Imperial College London

DrPiersDaubeney

Faculty of MedicineNational Heart & Lung Institute

Professor of Practice (Paediatric Cardiology)
 
 
 
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Contact

 

+44 (0)20 7351 8430p.daubeney

 
 
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Location

 

Royal BromptonRoyal Brompton Campus

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Summary

 

Publications

Citation

BibTex format

@article{Eichhorn:2019:10.1186/s13256-019-2096-6,
author = {Eichhorn, C and Voges, I and Daubeney, PEF},
doi = {10.1186/s13256-019-2096-6},
journal = {Journal of Medical Case Reports},
title = {Out-of-hospital cardiac arrest and survival in a patient with Noonan syndrome and multiple lentigines: a case report},
url = {http://dx.doi.org/10.1186/s13256-019-2096-6},
volume = {13},
year = {2019}
}

RIS format (EndNote, RefMan)

TY  - JOUR
AB - BACKGROUND: A 9-year-old Arabic boy attending middle school presented with an out-of-hospital cardiac arrest due to ventricular fibrillation recorded by Holter electrocardiographic monitoring. He had a background history of Noonan syndrome with multiple lentigines (also known as LEOPARD syndrome), a rare condition of autosomal dominant inheritance with approximately 200 cases reported worldwide. CASE PRESENTATION: Apart from characteristic features, the boy was known to have asymmetric septal hypertrophy with a maximum wall thickness of 24 mm measured by cardiovascular magnetic resonance imaging. A day prior to the event, he attended cardiology follow-up at our institution, and Holter monitoring was commenced. Following cardiopulmonary resuscitation by bystanders and paramedics, he reverted back into sinus rhythm after a total downtime of 24 min. He was initially treated in the intensive care unit and underwent implantable cardioverter defibrillator implantation. He has made a full recovery and remains at the top of his class. CONCLUSION: This case demonstrates that sudden cardiac arrest in patients with secondary forms of hypertrophic cardiomyopathy is not necessarily protected by apparently favorable phenotypes and that events may be preceded by non-sustained ventricular tachycardia observed by Holter monitoring. Implantable cardioverter defibrillator implantation plays a critical role in both primary and secondary prevention in patients at high risk of out-of-hospital cardiac arrest.
AU - Eichhorn,C
AU - Voges,I
AU - Daubeney,PEF
DO - 10.1186/s13256-019-2096-6
PY - 2019///
SN - 1752-1947
TI - Out-of-hospital cardiac arrest and survival in a patient with Noonan syndrome and multiple lentigines: a case report
T2 - Journal of Medical Case Reports
UR - http://dx.doi.org/10.1186/s13256-019-2096-6
UR - https://www.ncbi.nlm.nih.gov/pubmed/31208451
UR - http://hdl.handle.net/10044/1/71088
VL - 13
ER -