Imperial College London
Portrait Picture

DrPaulaCunnea

Faculty of Medicine, Department of Surgery & Cancer

Advanced Research Fellow
 
 
 
//

Contact

 

+44 (0)20 7594 1548p.cunnea

 
 
//

Location

 

Institute of Reproductive and Developmental BiologyHammersmith Campus

//

Summary

 

Publications

Citation

BibTex format

@article{Cunnea:2021:10.3390/cancers13133349,
author = {Cunnea, P and Fotopoulou, C and Ploski, J and Trillsch, F and Mahner, S and Kessler, M},
doi = {10.3390/cancers13133349},
journal = {Cancers},
title = {Changes in stem cell regulation and epithelial organisation during carcinogenesis and disease progression in gynaecological malignancies},
url = {http://dx.doi.org/10.3390/cancers13133349},
volume = {13},
year = {2021}
}
Download

RIS format (EndNote, RefMan)

TY  - JOUR
AB  - Gynaecological malignancies represent a heterogeneous group of neoplasms with vastly different aetiology, risk factors, molecular drivers, and disease outcomes. From HPV-driven cervical cancer where early screening and molecular diagnostics efficiently reduced the number of advanced-stage diagnosis, prevalent and relatively well-treated endometrial cancers, to highly aggressive and mostly lethal high-grade serous ovarian cancer, malignancies of the female genital tract have unique presentations and distinct cell biology features. Recent discoveries of stem cell regulatory mechanisms, development of organoid cultures, and NGS analysis have provided valuable insights into the basic biology of these cancers that could help advance new-targeted therapeutic approaches. This review revisits new findings on stemness and differentiation, considering main challenges and open questions. We focus on the role of stem cell niche and tumour microenvironment in early and metastatic stages of the disease progression and highlight the potential of patient-derived organoid models to study key events in tumour evolution, the appearance of resistance mechanisms, and as screening tools to enable personalisation of drug treatments.
AU  - Cunnea,P
AU  - Fotopoulou,C
AU  - Ploski,J
AU  - Trillsch,F
AU  - Mahner,S
AU  - Kessler,M
DO  - 10.3390/cancers13133349
PY  - 2021///
SN  - 2072-6694
TI  - Changes in stem cell regulation and epithelial organisation during carcinogenesis and disease progression in gynaecological malignancies
T2  - Cancers
UR  - http://dx.doi.org/10.3390/cancers13133349
UR  - http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcApp=PARTNER_APP&SrcAuth=LinksAMR&KeyUT=WOS:000671020900001&DestLinkType=FullRecord&DestApp=ALL_WOS&UsrCustomerID=1ba7043ffcc86c417c072aa74d649202
UR  - https://www.mdpi.com/2072-6694/13/13/3349
UR  - http://hdl.handle.net/10044/1/93909
VL  - 13
ER  -
Download