Imperial College London

ProfessorPaulElliott

Faculty of MedicineSchool of Public Health

Chair in Epidemiology and Public Health Medicine
 
 
 
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Contact

 

+44 (0)20 7594 3328p.elliott Website

 
 
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Assistant

 

Miss Jennifer Wells +44 (0)20 7594 3328

 
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Location

 

154Norfolk PlaceSt Mary's Campus

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Summary

 

Publications

Citation

BibTex format

@article{Alves:2019:10.1126/sciadv.aaw3095,
author = {Alves, AC and De, Silva NMG and Karhunen, V and Sovio, U and Das, S and Rob, Taal H and Warrington, NM and Lewin, AM and Kaakinen, M and Cousminer, DL and Thiering, E and Timpson, NJ and Bond, TA and Lowry, E and Brown, CD and Estivill, X and Lindi, V and Bradfield, JP and Geller, F and Speed, D and Coin, LJM and Loh, M and Barton, SJ and Beilin, LJ and Bisgaard, H and Bønnelykke, K and Alili, R and Hatoum, IJ and Schramm, K and Cartwright, R and Charles, MA and Salerno, V and Clément, K and Claringbould, AAJ and Van, Duijn CM and Moltchanova, E and Eriksson, JG and Elks, C and Feenstra, B and Flexeder, C and Franks, S and Frayling, TM and Freathy, RM and Elliott, P and Widén, E and Hakonarson, H and Hattersley, AT and Rodriguez, A and Banterle, M and Heinrich, J and Heude, B and Holloway, JW and Hofman, A and Hyppönen, E and Inskip, H and Kaplan, LM and Hedman, AK and Läärä, E and Prokisch, H and Grallert, H and Lakka, TA and Lawlor, DA and Melbye, M and Ahluwalia, TS and Marinelli, M},
doi = {10.1126/sciadv.aaw3095},
journal = {Science Advances},
title = {GWAS on longitudinal growth traits reveals different genetic factors influencing infant, child, and adult BMI},
url = {http://dx.doi.org/10.1126/sciadv.aaw3095},
volume = {5},
year = {2019}
}

RIS format (EndNote, RefMan)

TY  - JOUR
AB - Early childhood growth patterns are associated with adult health, yet the genetic factors and the developmental stages involved are not fully understood. Here we combine genome-wide association studies with modelling of longitudinal growth traits to study the genetics of infant and child growth, followed by functional, pathway, genetic correlation, risk score and co-localization analyses to determine how developmental timings, molecular pathways and genetic determinants of these traits overlap with those of adult health. We found a robust overlap between the genetics of child and adult BMI, with variants associated with adult BMI acting as early as 4-6 years old. However, we demonstrated a completely distinct genetic makeup for peak BMI during infancy, influenced by variation at the LEPR/LEPROT locus. These findings suggest that different genetic factors control infant and child BMI. In light of the obesity epidemic, these findings are important to inform the timing and targets of prevention strategies.
AU - Alves,AC
AU - De,Silva NMG
AU - Karhunen,V
AU - Sovio,U
AU - Das,S
AU - Rob,Taal H
AU - Warrington,NM
AU - Lewin,AM
AU - Kaakinen,M
AU - Cousminer,DL
AU - Thiering,E
AU - Timpson,NJ
AU - Bond,TA
AU - Lowry,E
AU - Brown,CD
AU - Estivill,X
AU - Lindi,V
AU - Bradfield,JP
AU - Geller,F
AU - Speed,D
AU - Coin,LJM
AU - Loh,M
AU - Barton,SJ
AU - Beilin,LJ
AU - Bisgaard,H
AU - Bønnelykke,K
AU - Alili,R
AU - Hatoum,IJ
AU - Schramm,K
AU - Cartwright,R
AU - Charles,MA
AU - Salerno,V
AU - Clément,K
AU - Claringbould,AAJ
AU - Van,Duijn CM
AU - Moltchanova,E
AU - Eriksson,JG
AU - Elks,C
AU - Feenstra,B
AU - Flexeder,C
AU - Franks,S
AU - Frayling,TM
AU - Freathy,RM
AU - Elliott,P
AU - Widén,E
AU - Hakonarson,H
AU - Hattersley,AT
AU - Rodriguez,A
AU - Banterle,M
AU - Heinrich,J
AU - Heude,B
AU - Holloway,JW
AU - Hofman,A
AU - Hyppönen,E
AU - Inskip,H
AU - Kaplan,LM
AU - Hedman,AK
AU - Läärä,E
AU - Prokisch,H
AU - Grallert,H
AU - Lakka,TA
AU - Lawlor,DA
AU - Melbye,M
AU - Ahluwalia,TS
AU - Marinelli,M
AU - Millwood,IY
AU - Palmer,LJ
AU - Pennell,CE
AU - Perry,JR
AU - Ring,SM
AU - Savolainen,MJ
AU - Rivadeneira,F
AU - Standl,M
AU - Sunyer,J
AU - Tiesler,CMT
AU - Uitterlinden,AG
AU - Schierding,W
AU - Sullivan,OM
AU - Prokopenko,I
AU - Herzig,KH
AU - Smith,GD
AU - O'Reilly,P
AU - Felix,JF
AU - Buxton,JL
AU - Blakemore,AIF
AU - Ong,KK
AU - Jaddoe,VWV
AU - Grant,SFA
AU - Sebert,S
AU - McCarthy,MI
AU - Järvelin,MR
DO - 10.1126/sciadv.aaw3095
PY - 2019///
SN - 2375-2548
TI - GWAS on longitudinal growth traits reveals different genetic factors influencing infant, child, and adult BMI
T2 - Science Advances
UR - http://dx.doi.org/10.1126/sciadv.aaw3095
UR - http://hdl.handle.net/10044/1/71531
VL - 5
ER -