Imperial College London
Dr Peter Brick

DrPeterBrick

Faculty of Natural Sciences, Department of Life Sciences

Emeritus Reader in Structural Biology
 
 
 
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Contact

 

+44 (0)20 7594 7704p.brick

 
 
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Location

 

408Sir Ernst Chain BuildingSouth Kensington Campus

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Summary

 

Publications

Publication Type
Year
to

62 results found

Rowsell S, Pauptit RA, Tucker AD, Melton RG, Blow DM, Brick Pet al., 1997, Crystal structure of carboxypeptidase G(2), a bacterial enzyme with applications in cancer therapy, STRUCTURE, Vol: 5, Pages: 337-347, ISSN: 0969-2126

Journal article

Conti E, Lloyd LF, Akins J, Franks NP, Brick Pet al., 1996, Crystallization and preliminary diffraction studies of firefly luciferase from Photinus pyralis, ACTA CRYSTALLOGRAPHICA SECTION D-BIOLOGICAL CRYSTALLOGRAPHY, Vol: 52, Pages: 876-878, ISSN: 0907-4449

Journal article

Conti E, Franks NP, Brick P, 1996, Crystal structure of firefly luciferase throws light on a superfamily of adenylate-forming enzymes, STRUCTURE, Vol: 4, Pages: 287-298, ISSN: 0969-2126

Journal article

Shingleton WD, Hodges DJ, Brick P, Cawston TEet al., 1996, Collagenase: A key enzyme in collagen turnover, BIOCHEMISTRY AND CELL BIOLOGY, Vol: 74, Pages: 759-775, ISSN: 0829-8211

Journal article

Izumi Y, Yoshida T, Hagishita T, Tanaka Y, Mitsunaga T, Ohshiro T, Tanabe T, Miyata A, Yokoyama C, Goldberg JD, Brick Pet al., 1996, Structure and function of the serine pathway enzymes in Hyphomicrobium, 8th International Symposium on Microbial Growth on C(1) Compounds, Publisher: KLUWER ACADEMIC PUBL, Pages: 25-32

Conference paper

LI J, BRICK P, OHARE MC, SKARZYNSKI T, LLOYD LF, CURRY VA, CLARK IM, BIGG HF, HAZLEMAN BL, CAWSTON TE, BLOW DMet al., 1995, STRUCTURE OF FULL-LENGTH PORCINE SYNOVIAL COLLAGENASE REVEALS A C-TERMINAL DOMAIN-CONTAINING A CALCIUM-LINKED, 4-BLADED BETA-PROPELLER, STRUCTURE, Vol: 3, Pages: 541-549, ISSN: 0969-2126

Journal article

Onesti S, Miller AD, Brick P, 1995, The crystal structure of the lysyl-tRNA synthetase (LysU) from Escherichia-coli, Structure, Vol: 3, Pages: 163-176

Journal article

ONESTI S, THEOCLITOU ME, WITTUNG L, MILLER AD, PLATEAU P, BLANQUET S, BRICK P, PERNILLA Eet al., 1994, CRYSTALLIZATION AND PRELIMINARY DIFFRACTION STUDIES OF ESCHERICHIA-COLI LYSYL-TRANSFER-RNA SYNTHETASE (LYSU), JOURNAL OF MOLECULAR BIOLOGY, Vol: 243, Pages: 123-125, ISSN: 0022-2836

Journal article

Goldberg JD, Yoshida T, Brick P, 1994, Crystal structure of a NAD-dependent D-glycerate dehydrogenase at 2.4 A resolution., J Mol Biol, Vol: 236, Pages: 1123-1140, ISSN: 0022-2836

D-Glycerate dehydrogenase (GDH) catalyzes the NADH-linked reduction of hydroxypyruvate to D-glycerate. GDH is a member of a family of NAD-dependent dehydrogenases that is characterized by a specificity for the D-isomer of the hydroxyacid substrate. The crystal structure of the apoenzyme form of GDH from Hyphomicrobium methylovorum has been determined by the method of isomorphous replacement and refined at 2.4 A resolution using a restrained least-squares method. The crystallographic R-factor is 19.4% for all 24,553 measured reflections between 10.0 and 2.4 A resolution. The GDH molecule is a symmetrical dimer composed of subunits of molecular mass 38,000, and shares significant structural homology with another NAD-dependent enzyme, formate dehydrogenase. The GDH subunit consists of two structurally similar domains that are approximately related to each other by 2-fold symmetry. The domains are separated by a deep cleft that forms the putative NAD and substrate binding sites. One of the domains has been identified as the NAD-binding domain based on its close structural similarity to the NAD-binding domains of other NAD-dependent dehydrogenases. The topology of the second domain is different from that found in the various catalytic domains of other dehydrogenases. A model of a ternary complex of GDH has been built in which putative catalytic residues are identified based on sequence homology between the D-isomer specific dehydrogenases. A structural comparison between GDH and L-lactate dehydrogenase indicates a convergence of active site residues and geometries for these two enzymes. The reactions catalyzed are chemically equivalent but of opposing stereospecificity. A hypothesis is presented to explain how the two enzymes may exploit the same coenzyme stereochemistry and a similar spatial arrangement of catalytic residues to carry out reactions that proceed to opposite enantiomers.

Journal article

GOLDBERG JD, YOSHIDA T, BRICK P, 1994, CRYSTAL-STRUCTURE OF A NAD-DEPENDENT D-GLYCERATE DEHYDROGENASE AT 2-CENTER-DOT-4-ANGSTROM RESOLUTION, JOURNAL OF MOLECULAR BIOLOGY, Vol: 236, Pages: 1123-1140, ISSN: 0022-2836

Journal article

Vrielink A, Li JY, Brick P, Blow Det al., 1994, The crystal structure of cholesterol oxidase. Mechanistic implications for fad dependent alcohol oxidation., 11th International Symposium on Flavins and Flavoproteins, Publisher: WALTER DE GRUYTER, Pages: 175-184

Conference paper

LI JY, VRIELINK A, BRICK P, BLOW DMet al., 1993, CRYSTAL-STRUCTURE OF CHOLESTEROL OXIDASE COMPLEXED WITH A STEROID SUBSTRATE - IMPLICATIONS FOR FLAVIN ADENINE-DINUCLEOTIDE DEPENDENT ALCOHOL OXIDASES, BIOCHEMISTRY, Vol: 32, Pages: 11507-11515, ISSN: 0006-2960

Journal article

BLOW DM, BRICK P, COLLYER CA, GOLDBERG JD, SMART Oet al., 1992, CONVENTIONAL X-RAY-DIFFRACTION APPROACHES TO THE STUDY OF ENZYME MECHANISM - SERINE PROTEINASES, AMINOACYL-TRANSFER RNA-SYNTHETASES AND XYLOSE ISOMERASE, PHILOSOPHICAL TRANSACTIONS OF THE ROYAL SOCIETY OF LONDON SERIES A-MATHEMATICAL PHYSICAL AND ENGINEERING SCIENCES, Vol: 340, Pages: 311-321, ISSN: 0962-8428

Journal article

LLOYD LF, BRICK P, BLOW DM, LOU MZet al., 1992, CRYSTALLIZATION STUDIES ON HIV-1 REVERSE-TRANSCRIPTASE, 4TH INTERNATIONAL SYMP ON CRYSTAL GROWTH OF BIOLOGICAL MACROMOLECULES - A FEBS ADVANCED LECTURE COURSE 1991, Publisher: ELSEVIER SCIENCE BV, Pages: 355-359, ISSN: 0022-0248

Conference paper

GOLDBERG JD, BRICK P, YOSHIDA T, MITSUNAGA T, OSHIRO T, SHIMAO M, IZUMI Yet al., 1992, CRYSTALLIZATION AND PRELIMINARY DIFFRACTION STUDIES OF HYDROXYPYRUVATE REDUCTASE (D-GLYCERATE DEHYDROGENASE) FROM HYPHOMICROBIUM-METHYLOVORUM, JOURNAL OF MOLECULAR BIOLOGY, Vol: 225, Pages: 909-911, ISSN: 0022-2836

Journal article

VRIELINK A, LI JY, BRICK P, BLOW Det al., 1992, STRUCTURE AND MECHANISM OF CHOLESTEROL OXIDASE, 2ND INTERNATIONAL CONF ON CHEMICAL AND BIOCHEMICAL PROBLEMS IN MOLECULAR RECOGNITION, Publisher: ROYAL SOC CHEMISTRY, Pages: 83-93, ISSN: 0260-6291

Conference paper

LLOYD LF, BRICK P, LOU MZ, CHAYEN NE, BLOW DMet al., 1991, MANY CRYSTAL FORMS OF HUMAN-IMMUNODEFICIENCY-VIRUS REVERSE-TRANSCRIPTASE, JOURNAL OF MOLECULAR BIOLOGY, Vol: 217, Pages: 19-22, ISSN: 0022-2836

Journal article

ONESTI S, BRICK P, BLOW DM, 1991, CRYSTAL-STRUCTURE OF A KUNITZ-TYPE TRYPSIN-INHIBITOR FROM ERYTHRINA-CAFFRA SEEDS, JOURNAL OF MOLECULAR BIOLOGY, Vol: 217, Pages: 153-176, ISSN: 0022-2836

Journal article

ONESTI S, LLOYD LF, BRICK P, BLOW DMet al., 1989, CRYSTALLIZATION AND PRELIMINARY DIFFRACTION STUDIES OF ERYTHRINA TRYPSIN-INHIBITOR, JOURNAL OF MOLECULAR BIOLOGY, Vol: 210, Pages: 241-242, ISSN: 0022-2836

Journal article

BRICK P, BHAT TN, BLOW DM, 1989, STRUCTURE OF TYROSYL TRANSFER-RNA SYNTHETASE REFINED AT 2.3-A RESOLUTION - INTERACTION OF THE ENZYME WITH THE TYROSYL ADENYLATE INTERMEDIATE, JOURNAL OF MOLECULAR BIOLOGY, Vol: 208, Pages: 83-98, ISSN: 0022-2836

Journal article

BROWN KA, BRICK P, BLOW DM, 1987, STRUCTURE OF A MUTANT OF TYROSYL-TRANSFER RNA-SYNTHETASE WITH ENHANCED CATALYTIC PROPERTIES, NATURE, Vol: 326, Pages: 416-418, ISSN: 0028-0836

Journal article

BRICK P, BLOW DM, 1987, CRYSTAL-STRUCTURE OF A DELETION MUTANT OF A TYROSYL-TRANSFER RNA-SYNTHETASE COMPLEXED WITH TYROSINE, JOURNAL OF MOLECULAR BIOLOGY, Vol: 194, Pages: 287-297, ISSN: 0022-2836

Journal article

AKINS J, BRICK P, JONES HB, HIRAYAMA N, SHAW PC, BLOW DMet al., 1986, THE CRYSTALLIZATION OF GLUCOSE-ISOMERASE FROM ARTHROBACTER-B3728, BIOCHIMICA ET BIOPHYSICA ACTA, Vol: 874, Pages: 375-377, ISSN: 0006-3002

Journal article

STEITZ TA, OLLIS D, BRICK P, 1985, STRUCTURE OF THE LARGE FRAGMENT OF ESCHERICHIA-COLI DNA-POLYMERASE-I COMPLEXED WITH DTMP, FEDERATION PROCEEDINGS, Vol: 44, Pages: R8-R8, ISSN: 0014-9446

Journal article

FERSHT AR, SHI JP, KNILLJONES J, LOWE DM, WILKINSON AJ, BLOW DM, BRICK P, CARTER P, WAYE MMY, WINTER Get al., 1985, HYDROGEN-BONDING AND BIOLOGICAL SPECIFICITY ANALYZED BY PROTEIN ENGINEERING, NATURE, Vol: 314, Pages: 235-238, ISSN: 0028-0836

Journal article

OLLIS DL, BRICK P, HAMLIN R, XUONG NG, STEITZ TAet al., 1985, STRUCTURE OF LARGE FRAGMENT OF ESCHERICHIA-COLI DNA-POLYMERASE-I COMPLEXED WITH DTMP, NATURE, Vol: 313, Pages: 762-766, ISSN: 0028-0836

Journal article

OLLIS D, BRICK P, HAMLIN R, XUONG NG, STEITZ TAet al., 1984, STRUCTURE OF THE LARGE FRAGMENT OF ESCHERICHIA-COLI DNA-POLYMERASE-I COMPLEXED WITH DCMP, ACTA CRYSTALLOGRAPHICA SECTION A, Vol: 40, Pages: C47-C47, ISSN: 0108-7673

Journal article

MONTEILHET C, BLOW DM, BRICK P, 1984, INTERACTION OF CRYSTALLINE TYROSYL-TRANSFER RNA-SYNTHETASE WITH ADENOSINE, ADENOSINE-MONOPHOSPHATE, ADENOSINE-TRIPHOSPHATE AND PYROPHOSPHATE IN THE PRESENCE OF TYROSINOL, JOURNAL OF MOLECULAR BIOLOGY, Vol: 173, Pages: 477-485, ISSN: 0022-2836

Journal article

STEITZ TA, WEBER IT, OLLIS D, BRICK Pet al., 1983, CRYSTALLOGRAPHIC STUDIES OF PROTEIN-NUCLEIC ACID INTERACTION - CATABOLITE GENE ACTIVATOR PROTEIN AND THE LARGE FRAGMENT OF DNA-POLYMERASE-I, JOURNAL OF BIOMOLECULAR STRUCTURE & DYNAMICS, Vol: 1, Pages: 1023-1037, ISSN: 0739-1102

Journal article

BRICK P, OLLIS D, STEITZ TA, 1983, CRYSTALLIZATION AND 7-A RESOLUTION ELECTRON-DENSITY MAP OF THE LARGE FRAGMENT OF ESCHERICHIA-COLI DNA-POLYMERASE-I, JOURNAL OF MOLECULAR BIOLOGY, Vol: 166, Pages: 453-456, ISSN: 0022-2836

Journal article

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