Imperial College London
Alternate

Professor Patrice D. Cani

Faculty of Medicine, Department of Metabolism, Digestion and Reproduction

Visiting Professor
 
 
 
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Contact

 

p.cani Website CV

 
 
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Location

 

Sir Alexander Fleming BuildingSouth Kensington Campus

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Summary

 

Publications

Citation

BibTex format

@article{Tilg:2016:10.1136/gutjnl-2016-312729,
author = {Tilg, H and Cani, PD and Mayer, EA},
doi = {10.1136/gutjnl-2016-312729},
journal = {Gut},
pages = {2035--2044},
title = {Gut microbiome and liver diseases.},
url = {http://dx.doi.org/10.1136/gutjnl-2016-312729},
volume = {65},
year = {2016}
}
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RIS format (EndNote, RefMan)

TY  - JOUR
AB  - The gut microbiota has recently evolved as a new important player in the pathophysiology of many intestinal and extraintestinal diseases. The liver is the organ which is in closest contact with the intestinal tract, and is exposed to a substantial amount of bacterial components and metabolites. Various liver disorders such as alcoholic liver disease, non-alcoholic liver disease and primary sclerosing cholangitis have been associated with an altered microbiome. This dysbiosis may influence the degree of hepatic steatosis, inflammation and fibrosis through multiple interactions with the host's immune system and other cell types. Whereas few results from clinical metagenomic studies in liver disease are available, evidence is accumulating that in liver cirrhosis an oral microbiome is overrepresented in the lower intestinal tract, potentially contributing to disease process and severity. A major role for the gut microbiota in liver disorders is also supported by the accumulating evidence that several complications of severe liver disease such as hepatic encephalopathy are efficiently treated by various prebiotics, probiotics and antibiotics. A better understanding of the gut microbiota and its components in liver diseases might provide a more complete picture of these complex disorders and also form the basis for novel therapies.
AU  - Tilg,H
AU  - Cani,PD
AU  - Mayer,EA
DO  - 10.1136/gutjnl-2016-312729
EP  - 2044
PY  - 2016///
SP  - 2035
TI  - Gut microbiome and liver diseases.
T2  - Gut
UR  - http://dx.doi.org/10.1136/gutjnl-2016-312729
UR  - https://www.ncbi.nlm.nih.gov/pubmed/27802157
VL  - 65
ER  -
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