Imperial College London
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Professor Peter Cherepanov

Faculty of Medicine, Department of Infectious Disease

Professor of Molecular Virology
 
 
 
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Contact

 

p.cherepanov

 
 
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Location

 

Norfolk PlaceSt Mary's Campus

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Summary

 

Publications

Citation

BibTex format

@article{Maertens:2022:10.1038/s41579-021-00586-9,
author = {Maertens, GN and Engelman, AN and Cherepanov, P},
doi = {10.1038/s41579-021-00586-9},
journal = {Nature Reviews Microbiology},
pages = {20--34},
title = {Structure and function of retroviral integrase},
url = {http://dx.doi.org/10.1038/s41579-021-00586-9},
volume = {20},
year = {2022}
}
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RIS format (EndNote, RefMan)

TY  - JOUR
AB  - A hallmark of retroviral replication is establishment of the proviral state, wherein a DNA copy of the viral RNA genome is stably incorporated into a host cell chromosome. Integrase is the viral enzyme responsible for the catalytic steps involved in this process, and integrase strand transfer inhibitors are widely used to treat people living with HIV. Over the past decade, a series of X-ray crystallography and cryogenic electron microscopy studies have revealed the structural basis of retroviral DNA integration. A variable number of integrase molecules congregate on viral DNA ends to assemble a conserved intasome core machine that facilitates integration. The structures additionally informed on the modes of integrase inhibitor action and the means by which HIV acquires drug resistance. Recent years have witnessed the development of allosteric integrase inhibitors, a highly promising class of small molecules that antagonize viral morphogenesis. In this Review, we explore recent insights into the organization and mechanism of the retroviral integration machinery and highlight open questions as well as new directions in the field.
AU  - Maertens,GN
AU  - Engelman,AN
AU  - Cherepanov,P
DO  - 10.1038/s41579-021-00586-9
EP  - 34
PY  - 2022///
SN  - 1740-1526
SP  - 20
TI  - Structure and function of retroviral integrase
T2  - Nature Reviews Microbiology
UR  - http://dx.doi.org/10.1038/s41579-021-00586-9
UR  - https://www.ncbi.nlm.nih.gov/pubmed/34244677
UR  - http://hdl.handle.net/10044/1/90396
VL  - 20
ER  -
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