Summary
The focus of my research is to understand biological processes at the molecular level, and in particular to determine the threeâdimensional structures of individual molecules and macromolecular assemblies using X-ray crystallography.
I teach biochemistry to undergraduates studying for a degree in biology and also lecture on the theory and practice of protein crystallography to graduate students.
Publications
Journals
Costa A, Pape T, van Heel M, et al., 2006, Structural basis of the <i>Methanothermobacter thermautotrophicus</i> MCM helicase activity, Nucleic Acids Research, Vol:34, ISSN:0305-1048, Pages:5829-5838
Costa A, Pape T, van Heel M, et al., 2006, Structural studies of the archaeal MCM complex in different functional states, Journal of Structural Biology, Vol:156, ISSN:1047-8477, Pages:210-219
Paraskevopoulou C, Fairhurst SA, Lowe DJ, et al., 2006, The elongator subunit Elp3 contains a Fe<sub>4</sub>S<sub>4</sub> cluster and binds S-adenosylmethionine, Molecular Microbiology, Vol:59, ISSN:0950-382X, Pages:795-806
Birtley JR, Knox SR, Jaulent AM, et al., 2005, Crystal structure of foot-and-mouth disease virus 3C protease, Journal of Biological Chemistry, Vol:280, Pages:11520-11527
Conference
Illek S, Brick P, Diehl W, et al., 2006, High power semiconductor disk lasers, 19th Annual Meeting of the IEEE-Lasers-and-Electro-Optics-Society, IEEE, Pages:725-+, ISSN:1092-8081