Imperial College London
Alternate

Professor Peter GJ Burney MA MD FRCP FFPHM FMedSci

Faculty of Medicine, National Heart & Lung Institute

Emeritus Professor of Respiratory Epidemiology
 
 
 
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Contact

 

+44 (0)20 7594 7941p.burney

 
 
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Location

 

07Emmanuel Kaye BuildingRoyal Brompton Campus

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Summary

 

Publications

Citation

BibTex format

@article{Nightingale:2019:10.1164/rccm.201805-0936OC,
author = {Nightingale, R and Lesosky, M and Flitz, G and Rylance, SJ and Meghji, J and Burney, P and Balmes, J and Mortimer, K},
doi = {10.1164/rccm.201805-0936OC},
journal = {American Journal of Respiratory and Critical Care Medicine},
pages = {613--621},
title = {Non-communicable respiratory disease and air pollution exposure in Malawi (CAPS). A cross-sectional study},
url = {http://dx.doi.org/10.1164/rccm.201805-0936OC},
volume = {199},
year = {2019}
}
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RIS format (EndNote, RefMan)

TY  - JOUR
AB  - Background Non-communicable respiratory diseases and exposure to air pollution are thought to be important contributors to morbidity and mortality in sub-Saharan African adults. Methods We did a cross-sectional study among adults in communities participating in a randomised controlled trial of a cleaner-burning biomass-fuelled cookstove intervention (CAPS) in rural Malawi. We assessed chronic respiratory symptoms, spirometric abnormalities, personal exposure to air pollution (fine particulate matter (PM2.5) and carbon monoxide (CO)). Weighted prevalence estimates were calculated; multivariable and intention-to-treat analyses were done. Results 1481 participants (mean (SD)) age 43·8 (17·8)) 57% female) were recruited. The prevalence of chronic respiratory symptoms, spirometric obstruction and restriction were 13·6% (95% CI:11.9-15.4), 8·7% (95% CI:7·0-10·7) and 34·8% (95% CI:31·7-38·0), respectively. Median 48-hour personal PM2.5 and CO exposures were 71·0 μg/m3 (IQR:44·6-119·2) and 1·23 ppm (IQR:0·79-1·93), respectively. Chronic respiratory symptoms were associated with current/ex-smoking (OR=1·59 (95% CI:1·05-2·39)), previous TB (OR=2·50 (95% CI:1·04-15·58)) and CO exposure (OR=1·46 (95% CI:1·04-2·05)). Exposure to PM2.5 was not associated with any demographic, clinical or spirometric characteristics. There was no effect of the CAPS intervention on any of the secondary trial outcomes. Conclusion The burden of chronic respiratory symptoms, abnormal spirometry and air pollution exposures in adults in rural Malawi is of considerable potential public health importance. We found little evidence that air pollution exposures were associated with chronic respiratory symptoms or spirometric abnormalities and no evidence that the CAPS intervention had effects on the secondary trial outcomes. More effective
AU  - Nightingale,R
AU  - Lesosky,M
AU  - Flitz,G
AU  - Rylance,SJ
AU  - Meghji,J
AU  - Burney,P
AU  - Balmes,J
AU  - Mortimer,K
DO  - 10.1164/rccm.201805-0936OC
EP  - 621
PY  - 2019///
SN  - 1073-449X
SP  - 613
TI  - Non-communicable respiratory disease and air pollution exposure in Malawi (CAPS). A cross-sectional study
T2  - American Journal of Respiratory and Critical Care Medicine
UR  - http://dx.doi.org/10.1164/rccm.201805-0936OC
UR  - https://www.ncbi.nlm.nih.gov/pubmed/30141966
UR  - http://hdl.handle.net/10044/1/63475
VL  - 199
ER  -
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