Imperial College London

ProfessorPaulElliott

Faculty of MedicineSchool of Public Health

Chair in Epidemiology and Public Health Medicine
 
 
 
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Contact

 

+44 (0)20 7594 3328p.elliott Website

 
 
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Assistant

 

Miss Jennifer Wells +44 (0)20 7594 3328

 
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Location

 

154Norfolk PlaceSt Mary's Campus

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Summary

 

Publications

Citation

BibTex format

@article{Yan:2019:10.12688/wellcomeopenres.15470.1,
author = {Yan, L and Carter, E and Fu, Y and Guo, D and Huang, P and Xie, G and Xie, W and Zhu, Y and Kelly, F and Elliott, P and Zhao, L and Yang, X and Ezzati, M and Wu, Y and Baumgartner, J and Chan, Q},
doi = {10.12688/wellcomeopenres.15470.1},
journal = {Wellcome Open Research},
pages = {154--154},
title = {Study protocol: The INTERMAP China Prospective (ICP) study},
url = {http://dx.doi.org/10.12688/wellcomeopenres.15470.1},
volume = {4},
year = {2019}
}

RIS format (EndNote, RefMan)

TY  - JOUR
AB - <ns5:p><ns5:bold>Background:</ns5:bold> Unfavourable blood pressure (BP) level is an established risk factor for cardiovascular diseases (CVD), while the exact underlying reasons for unfavourable BP are poorly understood.  The INTERMAP China Prospective (ICP) Study is a prospective cohort to investigate the relationship of environmental and nutritional risk factors with key indicators of vascular function including BP, arterial stiffness, and carotid-intima media thickness.</ns5:p><ns5:p> <ns5:bold>Methods:</ns5:bold> A total of 839 Chinese participants aged 40-59 years from three diverse regions of China were enrolled in INTERMAP in 1997/98; data collection included repeated BP measurements, 24-hour urine specimens, and 24-hour dietary recalls.  In 2015/16, 574 of these 839 persons were re-enrolled along with 208 new participants aged 40-59 years that were randomly selected from the same study villages.  Participant’s environmental and dietary exposures and health outcomes were assessed in this open cohort study, including BP, 24-hour dietary recalls, personal exposures to air pollution, grip strength, arterial stiffness, carotid-media thickness and plaques, cognitive function, and sleep patterns.  Serum and plasma specimens were collected with 24-hour urine specimens.</ns5:p><ns5:p> <ns5:bold>Discussion:</ns5:bold>  Winter and summer assessments of a comprehensive set of vascular indicators and their environmental and nutritional risk factors were conducted with high precision.  We will leverage advances in exposome research to identify biomarkers of exposure to environmental and nutritional risk factors and improve our understanding of the mechanisms and pathways of their hazardous cardiovascular effects.  The ICP Study is observational by design, thus subject to several biases including selection bias (e.g., loss to follow-up), information bias (e.g., measu
AU - Yan,L
AU - Carter,E
AU - Fu,Y
AU - Guo,D
AU - Huang,P
AU - Xie,G
AU - Xie,W
AU - Zhu,Y
AU - Kelly,F
AU - Elliott,P
AU - Zhao,L
AU - Yang,X
AU - Ezzati,M
AU - Wu,Y
AU - Baumgartner,J
AU - Chan,Q
DO - 10.12688/wellcomeopenres.15470.1
EP - 154
PY - 2019///
SP - 154
TI - Study protocol: The INTERMAP China Prospective (ICP) study
T2 - Wellcome Open Research
UR - http://dx.doi.org/10.12688/wellcomeopenres.15470.1
VL - 4
ER -