Imperial College London

ProfessorPaulElkington

Faculty of MedicineDepartment of Infectious Disease

Honorary Clinical Senior Lecturer
 
 
 
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Contact

 

+44 (0)20 3313 2733p.elkington Website

 
 
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Location

 

8N23Commonwealth BuildingHammersmith Campus

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Summary

 

Summary

My research interest is how tuberculosis causes damage to patients' lungs.  Tuberculosis continues to kill over 2 million people a year, primarily in the developing world, and lung disease not only causes spread from person to person but also causes most mortality and morbidity. 

Within the tuberculosis research group, we integrate analysis of clinical samples with basic scientific approaches to understand the mechanisms of disease.  My research focuses on how enzymes called matrix metalloproteinases drive lung cavitation.  The ultimate aim is to identify new therapeutic targets to improve tuberculosis treatment, which has remained unchanged for the last thirty years.

The extracellular matrix of the lung consists of collagen and elastin fibres, which are highly resistant to breakdown.  Only matrix metalloproteinases (MMPs) can degrade fibrils at neutral pH.   We have shown that tuberculosis specifically up-regulates a collagenase, MMP-1.  The next important question is to determine whether inhibiting this enzyme can reduce deaths from tuberculosis and allow new short course treatments.  

 

  Extensive lung destruction caused by tuberculosis

Extensive lung destruction caused by tuberculosis

Publications

Journals

Elkington P, Lerm M, Kapoor N, et al., 2019, In Vitro Granuloma Models of Tuberculosis: Potential and Challenges, Journal of Infectious Diseases, Vol:219, ISSN:0022-1899, Pages:1858-1866

Barton E, Gao Y, Ball D, et al., 2019, Calcineurin Inhibitors and Variation in the Performance of Interferon-gamma Release Assays Used to Detect Tuberculosis Infection, Annals of the American Thoracic Society, Vol:16, ISSN:1546-3222, Pages:771-775

Rohlwink UK, Walker NF, Ordonez AA, et al., 2019, Matrix metalloproteinases in pulmonary and central nervous system tuberculosis-a review, International Journal of Molecular Sciences, Vol:20, ISSN:1422-0067

Ordonez AA, Pokkali S, Sanchez-Bautista J, et al., 2019, Matrix Metalloproteinase Inhibition in a Murine Model of Cavitary Tuberculosis Paradoxically Worsens Pathology, Journal of Infectious Diseases, Vol:219, ISSN:0022-1899, Pages:633-636

Elkington PT, Bateman AC, Thomas GJ, et al., 2018, Implications of Tuberculosis Reactivation after Immune Checkpoint Inhibition, American Journal of Respiratory and Critical Care Medicine, Vol:198, ISSN:1073-449X, Pages:1451-1453

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