3C protease, Journal of Biological Chemistry, Vol:280, Pages:11520-11527


Illek S, Brick P, Diehl W, et al., 2006, High power semiconductor disk lasers, 19th Annual Meeting of the IEEE-Lasers-and-Electro-Optics-Society, IEEE, Pages:725-+, ISSN:1092-8081

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