Imperial College London
Alternate

Professor Peter GJ Burney MA MD FRCP FFPHM FMedSci

Faculty of Medicine, National Heart & Lung Institute

Emeritus Professor of Respiratory Epidemiology
 
 
 
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Contact

 

+44 (0)20 7594 7941p.burney

 
 
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Location

 

07Emmanuel Kaye BuildingRoyal Brompton Campus

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Summary

 

Publications

Citation

BibTex format

@article{Burney:2021:10.1164/rccm.202005-1990OC,
author = {Burney, P and Patel, J and Minelli, C and Gnatiuc, L and Amaral, A and Kocabas, A and Cherkaski, H and Gulsvik, A and Nielsen, R and Bateman, E and Jithoo, A and Mortimer, K and Sooronbaev, T and Lawin, H and Nejjari, C and Elbiaze, M and El, Rhazi K and Zheng, J-P and Ran, P and Welte, T and Obaseki, D and Erhabor, G and Elsony, A and Osman, N and Ahmed, R and Nizankowska, -Mogilnicka E and Mejza, F and Mannino, D and Barbara, C and Wouters, E and Idolor, L and Loh, L-C and Rashid, A and Juvekar, S and Gislason, T and Al, Ghobain M and Studnicka, M and Harrabi, I and Denguezli, M and Koul, P and Jenkins, C and Marks, G and Jogi, R and Hafizi, H and Janson, C and Tan, W and Aquart-Stewart, A and Mbatchou, B and Nafees, A and Gunasekera, K and Seemungal, T and Mahesh, PA and Enright, P and Vollmer, W and Blangiardo, M and Elfadaly, F and Buist, AS},
doi = {10.1164/rccm.202005-1990OC},
journal = {American Journal of Respiratory and Critical Care Medicine},
pages = {1353--1365},
title = {Prevalence and population attributable risk for chronic airflow obstruction in a large multinational study},
url = {http://dx.doi.org/10.1164/rccm.202005-1990OC},
volume = {203},
year = {2021}
}
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RIS format (EndNote, RefMan)

TY  - JOUR
AB  - Rationale: The Global Burden of Disease programme identified smoking, and ambient and household air pollution as the main drivers of death and disability from Chronic Obstructive Pulmonary Disease (COPD). Objective: To estimate the attributable risk of chronic airflow obstruction (CAO), a quantifiable characteristic of COPD, due to several risk factors. Methods: The Burden of Obstructive Lung Disease study is a cross-sectional study of adults, aged≥40, in a globally distributed sample of 41 urban and rural sites. Based on data from 28,459 participants, we estimated the prevalence of CAO, defined as a post-bronchodilator one-second forced expiratory volume to forced vital capacity ratio < lower limit of normal, and the relative risks associated with different risk factors. Local RR were estimated using a Bayesian hierarchical model borrowing information from across sites. From these RR and the prevalence of risk factors, we estimated local Population Attributable Risks (PAR). Measurements and Main Results: Mean prevalence of CAO was 11.2% in men and 8.6% in women. Mean PAR for smoking was 5.1% in men and 2.2% in women. The next most influential risk factors were poor education levels, working in a dusty job for ≥10 years, low body mass index (BMI), and a history of tuberculosis. The risk of CAO attributable to the different risk factors varied across sites. Conclusions: While smoking remains the most important risk factor for CAO, in some areas poor education, low BMI and passive smoking are of greater importance. Dusty occupations and tuberculosis are important risk factors at some sites.
AU  - Burney,P
AU  - Patel,J
AU  - Minelli,C
AU  - Gnatiuc,L
AU  - Amaral,A
AU  - Kocabas,A
AU  - Cherkaski,H
AU  - Gulsvik,A
AU  - Nielsen,R
AU  - Bateman,E
AU  - Jithoo,A
AU  - Mortimer,K
AU  - Sooronbaev,T
AU  - Lawin,H
AU  - Nejjari,C
AU  - Elbiaze,M
AU  - El,Rhazi K
AU  - Zheng,J-P
AU  - Ran,P
AU  - Welte,T
AU  - Obaseki,D
AU  - Erhabor,G
AU  - Elsony,A
AU  - Osman,N
AU  - Ahmed,R
AU  - Nizankowska,-Mogilnicka E
AU  - Mejza,F
AU  - Mannino,D
AU  - Barbara,C
AU  - Wouters,E
AU  - Idolor,L
AU  - Loh,L-C
AU  - Rashid,A
AU  - Juvekar,S
AU  - Gislason,T
AU  - Al,Ghobain M
AU  - Studnicka,M
AU  - Harrabi,I
AU  - Denguezli,M
AU  - Koul,P
AU  - Jenkins,C
AU  - Marks,G
AU  - Jogi,R
AU  - Hafizi,H
AU  - Janson,C
AU  - Tan,W
AU  - Aquart-Stewart,A
AU  - Mbatchou,B
AU  - Nafees,A
AU  - Gunasekera,K
AU  - Seemungal,T
AU  - Mahesh,PA
AU  - Enright,P
AU  - Vollmer,W
AU  - Blangiardo,M
AU  - Elfadaly,F
AU  - Buist,AS
DO  - 10.1164/rccm.202005-1990OC
EP  - 1365
PY  - 2021///
SN  - 1073-449X
SP  - 1353
TI  - Prevalence and population attributable risk for chronic airflow obstruction in a large multinational study
T2  - American Journal of Respiratory and Critical Care Medicine
UR  - http://dx.doi.org/10.1164/rccm.202005-1990OC
UR  - http://hdl.handle.net/10044/1/85369
VL  - 203
ER  -
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